Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen B17

Gene

MAGEB17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B17
Gene namesi
Name:MAGEB17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17418. MAGEB17.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134872991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Melanoma-associated antigen B17PRO_0000332218Add
BLAST

Proteomic databases

PaxDbiA8MXT2.
PRIDEiA8MXT2.

PTM databases

PhosphoSiteiA8MXT2.

Expressioni

Gene expression databases

BgeeiA8MXT2.
GenevestigatoriA8MXT2.

Organism-specific databases

HPAiHPA003756.

Structurei

3D structure databases

ProteinModelPortaliA8MXT2.
SMRiA8MXT2. Positions 101-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 336228MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG266245.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiA8MXT2.
OMAiWECLNAL.
OrthoDBiEOG75F4GM.
PhylomeDBiA8MXT2.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MXT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQASKRR AREKRRQARG EDQCLGGAQA TAAEKEKLPS SSSPACQSPP
60 70 80 90 100
QSFPNAGIPQ ESQRASYPSS PASAVSLTSS DEGAKGQKGE SPNSFHGPSS
110 120 130 140 150
SESTGRDLLN TKTGELVQFL LNKYIRKEPI TREAMLKVIN RKYKQHFPEI
160 170 180 190 200
LRRSTENVEV VFGLYLKEMD PSRQSYVLVG KLDFPNQGSL SDGGGFPLSG
210 220 230 240 250
LLMVLLSTIF MHGNRATEEE MWECLNALGM YKGRKHFIYG EPQELVTKDL
260 270 280 290 300
VREGYLEYQQ VPSSDPPRYE FLWGPRARAE TSKMKVLEFV AKLNDTVAST
310 320 330
YKSRYEEALR EEEEQARARA VARDSARARA SRSFQP
Length:336
Mass (Da):37,578
Last modified:May 13, 2014 - v3
Checksum:iD6CA349109F6BEE4
GO

Sequence cautioni

The sequence EAW98911.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078993 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98911.1. Sequence problems.
CCDSiCCDS59524.1.
RefSeqiNP_001264236.1. NM_001277307.1.
UniGeneiHs.632792.

Genome annotation databases

EnsembliENST00000400003; ENSP00000382883; ENSG00000182798.
ENST00000400004; ENSP00000382884; ENSG00000182798.
GeneIDi645864.
KEGGihsa:645864.
UCSCiuc031tgu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078993 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98911.1. Sequence problems.
CCDSiCCDS59524.1.
RefSeqiNP_001264236.1. NM_001277307.1.
UniGeneiHs.632792.

3D structure databases

ProteinModelPortaliA8MXT2.
SMRiA8MXT2. Positions 101-311.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA8MXT2.

Proteomic databases

PaxDbiA8MXT2.
PRIDEiA8MXT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400003; ENSP00000382883; ENSG00000182798.
ENST00000400004; ENSP00000382884; ENSG00000182798.
GeneIDi645864.
KEGGihsa:645864.
UCSCiuc031tgu.1. human.

Organism-specific databases

CTDi645864.
GeneCardsiGC0XP016183.
HGNCiHGNC:17418. MAGEB17.
HPAiHPA003756.
MIMi300763. gene.
neXtProtiNX_A8MXT2.
PharmGKBiPA134872991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG266245.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiA8MXT2.
OMAiWECLNAL.
OrthoDBiEOG75F4GM.
PhylomeDBiA8MXT2.
TreeFamiTF328505.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiA8MXT2.
GenevestigatoriA8MXT2.

Family and domain databases

InterProiIPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMAGBH_HUMAN
AccessioniPrimary (citable) accession number: A8MXT2
Secondary accession number(s): A6NE98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 28, 2008
Last sequence update: May 13, 2014
Last modified: January 6, 2015
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Formerly thought to be the product of a pseudogene, although could be a bona fide protein. However, scarce EST evidence confirms only the C-terminal sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.