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A8MWL7

- TM14D_HUMAN

UniProt

A8MWL7 - TM14D_HUMAN

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Protein

Transmembrane protein 14D

Gene

TMEM14D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14D
Gene namesi
Name:TMEM14D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15660. TMEM14D.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Transmembrane protein 14DPRO_0000344255Add
BLAST

Proteomic databases

PRIDEiA8MWL7.

Expressioni

Gene expression databases

GenevestigatoriA8MWL7.

Structurei

3D structure databases

ProteinModelPortaliA8MWL7.
SMRiA8MWL7. Positions 8-110.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8018HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0136 (TMEM14) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054211.
InParanoidiA8MWL7.
PhylomeDBiA8MWL7.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MWL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGRAPSLA AGLLFGSLAG
60 70 80 90 100
VGAYQLYQDP RNVWDFLAAT SVTFVGIMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Length:114
Mass (Da):12,177
Last modified:July 22, 2008 - v2
Checksum:iC123D10033A0160E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081R → C.
Corresponds to variant rs5030881 [ dbSNP | Ensembl ].
VAR_045605

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL713888 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL713888 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali A8MWL7.
SMRi A8MWL7. Positions 8-110.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A8MWL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC10M070303.
HGNCi HGNC:15660. TMEM14D.
neXtProti NX_A8MWL7.
PharmGKBi PA134907907.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG054211.
InParanoidi A8MWL7.
PhylomeDBi A8MWL7.

Miscellaneous databases

NextBioi 21547107.
PROi A8MWL7.

Gene expression databases

Genevestigatori A8MWL7.

Family and domain databases

InterProi IPR005349. UPF0136_TM.
[Graphical view ]
PANTHERi PTHR12668. PTHR12668. 1 hit.
Pfami PF03647. Tmemb_14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTM14D_HUMAN
AccessioniPrimary (citable) accession number: A8MWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3