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A8MXZ3

- KRA91_HUMAN

UniProt

A8MXZ3 - KRA91_HUMAN

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Protein

Keratin-associated protein 9-1

Gene

KRTAP9-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-1
Gene namesi
Name:KRTAP9-1
Synonyms:KAP9.1, KRTAP9.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18912. KRTAP9-1.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Keratin-associated protein 9-1PRO_0000332261Add
BLAST

Proteomic databases

PaxDbiA8MXZ3.
PRIDEiA8MXZ3.

Expressioni

Gene expression databases

GenevestigatoriA8MXZ3.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000381488.

Structurei

3D structure databases

ProteinModelPortaliA8MXZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 1251
Repeati13 – 1752
Repeati18 – 2253
Repeati37 – 4154
Repeati42 – 4655
Repeati51 – 5556
Repeati56 – 6057
Repeati61 – 6558
Repeati66 – 7059
Repeati75 – 79510
Repeati80 – 84511
Repeati85 – 89512
Repeati90 – 94513
Repeati95 – 99514
Repeati105 – 109515
Repeati133 – 137516
Repeati138 – 142517
Repeati143 – 147518
Repeati153 – 157519
Repeati162 – 166520
Repeati167 – 171521
Repeati176 – 180522
Repeati185 – 189523
Repeati190 – 194524
Repeati214 – 218525
Repeati219 – 223526
Repeati229 – 233527
Repeati234 – 238528
Repeati239 – 243529
Repeati244 – 248530

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 24824130 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG320652.
GeneTreeiENSGT00730000110544.
HOGENOMiHOG000234030.
InParanoidiA8MXZ3.
OMAiTVSVCQP.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MXZ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP
60 70 80 90 100
CCHPTCCQNT CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS
110 120 130 140 150
CGSSCCQPIC GSSCCQPCCH PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ
160 170 180 190 200
PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS CVTRCCSTPC CQPTCGGSSC
210 220 230 240 250
CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC VSSCCQPSCC
Length:250
Mass (Da):26,333
Last modified:December 4, 2007 - v1
Checksum:i38CEDE3EF8F2ACF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS56029.1.
RefSeqiNP_001177389.1. NM_001190460.1.
UniGeneiHs.727478.

Genome annotation databases

EnsembliENST00000398470; ENSP00000381488; ENSG00000240542.
GeneIDi728318.
KEGGihsa:728318.
UCSCiuc021txf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSi CCDS56029.1.
RefSeqi NP_001177389.1. NM_001190460.1.
UniGenei Hs.727478.

3D structure databases

ProteinModelPortali A8MXZ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381488.

Proteomic databases

PaxDbi A8MXZ3.
PRIDEi A8MXZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398470 ; ENSP00000381488 ; ENSG00000240542 .
GeneIDi 728318.
KEGGi hsa:728318.
UCSCi uc021txf.1. human.

Organism-specific databases

CTDi 728318.
GeneCardsi GC17P039344.
HGNCi HGNC:18912. KRTAP9-1.
neXtProti NX_A8MXZ3.
PharmGKBi PA134939475.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320652.
GeneTreei ENSGT00730000110544.
HOGENOMi HOG000234030.
InParanoidi A8MXZ3.
OMAi TVSVCQP.
TreeFami TF351356.

Miscellaneous databases

GenomeRNAii 728318.
NextBioi 126790.
PROi A8MXZ3.

Gene expression databases

Genevestigatori A8MXZ3.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
Pfami PF13885. Keratin_B2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKRA91_HUMAN
AccessioniPrimary (citable) accession number: A8MXZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3