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Protein

Zinc finger protein 99

Gene

ZNF99

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri789 – 81123C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri817 – 83923C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 99
Gene namesi
Name:ZNF99
Synonyms:C19orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13175. ZNF99.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Zinc finger protein 99PRO_0000429127Add
BLAST

Proteomic databases

PRIDEiA8MXY4.

PTM databases

iPTMnetiA8MXY4.
PhosphoSiteiA8MXY4.

Expressioni

Gene expression databases

CleanExiHS_ZNF99.
ExpressionAtlasiA8MXY4. baseline and differential.
GenevisibleiA8MXY4. HS.

Structurei

3D structure databases

ProteinModelPortaliA8MXY4.
SMRiA8MXY4. Positions 138-846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 24 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 22PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri789 – 81123C2H2-type 23PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri817 – 83923C2H2-type 24PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MXY4.
KOiK09228.
OMAiWSSKLME.
OrthoDBiEOG7KSX7Q.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 24 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MXY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLTFWDVT IEFALEEWQC LDMAQQNLYR NVMLENYRNL VFLGIAVSKL
60 70 80 90 100
DLITCLKQGK EPWNMKRHEM VTKPPVISSH FTQDFWPDQS IKDSFQEIIL
110 120 130 140 150
RTYARCGHKN LRLRKDCESV NEGKMHEEAY NKLNQCWTTT QGKIFQCNKY
160 170 180 190 200
VKVFHKYSNS NRYKIRHTKK KTFKCMKCSK SFFMLSHLIQ HKRIHTRENI
210 220 230 240 250
YKCEERGKAF KWFSTLIKHK IIHTEDKPYK YKKCGKAFNI SSMFTKCKII
260 270 280 290 300
HTGKKPCKCE ECGKVFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL
310 320 330 340 350
TRHKAIHTGE KPYKCEECGK AFNHFSALRK HQIIHTGKKP YKCEECGKAF
360 370 380 390 400
SQSSTLRKHE IIHTEEKPYK YEECGKAFSN LSALRKHEII HTGQKPYKCE
410 420 430 440 450
ECGKAFKWSS KLTVHKVIHT AEKPCKCEEC GKAFKRFSAL RKHKIIHTGK
460 470 480 490 500
QPYKCEECSK AFSNFSALRK HEIIHTGEKP YKCEECGKAF KWSSKLTVHK
510 520 530 540 550
VIHMEEKPCK CEECGKAFKH FSALRKHKII HTGKKPYKCE ECGKAFNNSS
560 570 580 590 600
TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL TRHKAIHTGE KPYKCEECGK
610 620 630 640 650
AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE IIHTGEKPYK
660 670 680 690 700
CEECGKAFKW SSHLTRHKVI HTEEKPYKCE ECGKAFNHFS ALRKHKIIHT
710 720 730 740 750
GKKPYKCEEC GKAFSQSSTL RKHEIIHTGE KPYKCEECGK AFKWSSKLTV
760 770 780 790 800
HKVIHTAEKP CKCEECGKAF KHFSALRKHK IIHTGKKPYK CEECGKAFNN
810 820 830 840 850
SSTLRKHEII HTGEKSYKCE ECGKAFQWSS KLTLHKVIHM ERNPANVKNV
860
AKLLNISQPL ENMR
Length:864
Mass (Da):100,791
Last modified:May 14, 2014 - v3
Checksum:iDF66A625F51E5149
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71W → R.
Corresponds to variant rs34726149 [ dbSNP | Ensembl ].
VAR_061935
Natural varianti129 – 1291A → G.
Corresponds to variant rs7255780 [ dbSNP | Ensembl ].
VAR_044501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008626 Genomic DNA. No translation available.
CCDSiCCDS59369.1.
RefSeqiNP_001073878.2. NM_001080409.2.
UniGeneiHs.568380.
Hs.737077.

Genome annotation databases

EnsembliENST00000596209; ENSP00000472969; ENSG00000213973.
GeneIDi7652.
KEGGihsa:7652.
UCSCiuc021urt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008626 Genomic DNA. No translation available.
CCDSiCCDS59369.1.
RefSeqiNP_001073878.2. NM_001080409.2.
UniGeneiHs.568380.
Hs.737077.

3D structure databases

ProteinModelPortaliA8MXY4.
SMRiA8MXY4. Positions 138-846.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA8MXY4.
PhosphoSiteiA8MXY4.

Proteomic databases

PRIDEiA8MXY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000596209; ENSP00000472969; ENSG00000213973.
GeneIDi7652.
KEGGihsa:7652.
UCSCiuc021urt.2. human.

Organism-specific databases

CTDi7652.
GeneCardsiZNF99.
HGNCiHGNC:13175. ZNF99.
MIMi603981. gene.
neXtProtiNX_A8MXY4.
PharmGKBiPA37747.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129700.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MXY4.
KOiK09228.
OMAiWSSKLME.
OrthoDBiEOG7KSX7Q.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7652.
NextBioi21517395.
PROiA8MXY4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ZNF99.
ExpressionAtlasiA8MXY4. baseline and differential.
GenevisibleiA8MXY4. HS.

Family and domain databases

Gene3Di3.30.160.60. 24 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 24 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells."
    Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.C., Martial J.A.
    EMBO J. 12:1363-1374(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-154.

Entry informationi

Entry nameiZNF99_HUMAN
AccessioniPrimary (citable) accession number: A8MXY4
Secondary accession number(s): M0R335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 14, 2014
Last modified: May 11, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.