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A8MXU0 (D108A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-defensin 108A
Alternative name(s):
Defensin, beta 108A
Putative beta-defensin 108B pseudogene 1/2
Gene names
Name:DEFB108P1
Synonyms:DEFB108A
AND
Name:DEFB108P2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length73 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceUncertain

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 7351Putative beta-defensin 108A
PRO_0000341263

Amino acid modifications

Disulfide bond28 ↔ 55 By similarity
Disulfide bond35 ↔ 49 By similarity
Disulfide bond39 ↔ 56 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MXU0 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: ED4C8C652A4C7FDA

FASTA738,390
        10         20         30         40         50         60 
MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL NSRPCCLPLG 

        70 
HQPRIESTTP KKD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC130360 Genomic DNA. No translation available.
AF540980 mRNA. No translation available.
UniGeneHs.583890.

3D structure databases

ProteinModelPortalA8MXU0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000383018.

Proteomic databases

PaxDbA8MXU0.
PRIDEA8MXU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC08M007791.
GC08P007220.
HGNCHGNC:18089. DEFB108P1.
HGNC:30847. DEFB108P2.
neXtProtNX_A8MXU0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87878.
HOGENOMHOG000112137.
HOVERGENHBG081400.
InParanoidA8MXU0.
PhylomeDBA8MXU0.

Gene expression databases

GenevestigatorA8MXU0.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA8MXU0.

Entry information

Entry nameD108A_HUMAN
AccessionPrimary (citable) accession number: A8MXU0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM