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A8MXT2 (MAGBH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen B17
Gene names
Name:MAGEB17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 1 MAGE domain.

Caution

Formerly thought to be the product of a pseudogene, although could be a bona fide protein. However, scarce EST evidence confirms only the C-terminal sequence. The N-terminal sequence is based on a computational prediction and so it is uncertain whether Met-1 or Met-122 is the initiator.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Melanoma-associated antigen B17
PRO_0000332218

Regions

Domain230 – 429200MAGE

Experimental info

Sequence conflict561V → I in EAW98911. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A8MXT2 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: B6D07C4855DDE2B2

FASTA45751,128
        10         20         30         40         50         60 
MKHAGECHGQ GAILCKVCGR KTVKEIAGIW HFPGSLELMR QEPRCEAPCR RTEDTVIPEY 

        70         80         90        100        110        120 
WRSNRDQPVA ALRLRGPQAG LRLSISTIIL QGSQEHERFQ EDKLRCPPPA PSCLLPLSTV 

       130        140        150        160        170        180 
IMPRGQASKR RAREKRRQAR GEDQCLGGAQ ATAAEKEKLP SSSSPACQSP PQSFPNAGIP 

       190        200        210        220        230        240 
QESQRASYPS SPASAVSLTS SDEGAKGQKG ESPNSFHGPS SSESTGRDLL NTKTGELVQF 

       250        260        270        280        290        300 
LLNKYIRKEP ITREAMLKVI NRKYKQHFPE ILRRSTENVE VVFGLYLKEM DPSRQSYVLV 

       310        320        330        340        350        360 
GKLDFPNQGS LSDGGGFPLS GLLMVLLSTI FMHGNRATEE EMWECLNALG MYKGRKHFIY 

       370        380        390        400        410        420 
GEPQELVTKD LVREGYLEYQ QVPSSDPPRY EFLWGPRARA ETSKMKVLEF VAKLNDTVAS 

       430        440        450 
TYKSRYEEAL REEEEQARAR AVARDSARAR ASRSFQP 

« Hide

References

[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC078993 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98911.1.
UniGeneHs.632792.

3D structure databases

ProteinModelPortalA8MXT2.
SMRA8MXT2. Positions 222-432.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA8MXT2.

Proteomic databases

PaxDbA8MXT2.
PRIDEA8MXT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329538; ENSP00000328274; ENSG00000182798.
ENST00000400003; ENSP00000382883; ENSG00000182798.
ENST00000400004; ENSP00000382884; ENSG00000182798.
UCSCuc031tgu.1. human.

Organism-specific databases

GeneCardsGC0XP016183.
HGNCHGNC:17418. MAGEB17.
HPAHPA003756.
MIM300763. gene.
neXtProtNX_A8MXT2.
PharmGKBPA134872991.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG266245.
HOGENOMHOG000231161.
HOVERGENHBG006315.
InParanoidA8MXT2.
OrthoDBEOG75F4GM.
PhylomeDBA8MXT2.
TreeFamTF328505.

Gene expression databases

BgeeA8MXT2.
GenevestigatorA8MXT2.

Family and domain databases

InterProIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERPTHR11736. PTHR11736. 1 hit.
PfamPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameMAGBH_HUMAN
AccessionPrimary (citable) accession number: A8MXT2
Secondary accession number(s): A6NE98
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM