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Protein

Putative beta-defensin 108A

Gene

DEFB108P1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

BioCyciZFISH:G66-31766-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-defensin 108A
Alternative name(s):
Defensin, beta 108A
Putative beta-defensin 108B pseudogene 1/2
Gene namesi
Name:DEFB108P1
Synonyms:DEFB108A
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18089. DEFB108P1.
HGNC:30847. DEFB108P2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000034126323 – 73Putative beta-defensin 108AAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiA8MXU0.

Expressioni

Organism-specific databases

HPAiHPA042588.

Structurei

3D structure databases

ProteinModelPortaliA8MXU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000112137.
HOVERGENiHBG081400.
InParanoidiA8MXU0.
PhylomeDBiA8MXU0.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MXU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL
60 70
NSRPCCLPLG HQPRIESTTP KKD
Length:73
Mass (Da):8,390
Last modified:June 10, 2008 - v2
Checksum:iED4C8C652A4C7FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
AF540980 mRNA. No translation available.
UniGeneiHs.583890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
AF540980 mRNA. No translation available.
UniGeneiHs.583890.

3D structure databases

ProteinModelPortaliA8MXU0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA8MXU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiDEFB108P1.
DEFB108P2.
HGNCiHGNC:18089. DEFB108P1.
HGNC:30847. DEFB108P2.
HPAiHPA042588.
neXtProtiNX_A8MXU0.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000112137.
HOVERGENiHBG081400.
InParanoidiA8MXU0.
PhylomeDBiA8MXU0.

Enzyme and pathway databases

BioCyciZFISH:G66-31766-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.

Miscellaneous databases

PROiA8MXU0.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD108A_HUMAN
AccessioniPrimary (citable) accession number: A8MXU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.