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A8MXU0

- D108A_HUMAN

UniProt

A8MXU0 - D108A_HUMAN

Protein

Putative beta-defensin 108A

Gene

DEFB108P1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-defensin 108A
    Alternative name(s):
    Defensin, beta 108A
    Putative beta-defensin 108B pseudogene 1/2
    Gene namesi
    Name:DEFB108P1
    Synonyms:DEFB108A
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18089. DEFB108P1.
    HGNC:30847. DEFB108P2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 7351Putative beta-defensin 108APRO_0000341263Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 55By similarity
    Disulfide bondi35 ↔ 49By similarity
    Disulfide bondi39 ↔ 56By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiA8MXU0.
    PRIDEiA8MXU0.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MXU0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000383018.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MXU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87878.
    HOGENOMiHOG000112137.
    HOVERGENiHBG081400.
    InParanoidiA8MXU0.
    PhylomeDBiA8MXU0.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8MXU0-1 [UniParc]FASTAAdd to Basket

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    MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL   50
    NSRPCCLPLG HQPRIESTTP KKD 73
    Length:73
    Mass (Da):8,390
    Last modified:June 10, 2008 - v2
    Checksum:iED4C8C652A4C7FDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC130360 Genomic DNA. No translation available.
    AF540980 mRNA. No translation available.
    UniGeneiHs.583890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC130360 Genomic DNA. No translation available.
    AF540980 mRNA. No translation available.
    UniGenei Hs.583890.

    3D structure databases

    ProteinModelPortali A8MXU0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000383018.

    Proteomic databases

    PaxDbi A8MXU0.
    PRIDEi A8MXU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC08M007791.
    GC08P007220.
    HGNCi HGNC:18089. DEFB108P1.
    HGNC:30847. DEFB108P2.
    neXtProti NX_A8MXU0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87878.
    HOGENOMi HOG000112137.
    HOVERGENi HBG081400.
    InParanoidi A8MXU0.
    PhylomeDBi A8MXU0.

    Miscellaneous databases

    PROi A8MXU0.

    Gene expression databases

    Genevestigatori A8MXU0.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Duplication and selection in the evolution of primate beta-defensin genes."
      Semple C.A.M., Rolfe M., Dorin J.R.
      Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.

    Entry informationi

    Entry nameiD108A_HUMAN
    AccessioniPrimary (citable) accession number: A8MXU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3