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Protein

Nucleoside diphosphate-linked moiety X motif 19

Gene

NUDT19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Magnesium or manganeseBy similarity1
Metal bindingi135Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-389887. Beta-oxidation of pristanoyl-CoA.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 19 (EC:3.6.1.-)
Short name:
Nudix motif 19
Gene namesi
Name:NUDT19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32036. NUDT19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi390916.
OpenTargetsiENSG00000213965.
PharmGKBiPA142671239.

Polymorphism and mutation databases

BioMutaiNUDT19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245711 – 375Nucleoside diphosphate-linked moiety X motif 19Add BLAST375

Proteomic databases

EPDiA8MXV4.
MaxQBiA8MXV4.
PaxDbiA8MXV4.
PRIDEiA8MXV4.

PTM databases

iPTMnetiA8MXV4.
PhosphoSitePlusiA8MXV4.

Expressioni

Gene expression databases

BgeeiENSG00000213965.
CleanExiHS_NUDT19.
GenevisibleiA8MXV4. HS.

Interactioni

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi133735. 14 interactors.
IntActiA8MXV4. 1 interactor.
STRINGi9606.ENSP00000380251.

Structurei

3D structure databases

ProteinModelPortaliA8MXV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 263Nudix hydrolasePROSITE-ProRule annotationAdd BLAST249

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi116 – 137Nudix boxAdd BLAST22
Motifi373 – 375Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3904. Eukaryota.
ENOG4111FKM. LUCA.
GeneTreeiENSGT00420000029858.
HOGENOMiHOG000060163.
HOVERGENiHBG017737.
InParanoidiA8MXV4.
KOiK13355.
OMAiCDYNALL.
OrthoDBiEOG091G0B8I.
PhylomeDBiA8MXV4.
TreeFamiTF313185.

Family and domain databases

Gene3Di3.90.79.10. 3 hits.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 3 hits.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MXV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLRPGPS RWRRAASIVL AAGWSRPETA TPPSRPPPAE GFRLLLLQRS
60 70 80 90 100
PHQGFMPGAH VFSGGVLDAA DRSADWLGLF APHHGPPRFG LGPAPFSRTA
110 120 130 140 150
FPSLPDTDDH KTDNTGTLPE DVAFRICAVR EAFEEAGVLL LRPRTSPPGP
160 170 180 190 200
APGPGLALEP PPGLASWRDR VRQDPRHFLR LCAHLDCTPD IWALHNWSAW
210 220 230 240 250
LTPFLRGTTR RFDTAFFLCC LREPPPVYPD LAEVVGYQWS SPSEATESFL
260 270 280 290 300
SKEIWLPPPQ FYEVRRLANF ASLSDLHKFC LGRALEGLER WLPIILLTAD
310 320 330 340 350
GMVHLLPGDE LYLEDSDFLE NLMSTEKKTE EIMKEGKQFH RIVTYHRHLY
360 370
DIHVTVQPKY KHVYPKNSVV RKSHL
Length:375
Mass (Da):42,233
Last modified:December 4, 2007 - v1
Checksum:iD02AE72BE8615DA3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03983143R → Q.Corresponds to variant rs10413282dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008736 Genomic DNA. No translation available.
CCDSiCCDS42543.1.
RefSeqiNP_001099040.1. NM_001105570.1.
UniGeneiHs.203961.

Genome annotation databases

EnsembliENST00000397061; ENSP00000380251; ENSG00000213965.
GeneIDi390916.
KEGGihsa:390916.
UCSCiuc010edf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008736 Genomic DNA. No translation available.
CCDSiCCDS42543.1.
RefSeqiNP_001099040.1. NM_001105570.1.
UniGeneiHs.203961.

3D structure databases

ProteinModelPortaliA8MXV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133735. 14 interactors.
IntActiA8MXV4. 1 interactor.
STRINGi9606.ENSP00000380251.

PTM databases

iPTMnetiA8MXV4.
PhosphoSitePlusiA8MXV4.

Polymorphism and mutation databases

BioMutaiNUDT19.

Proteomic databases

EPDiA8MXV4.
MaxQBiA8MXV4.
PaxDbiA8MXV4.
PRIDEiA8MXV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397061; ENSP00000380251; ENSG00000213965.
GeneIDi390916.
KEGGihsa:390916.
UCSCiuc010edf.3. human.

Organism-specific databases

CTDi390916.
DisGeNETi390916.
GeneCardsiNUDT19.
HGNCiHGNC:32036. NUDT19.
neXtProtiNX_A8MXV4.
OpenTargetsiENSG00000213965.
PharmGKBiPA142671239.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3904. Eukaryota.
ENOG4111FKM. LUCA.
GeneTreeiENSGT00420000029858.
HOGENOMiHOG000060163.
HOVERGENiHBG017737.
InParanoidiA8MXV4.
KOiK13355.
OMAiCDYNALL.
OrthoDBiEOG091G0B8I.
PhylomeDBiA8MXV4.
TreeFamiTF313185.

Enzyme and pathway databases

ReactomeiR-HSA-389887. Beta-oxidation of pristanoyl-CoA.

Miscellaneous databases

GenomeRNAii390916.
PROiA8MXV4.

Gene expression databases

BgeeiENSG00000213965.
CleanExiHS_NUDT19.
GenevisibleiA8MXV4. HS.

Family and domain databases

Gene3Di3.90.79.10. 3 hits.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 3 hits.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUD19_HUMAN
AccessioniPrimary (citable) accession number: A8MXV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.