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Protein

Putative beta-defensin 108A

Gene

DEFB108A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Has antibacterial activity.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-defensin 108A
Alternative name(s):
Defensin, beta 108AImported
Defensin, beta 108CImported
Putative beta-defensin 108B pseudogene 1/2
Gene namesi
Name:DEFB108AImported
Synonyms:DEFB108P1
AND
Name:DEFB108CImported
Synonyms:DEFB108P2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18089 DEFB108A
HGNC:30847 DEFB108C
neXtProtiNX_A8MXU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000034126323 – 73Putative beta-defensin 108AAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiA8MXU0

Expressioni

Organism-specific databases

HPAiHPA042588

Structurei

3D structure databases

ProteinModelPortaliA8MXU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000112137
HOVERGENiHBG081400
InParanoidiA8MXU0
PhylomeDBiA8MXU0

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MXU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL
60 70
NSRPCCLPLG HQPRIESTTP KKD
Length:73
Mass (Da):8,390
Last modified:June 10, 2008 - v2
Checksum:iED4C8C652A4C7FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA No translation available.
AF540980 mRNA No translation available.
UniGeneiHs.583890

Similar proteinsi

Entry informationi

Entry nameiDB108_HUMAN
AccessioniPrimary (citable) accession number: A8MXU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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