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Protein

UPF0577 protein KIAA1324-like

Gene

KIAA1324L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0577 protein KIAA1324-like
Alternative name(s):
Estrogen-induced gene 121-like protein
Short name:
hEIG121L
Gene namesi
Name:KIAA1324L
Synonyms:EIG121L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164659.14
HGNCiHGNC:21945 KIAA1324L
MIMi614048 gene
neXtProtiNX_A8MWY0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 929ExtracellularSequence analysisAdd BLAST882
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Topological domaini951 – 1029CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164659
PharmGKBiPA142671608

Polymorphism and mutation databases

BioMutaiKIAA1324L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
ChainiPRO_000033379848 – 1029UPF0577 protein KIAA1324-likeAdd BLAST982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi293 ↔ 310By similarity
Disulfide bondi323 ↔ 346By similarity
Disulfide bondi326 ↔ 358By similarity
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1018PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiA8MWY0
MaxQBiA8MWY0
PaxDbiA8MWY0
PRIDEiA8MWY0

PTM databases

iPTMnetiA8MWY0
PhosphoSitePlusiA8MWY0

Expressioni

Gene expression databases

BgeeiENSG00000164659
CleanExiHS_KIAA1324L
ExpressionAtlasiA8MWY0 baseline and differential
GenevisibleiA8MWY0 HS

Organism-specific databases

HPAiHPA044527
HPA076093

Interactioni

Protein-protein interaction databases

BioGridi128789, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliA8MWY0
SMRiA8MWY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0577 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR7A Eukaryota
ENOG410XVXU LUCA
GeneTreeiENSGT00390000011781
HOGENOMiHOG000006645
HOVERGENiHBG058349
InParanoidiA8MWY0
OMAiKKDCPPC
OrthoDBiEOG091G0162
PhylomeDBiA8MWY0
TreeFamiTF315906

Family and domain databases

InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 4 hits
SUPFAMiSSF57184 SSF57184, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MWY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFRARGPVR GRGWGRPAEA PRRGRSPPWS PAWICCWALA GCQAAWAGDL
60 70 80 90 100
PSSSSRPLPP CQEKDYHFEY TECDSSGSRW RVAIPNSAVD CSGLPDPVRG
110 120 130 140 150
KECTFSCASG EYLEMKNQVC SKCGEGTYSL GSGIKFDEWD ELPAGFSNIA
160 170 180 190 200
TFMDTVVGPS DSRPDGCNNS SWIPRGNYIE SNRDDCTVSL IYAVHLKKSG
210 220 230 240 250
YVFFEYQYVD NNIFFEFFIQ NDQCQEMDTT TDKWVKLTDN GEWGSHSVML
260 270 280 290 300
KSGTNILYWR TTGILMGSKA VKPVLVKNIT IEGVAYTSEC FPCKPGTFSN
310 320 330 340 350
KPGSFNCQVC PRNTYSEKGA KECIRCKDDS QFSEEGSSEC TERPPCTTKD
360 370 380 390 400
YFQIHTPCDE EGKTQIMYKW IEPKICREDL TDAIRLPPSG EKKDCPPCNP
410 420 430 440 450
GFYNNGSSSC HPCPPGTFSD GTKECRPCPA GTEPALGFEY KWWNVLPGNM
460 470 480 490 500
KTSCFNVGNS KCDGMNGWEV AGDHIQSGAG GSDNDYLILN LHIPGFKPPT
510 520 530 540 550
SMTGATGSEL GRITFVFETL CSADCVLYFM VDINRKSTNV VESWGGTKEK
560 570 580 590 600
QAYTHIIFKN ATFTFTWAFQ RTNQGQDNRR FINDMVKIYS ITATNAVDGV
610 620 630 640 650
ASSCRACALG SEQSGSSCVP CPPGHYIEKE TNQCKECPPD TYLSIHQVYG
660 670 680 690 700
KEACIPCGPG SKNNQDHSVC YSDCFFYHEK ENQSLHYDFS NLSSVGSLMN
710 720 730 740 750
GPSFTSKGTK YFHFFNISLC GHEGKKMALC TNNITDFTVK EIVAGSDDYT
760 770 780 790 800
NLVGAFVCQS TIIPSESKGF RAALSSQSII LADTFIGVTV ETTLKNINIK
810 820 830 840 850
EDMFPVPTSQ IPDVHFFYKS STATTSCING RSTAVKMRCN PTKSGAGVIS
860 870 880 890 900
VPSKCPAGTC DGCTFYFLWE SAEACPLCTE HDFHEIEGAC KRGFQETLYV
910 920 930 940 950
WNEPKWCIKG ISLPEKKLAT CETVDFWLKV GAGVGAFTAV LLVALTCYFW
960 970 980 990 1000
KKNQKLEYKY SKLVMTTNSK ECELPAADSC AIMEGEDNEE EVVYSNKQSL
1010 1020
LGKLKSLATK EKEDHFESVQ LKTSRSPNI
Length:1,029
Mass (Da):113,842
Last modified:May 20, 2008 - v2
Checksum:iBF7E919BAB202DAF
GO
Isoform 2 (identifier: A8MWY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-247: GEWGSHS → MLEGNYQ

Note: No experimental confirmation available.
Show »
Length:789
Mass (Da):87,063
Checksum:i08BA2D080B8DAE64
GO
Isoform 3 (identifier: A8MWY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     168-169: NN → MH

Note: No experimental confirmation available.
Show »
Length:862
Mass (Da):95,750
Checksum:i16E6507AA41EEDF9
GO

Sequence cautioni

The sequence AAI17310 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71041 differs from that shown. Reason: Frameshift at position 719.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti678H → P in BAB71041 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043161539N → Y. Corresponds to variant dbSNP:rs1029366Ensembl.1
Natural variantiVAR_043162729L → V. Corresponds to variant dbSNP:rs34412146Ensembl.1
Natural variantiVAR_043163767S → R. Corresponds to variant dbSNP:rs34577440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335291 – 240Missing in isoform 2. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_0432541 – 167Missing in isoform 3. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_043255168 – 169NN → MH in isoform 3. 1 Publication2
Alternative sequenceiVSP_033530241 – 247GEWGSHS → MLEGNYQ in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055902 mRNA Translation: BAB71041.1 Frameshift.
AK296250 mRNA Translation: BAG58965.1
AC000122 Genomic DNA No translation available.
AC002081 Genomic DNA No translation available.
AC004519 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24181.1
CH471091 Genomic DNA Translation: EAW76969.1
BC117309 mRNA Translation: AAI17310.1 Different initiation.
CCDSiCCDS34677.2 [A8MWY0-3]
CCDS47632.1 [A8MWY0-1]
RefSeqiNP_001136221.1, NM_001142749.2 [A8MWY0-1]
NP_001278920.1, NM_001291991.1 [A8MWY0-2]
NP_689961.3, NM_152748.3 [A8MWY0-3]
XP_016867333.1, XM_017011844.1 [A8MWY0-3]
UniGeneiHs.208093

Genome annotation databases

EnsembliENST00000416314; ENSP00000402390; ENSG00000164659 [A8MWY0-3]
ENST00000450689; ENSP00000413445; ENSG00000164659 [A8MWY0-1]
GeneIDi222223
KEGGihsa:222223
UCSCiuc003uie.5 human [A8MWY0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK132L_HUMAN
AccessioniPrimary (citable) accession number: A8MWY0
Secondary accession number(s): A4D1C9
, B4DJV3, Q17RI6, Q96DP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 28, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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