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A8MXZ3 (KRA91_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 9-1
Gene names
Name:KRTAP9-1
Synonyms:KAP9.1, KRTAP9.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 9 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Keratin-associated protein 9-1
PRO_0000332261

Regions

Repeat8 – 1251
Repeat13 – 1752
Repeat18 – 2253
Repeat37 – 4154
Repeat42 – 4655
Repeat51 – 5556
Repeat56 – 6057
Repeat61 – 6558
Repeat66 – 7059
Repeat75 – 79510
Repeat80 – 84511
Repeat85 – 89512
Repeat90 – 94513
Repeat95 – 99514
Repeat105 – 109515
Repeat133 – 137516
Repeat138 – 142517
Repeat143 – 147518
Repeat153 – 157519
Repeat162 – 166520
Repeat167 – 171521
Repeat176 – 180522
Repeat185 – 189523
Repeat190 – 194524
Repeat214 – 218525
Repeat219 – 223526
Repeat229 – 233527
Repeat234 – 238528
Repeat239 – 243529
Repeat244 – 248530
Region8 – 24824130 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]

Sequences

Sequence LengthMass (Da)Tools
A8MXZ3 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 38CEDE3EF8F2ACF2

FASTA25026,333
        10         20         30         40         50         60 
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP CCHPTCCQNT 

        70         80         90        100        110        120 
CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS CGSSCCQPIC GSSCCQPCCH 

       130        140        150        160        170        180 
PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS 

       190        200        210        220        230        240 
CVTRCCSTPC CQPTCGGSSC CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC 

       250 
VSSCCQPSCC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006070 Genomic DNA. No translation available.
RefSeqNP_001177389.1. NM_001190460.1.
UniGeneHs.727478.

3D structure databases

ProteinModelPortalA8MXZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000381488.

Proteomic databases

PaxDbA8MXZ3.
PRIDEA8MXZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398470; ENSP00000381488; ENSG00000240542.
GeneID728318.
KEGGhsa:728318.
UCSCuc021txf.1. human.

Organism-specific databases

CTD728318.
GeneCardsGC17P039344.
HGNCHGNC:18912. KRTAP9-1.
neXtProtNX_A8MXZ3.
PharmGKBPA134939475.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320652.
HOGENOMHOG000234030.
InParanoidA8MXZ3.
OMAICGSSCC.
TreeFamTF351356.

Gene expression databases

GenevestigatorA8MXZ3.

Family and domain databases

InterProIPR002494. Keratin-assoc.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
ProtoNetSearch...

Other

NextBio126790.
PROA8MXZ3.

Entry information

Entry nameKRA91_HUMAN
AccessionPrimary (citable) accession number: A8MXZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM