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A8MYE6

- A8MYE6_HUMAN

UniProt

A8MYE6 - A8MYE6_HUMAN

Protein

Integrin beta

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cell-matrix adhesion Source: InterPro
    2. integrin-mediated signaling pathway Source: UniProtKB-KW
    3. multicellular organismal development Source: InterPro

    Keywords - Molecular functioni

    IntegrinUniRule annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotation

    Enzyme and pathway databases

    SignaLinkiA8MYE6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin betaUniRule annotation
    Gene namesi
    Name:ITGB2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:6155. ITGB2.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiA8MYE6.

    Expressioni

    Gene expression databases

    ArrayExpressiA8MYE6.
    BgeeiA8MYE6.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MYE6.
    SMRiA8MYE6. Positions 23-639, 641-706.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin beta chain family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252936.
    HOVERGENiHBG006190.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR015812. Integrin_bsu.
    IPR015439. Integrin_bsu-2.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF15. PTHR10082:SF15. 1 hit.
    PfamiPF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002512. Integrin_B. 1 hit.
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MYE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN    50
    FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP 100
    QKVTLYLRPG FGSFVDKTVL PFVNTHPDKL RNPCPNKEKE CQPPFAFRHV 150
    LKLTNNSNQF QTEVGKQLIS GNLDAPEGGL DAMMQVAACP EEIGWRNVTR 200
    LLVFATDDGF HFAGDGKLGA ILTPNDGRCH LEDNLYKRSN EFDYPSVGQL 250
    AHKLAENNIQ PIFAVTSRMV KTYEKLTEII PKSAVGELSE DSSNVVQLIK 300
    NAYNKLSSRV FLDHNALPDT LKVTYDSFCS NGVTHRNQPR GDCDGVQINV 350
    PITFQVKVTA TECIQEQSFV IRALGFTDIV TVQVLPQCEC RCRDQSRDRS 400
    LCHGKGFLEC GICRCDTGYI GKNCECQTQG RSSQELEGSC RKDNNSIICS 450
    GLGDCVCGQC LCHTSDVPGK LIYGQYCECD TINCERYNGQ VCGGPGRGLC 500
    FCGKCRCHPG FEGSACQCER TTEGCLNPRR VECSGRGRCR CNVCECHSGY 550
    QLPLCQECPG CPSPCGKYIS CAECLKFEKG PFGKNCSAAC PGLQLSNNPV 600
    KGRTCKERDS EGCWVAYTLE QQDGMDRYLI YVDESRECVA GPNIAAIVGG 650
    TVAGIVLIGI LLLVIWKALI HLSDLREYRR FEKEKLKSQW NNDNPLFKSA 700
    TTTVMNPKFA ES 712
    Length:712
    Mass (Da):78,345
    Last modified:December 4, 2007 - v1
    Checksum:i7792B69E2571C676
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL773603 Genomic DNA. No translation available.
    AL844907 Genomic DNA. No translation available.
    AL844908 Genomic DNA. No translation available.
    KC877928 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000397854; ENSP00000380952; ENSG00000160255.
    UCSCiuc010gpw.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL773603 Genomic DNA. No translation available.
    AL844907 Genomic DNA. No translation available.
    AL844908 Genomic DNA. No translation available.
    KC877928 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A8MYE6.
    SMRi A8MYE6. Positions 23-639, 641-706.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A8MYE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397854 ; ENSP00000380952 ; ENSG00000160255 .
    UCSCi uc010gpw.2. human.

    Organism-specific databases

    HGNCi HGNC:6155. ITGB2.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000252936.
    HOVERGENi HBG006190.

    Enzyme and pathway databases

    SignaLinki A8MYE6.

    Miscellaneous databases

    ChiTaRSi ITGB2. human.
    NextBioi 35465048.

    Gene expression databases

    ArrayExpressi A8MYE6.
    Bgeei A8MYE6.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR015812. Integrin_bsu.
    IPR015439. Integrin_bsu-2.
    IPR014836. Integrin_bsu_cyt_dom.
    IPR002369. Integrin_bsu_N.
    IPR012896. Integrin_bsu_tail.
    IPR016201. Plexin-like_fold.
    IPR002035. VWF_A.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF15. PTHR10082:SF15. 1 hit.
    Pfami PF08725. Integrin_b_cyt. 1 hit.
    PF07965. Integrin_B_tail. 1 hit.
    PF00362. Integrin_beta. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002512. Integrin_B. 1 hit.
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    SSF53300. SSF53300. 1 hit.
    SSF69687. SSF69687. 1 hit.
    PROSITEi PS00243. INTEGRIN_BETA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 21."
      Chromosome 21 mapping and sequencing consortium
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA8MYE6_HUMAN
    AccessioniPrimary (citable) accession number: A8MYE6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3