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A8MXZ3

- KRA91_HUMAN

UniProt

A8MXZ3 - KRA91_HUMAN

Protein

Keratin-associated protein 9-1

Gene

KRTAP9-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 9-1
    Gene namesi
    Name:KRTAP9-1
    Synonyms:KAP9.1, KRTAP9.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18912. KRTAP9-1.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939475.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Keratin-associated protein 9-1PRO_0000332261Add
    BLAST

    Proteomic databases

    PaxDbiA8MXZ3.
    PRIDEiA8MXZ3.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MXZ3.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381488.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MXZ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati8 – 1251
    Repeati13 – 1752
    Repeati18 – 2253
    Repeati37 – 4154
    Repeati42 – 4655
    Repeati51 – 5556
    Repeati56 – 6057
    Repeati61 – 6558
    Repeati66 – 7059
    Repeati75 – 79510
    Repeati80 – 84511
    Repeati85 – 89512
    Repeati90 – 94513
    Repeati95 – 99514
    Repeati105 – 109515
    Repeati133 – 137516
    Repeati138 – 142517
    Repeati143 – 147518
    Repeati153 – 157519
    Repeati162 – 166520
    Repeati167 – 171521
    Repeati176 – 180522
    Repeati185 – 189523
    Repeati190 – 194524
    Repeati214 – 218525
    Repeati219 – 223526
    Repeati229 – 233527
    Repeati234 – 238528
    Repeati239 – 243529
    Repeati244 – 248530

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 24824130 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 9 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG320652.
    HOGENOMiHOG000234030.
    InParanoidiA8MXZ3.
    OMAiTVSVCQP.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF13885. Keratin_B2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MXZ3-1 [UniParc]FASTAAdd to Basket

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    MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP    50
    CCHPTCCQNT CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS 100
    CGSSCCQPIC GSSCCQPCCH PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ 150
    PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS CVTRCCSTPC CQPTCGGSSC 200
    CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC VSSCCQPSCC 250
    Length:250
    Mass (Da):26,333
    Last modified:December 4, 2007 - v1
    Checksum:i38CEDE3EF8F2ACF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSiCCDS56029.1.
    RefSeqiNP_001177389.1. NM_001190460.1.
    UniGeneiHs.727478.

    Genome annotation databases

    EnsembliENST00000398470; ENSP00000381488; ENSG00000240542.
    GeneIDi728318.
    KEGGihsa:728318.
    UCSCiuc021txf.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSi CCDS56029.1.
    RefSeqi NP_001177389.1. NM_001190460.1.
    UniGenei Hs.727478.

    3D structure databases

    ProteinModelPortali A8MXZ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381488.

    Proteomic databases

    PaxDbi A8MXZ3.
    PRIDEi A8MXZ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398470 ; ENSP00000381488 ; ENSG00000240542 .
    GeneIDi 728318.
    KEGGi hsa:728318.
    UCSCi uc021txf.1. human.

    Organism-specific databases

    CTDi 728318.
    GeneCardsi GC17P039344.
    HGNCi HGNC:18912. KRTAP9-1.
    neXtProti NX_A8MXZ3.
    PharmGKBi PA134939475.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320652.
    HOGENOMi HOG000234030.
    InParanoidi A8MXZ3.
    OMAi TVSVCQP.
    TreeFami TF351356.

    Miscellaneous databases

    NextBioi 126790.
    PROi A8MXZ3.

    Gene expression databases

    Genevestigatori A8MXZ3.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF13885. Keratin_B2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKRA91_HUMAN
    AccessioniPrimary (citable) accession number: A8MXZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3