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Protein
Submitted name:

General transcription and DNA repair factor IIH helicase subunit XPD

Gene

ERCC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
General transcription and DNA repair factor IIH helicase subunit XPDImported
Gene namesi
Name:ERCC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104884.14
HGNCiHGNC:3434 ERCC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104884

PTM / Processingi

Proteomic databases

EPDiA8MX75
MaxQBiA8MX75
PeptideAtlasiA8MX75
PRIDEiA8MX75

Expressioni

Gene expression databases

BgeeiENSG00000104884
ExpressionAtlasiA8MX75 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA8MX75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 259Helicase ATP-bindingInterPro annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 76Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1131 Eukaryota
COG1199 LUCA
GeneTreeiENSGT00550000075092
HOGENOMiHOG000205390
HOVERGENiHBG051498

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR010643 HBB
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
IPR001945 RAD3/XPD
PANTHERiPTHR11472:SF1 PTHR11472:SF1, 1 hit
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF06777 HBB, 1 hit
PF13307 Helicase_C_2, 1 hit
PRINTSiPR00852 XRODRMPGMNTD
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Fragment.

A8MX75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRELKRTLDA KGHGVLEMPS GTGKTVSLLA LIMAYQRAYP LEVTKLIYCS
60 70 80 90 100
RTVPEIEKVI EELRKLLNFY EKQEGEKLPF LGLALSSRKN LCIHPEVTPL
110 120 130 140 150
RFGKDVDGKC HSLTASYVRA QYQHDTSLPH CRFYEEFDAH GREVPLPAGI
160 170 180 190 200
YNLDDLKALG RRQGWCPYFL ARYSILHANV VVYSYHYLLD PKIADLVSKE
210 220 230 240 250
LARKAVVVFD EAHNIDNVCI DSMSVNLTRR TLDRCQGNLE TLQKTVLRIK
260 270 280 290 300
ETDEQRLRDE YRRLVEGLRE ASAARETDAH LANPVLPDEV LQEAVPGSIR
310 320 330 340 350
TAEHFLGFLR RLLEYVKWRL RVQHVVQESP PAFLSGLAQR VCIQRKPLRF
360 370 380 390 400
CAERLRSLLH TLEITDLADF SPLTLLANFA TLVSTYAKGF TIIIEPFDDR
410 420 430 440 450
TPTIANPILH FSCMDASLAI KPVFERFQSV IITSGTLSPL DIYPKILDFH
460 470 480 490 500
PVTMATFTMT LARVCLCPMI IGRGNDQVAI SSKFETREDI AVIRNYGNLL
510 520 530 540 550
LEMSAVVPDG IVAFFTSYQY MESTVASWYE QGILENIQRN KLLFIETQDG
560 570 580 590 600
AETSVALEKY QEACENGRGA ILLSVARGKV SEGIDFVHHY GRAVIMFGVP
610 620 630 640 650
YVYTQSRILK ARLEYLRDQF QIRENDFLTF DAMRHAAQCV GRAIRGKTDY
660 670 680 690 700
GLMVFADKRF ARGDKRGKLP RWIQEHLTDA NLNLTVDEGV QVAKYFLRQM

AQPFHR
Length:706
Mass (Da):80,512
Last modified:January 9, 2013 - v2
Checksum:i75509B999489FBAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei706Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000391941; ENSP00000375805; ENSG00000104884
UCSCiuc002pbk.3 human

Similar proteinsi

Entry informationi

Entry nameiA8MX75_HUMAN
AccessioniPrimary (citable) accession number: A8MX75
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: January 9, 2013
Last modified: March 28, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health