A8MXU0 (D108A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative beta-defensin 108A

Alternative name(s):
Defensin, beta 108A
Putative beta-defensin 108B pseudogene 1/2

Gene names

Name:	DEFB108P1
Synonyms:	DEFB108A
AND
Name:	DEFB108P2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 73	51	Putative beta-defensin 108A		PRO_0000341263
Amino acid modifications
	Disulfide bond	28 ↔ 55		By similarity
	Disulfide bond	35 ↔ 49		By similarity
	Disulfide bond	39 ↔ 56		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8MXU0 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: ED4C8C652A4C7FDA	FASTA	73	8,390
	10 20 30 40 50 60 MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL NSRPCCLPLG 70 HQPRIESTTP KKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Duplication and selection in the evolution of primate beta-defensin genes." Semple C.A.M., Rolfe M., Dorin J.R. Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC130360 Genomic DNA. No translation available. AF540980 mRNA. No translation available.
IPI	IPI00853126.
UniGene	Hs.583890.
3D structure databases
ProteinModelPortal	A8MXU0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000383018.
Proteomic databases
PaxDb	A8MXU0.
PRIDE	A8MXU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC08M007791. GC08P007220.
HGNC	HGNC:18089. DEFB108P1. HGNC:30847. DEFB108P2.
neXtProt	NX_A8MXU0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87878.
HOGENOM	HOG000112137.
HOVERGEN	HBG081400.
InParanoid	A8MXU0.
OrthoDB	EOG4TMR3Q.
Gene expression databases
Genevestigator	A8MXU0.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D108A_HUMAN

Accession

Primary (citable) accession number: A8MXU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	April 3, 2013
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.