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A8MXU0

- D108A_HUMAN

UniProt

A8MXU0 - D108A_HUMAN

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Protein

Putative beta-defensin 108A

Gene

DEFB108P1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-defensin 108A
Alternative name(s):
Defensin, beta 108A
Putative beta-defensin 108B pseudogene 1/2
Gene namesi
Name:DEFB108P1
Synonyms:DEFB108A
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:18089. DEFB108P1.
HGNC:30847. DEFB108P2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 7351Putative beta-defensin 108APRO_0000341263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA8MXU0.
PRIDEiA8MXU0.

Expressioni

Gene expression databases

GenevestigatoriA8MXU0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383018.

Structurei

3D structure databases

ProteinModelPortaliA8MXU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87878.
HOGENOMiHOG000112137.
HOVERGENiHBG081400.
InParanoidiA8MXU0.
PhylomeDBiA8MXU0.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MXU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL
60 70
NSRPCCLPLG HQPRIESTTP KKD
Length:73
Mass (Da):8,390
Last modified:June 10, 2008 - v2
Checksum:iED4C8C652A4C7FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
AF540980 mRNA. No translation available.
UniGeneiHs.583890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
AF540980 mRNA. No translation available.
UniGenei Hs.583890.

3D structure databases

ProteinModelPortali A8MXU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000383018.

Proteomic databases

PaxDbi A8MXU0.
PRIDEi A8MXU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC08M007791.
GC08P007220.
HGNCi HGNC:18089. DEFB108P1.
HGNC:30847. DEFB108P2.
neXtProti NX_A8MXU0.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87878.
HOGENOMi HOG000112137.
HOVERGENi HBG081400.
InParanoidi A8MXU0.
PhylomeDBi A8MXU0.

Miscellaneous databases

PROi A8MXU0.

Gene expression databases

Genevestigatori A8MXU0.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Duplication and selection in the evolution of primate beta-defensin genes."
    Semple C.A.M., Rolfe M., Dorin J.R.
    Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.

Entry informationi

Entry nameiD108A_HUMAN
AccessioniPrimary (citable) accession number: A8MXU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3