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A8MYE6

- A8MYE6_HUMAN

UniProt

A8MYE6 - A8MYE6_HUMAN

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Protein
Integrin beta
Gene
ITGB2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell-matrix adhesion Source: InterPro
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
  3. multicellular organismal development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotation

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiA8MYE6.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:6155. ITGB2.

Subcellular locationi

GO - Cellular componenti

  1. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiA8MYE6.

Expressioni

Gene expression databases

ArrayExpressiA8MYE6.
BgeeiA8MYE6.

Structurei

3D structure databases

ProteinModelPortaliA8MYE6.
SMRiA8MYE6. Positions 23-639, 641-706.

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOGENOMiHOG000252936.
HOVERGENiHBG006190.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 2 hits.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MYE6-1 [UniParc]FASTAAdd to Basket

« Hide

MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN    50
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP 100
QKVTLYLRPG FGSFVDKTVL PFVNTHPDKL RNPCPNKEKE CQPPFAFRHV 150
LKLTNNSNQF QTEVGKQLIS GNLDAPEGGL DAMMQVAACP EEIGWRNVTR 200
LLVFATDDGF HFAGDGKLGA ILTPNDGRCH LEDNLYKRSN EFDYPSVGQL 250
AHKLAENNIQ PIFAVTSRMV KTYEKLTEII PKSAVGELSE DSSNVVQLIK 300
NAYNKLSSRV FLDHNALPDT LKVTYDSFCS NGVTHRNQPR GDCDGVQINV 350
PITFQVKVTA TECIQEQSFV IRALGFTDIV TVQVLPQCEC RCRDQSRDRS 400
LCHGKGFLEC GICRCDTGYI GKNCECQTQG RSSQELEGSC RKDNNSIICS 450
GLGDCVCGQC LCHTSDVPGK LIYGQYCECD TINCERYNGQ VCGGPGRGLC 500
FCGKCRCHPG FEGSACQCER TTEGCLNPRR VECSGRGRCR CNVCECHSGY 550
QLPLCQECPG CPSPCGKYIS CAECLKFEKG PFGKNCSAAC PGLQLSNNPV 600
KGRTCKERDS EGCWVAYTLE QQDGMDRYLI YVDESRECVA GPNIAAIVGG 650
TVAGIVLIGI LLLVIWKALI HLSDLREYRR FEKEKLKSQW NNDNPLFKSA 700
TTTVMNPKFA ES 712
Length:712
Mass (Da):78,345
Last modified:December 4, 2007 - v1
Checksum:i7792B69E2571C676
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000397854; ENSP00000380952; ENSG00000160255.
UCSCiuc010gpw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A8MYE6.
SMRi A8MYE6. Positions 23-639, 641-706.
ModBasei Search...

Proteomic databases

PRIDEi A8MYE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397854 ; ENSP00000380952 ; ENSG00000160255 .
UCSCi uc010gpw.2. human.

Organism-specific databases

HGNCi HGNC:6155. ITGB2.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000252936.
HOVERGENi HBG006190.

Enzyme and pathway databases

SignaLinki A8MYE6.

Miscellaneous databases

ChiTaRSi ITGB2. human.
GenomeRNAii 3689.
NextBioi 35465048.

Gene expression databases

ArrayExpressi A8MYE6.
Bgeei A8MYE6.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
Pfami PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 2 hits.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA8MYE6_HUMAN
AccessioniPrimary (citable) accession number: A8MYE6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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