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Protein

Keratin-associated protein 9-1

Gene

KRTAP9-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:G66-30699-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-1
Gene namesi
Name:KRTAP9-1
Synonyms:KAP9.1, KRTAP9.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18912. KRTAP9-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000240542.
PharmGKBiPA134939475.

Polymorphism and mutation databases

BioMutaiKRTAP9-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322611 – 250Keratin-associated protein 9-1Add BLAST250

Proteomic databases

PaxDbiA8MXZ3.
PRIDEiA8MXZ3.

PTM databases

iPTMnetiA8MXZ3.
PhosphoSitePlusiA8MXZ3.

Expressioni

Gene expression databases

ExpressionAtlasiA8MXZ3. baseline.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

BioGridi608746. 1 interactor.
STRINGi9606.ENSP00000381488.

Structurei

3D structure databases

ProteinModelPortaliA8MXZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1215
Repeati13 – 1725
Repeati18 – 2235
Repeati37 – 4145
Repeati42 – 4655
Repeati51 – 5565
Repeati56 – 6075
Repeati61 – 6585
Repeati66 – 7095
Repeati75 – 79105
Repeati80 – 84115
Repeati85 – 89125
Repeati90 – 94135
Repeati95 – 99145
Repeati105 – 109155
Repeati133 – 137165
Repeati138 – 142175
Repeati143 – 147185
Repeati153 – 157195
Repeati162 – 166205
Repeati167 – 171215
Repeati176 – 180225
Repeati185 – 189235
Repeati190 – 194245
Repeati214 – 218255
Repeati219 – 223265
Repeati229 – 233275
Repeati234 – 238285
Repeati239 – 243295
Repeati244 – 248305

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 24830 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]Add BLAST241

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC5E. Eukaryota.
ENOG4111612. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiA8MXZ3.
OMAiICGSSCC.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 2 hits.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MXZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP
60 70 80 90 100
CCHPTCCQNT CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS
110 120 130 140 150
CGSSCCQPIC GSSCCQPCCH PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ
160 170 180 190 200
PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS CVTRCCSTPC CQPTCGGSSC
210 220 230 240 250
CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC VSSCCQPSCC
Length:250
Mass (Da):26,333
Last modified:December 4, 2007 - v1
Checksum:i38CEDE3EF8F2ACF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS56029.1.
RefSeqiNP_001177389.1. NM_001190460.1.
UniGeneiHs.727478.

Genome annotation databases

EnsembliENST00000398470; ENSP00000381488; ENSG00000240542.
GeneIDi728318.
KEGGihsa:728318.
UCSCiuc021txf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS56029.1.
RefSeqiNP_001177389.1. NM_001190460.1.
UniGeneiHs.727478.

3D structure databases

ProteinModelPortaliA8MXZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608746. 1 interactor.
STRINGi9606.ENSP00000381488.

PTM databases

iPTMnetiA8MXZ3.
PhosphoSitePlusiA8MXZ3.

Polymorphism and mutation databases

BioMutaiKRTAP9-1.

Proteomic databases

PaxDbiA8MXZ3.
PRIDEiA8MXZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398470; ENSP00000381488; ENSG00000240542.
GeneIDi728318.
KEGGihsa:728318.
UCSCiuc021txf.1. human.

Organism-specific databases

CTDi728318.
GeneCardsiKRTAP9-1.
HGNCiHGNC:18912. KRTAP9-1.
neXtProtiNX_A8MXZ3.
OpenTargetsiENSG00000240542.
PharmGKBiPA134939475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC5E. Eukaryota.
ENOG4111612. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiA8MXZ3.
OMAiICGSSCC.
TreeFamiTF351356.

Enzyme and pathway databases

BioCyciZFISH:G66-30699-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii728318.
PROiA8MXZ3.

Gene expression databases

ExpressionAtlasiA8MXZ3. baseline.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 2 hits.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA91_HUMAN
AccessioniPrimary (citable) accession number: A8MXZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.