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Protein

V-set and transmembrane domain-containing protein 5

Gene

VSTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 5
Gene namesi
Name:VSTM5
Synonyms:C11orf90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:34443. VSTM5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 147119ExtracellularSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 20032CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716741.

Polymorphism and mutation databases

BioMutaiVSTM5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 200172V-set and transmembrane domain-containing protein 5PRO_0000340693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA8MXK1.
PRIDEiA8MXK1.

PTM databases

iPTMnetiA8MXK1.
PhosphoSiteiA8MXK1.

Expressioni

Gene expression databases

BgeeiENSG00000214376.
ExpressionAtlasiA8MXK1. baseline and differential.

Organism-specific databases

HPAiHPA029525.

Structurei

3D structure databases

ProteinModelPortaliA8MXK1.
SMRiA8MXK1. Positions 45-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 139103Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IISJ. Eukaryota.
ENOG410YMAB. LUCA.
GeneTreeiENSGT00390000002299.
InParanoidiA8MXK1.
OMAiTIEWKYT.
OrthoDBiEOG091G0MP5.
PhylomeDBiA8MXK1.
TreeFamiTF332950.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MXK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLPSGRRK TRGISLGLFA LCLAAARCLQ SQGVSLYIPQ ATINATVKED
60 70 80 90 100
ILLSVEYSCH GVPTIEWTYS SNWGTQKIVE WKPGTQANIS QSHKDRVCTF
110 120 130 140 150
DNGSIQLFSV GVRDSGYYVI TVTERLGSSQ FGTIVLHVSE ILYEDLHFVA
160 170 180 190 200
VILAFLAAVA AVLISLMWVC NKCAYKFQRK RRHKLKESTT EEIELEDVEC
Length:200
Mass (Da):22,377
Last modified:December 4, 2007 - v1
Checksum:i8B9EAF98C276CC89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001894 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66922.1.
CCDSiCCDS44709.1.
RefSeqiNP_001138343.1. NM_001144871.1.
UniGeneiHs.512252.

Genome annotation databases

EnsembliENST00000409977; ENSP00000386607; ENSG00000214376.
GeneIDi387804.
KEGGihsa:387804.
UCSCiuc010ruc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001894 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66922.1.
CCDSiCCDS44709.1.
RefSeqiNP_001138343.1. NM_001144871.1.
UniGeneiHs.512252.

3D structure databases

ProteinModelPortaliA8MXK1.
SMRiA8MXK1. Positions 45-139.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA8MXK1.
PhosphoSiteiA8MXK1.

Polymorphism and mutation databases

BioMutaiVSTM5.

Proteomic databases

PaxDbiA8MXK1.
PRIDEiA8MXK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409977; ENSP00000386607; ENSG00000214376.
GeneIDi387804.
KEGGihsa:387804.
UCSCiuc010ruc.2. human.

Organism-specific databases

CTDi387804.
GeneCardsiVSTM5.
HGNCiHGNC:34443. VSTM5.
HPAiHPA029525.
neXtProtiNX_A8MXK1.
PharmGKBiPA164716741.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IISJ. Eukaryota.
ENOG410YMAB. LUCA.
GeneTreeiENSGT00390000002299.
InParanoidiA8MXK1.
OMAiTIEWKYT.
OrthoDBiEOG091G0MP5.
PhylomeDBiA8MXK1.
TreeFamiTF332950.

Miscellaneous databases

GenomeRNAii387804.
PROiA8MXK1.

Gene expression databases

BgeeiENSG00000214376.
ExpressionAtlasiA8MXK1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVSTM5_HUMAN
AccessioniPrimary (citable) accession number: A8MXK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.