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A8MWL7

- TM14D_HUMAN

UniProt

A8MWL7 - TM14D_HUMAN

Protein

Transmembrane protein 14D

Gene

TMEM14D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 14D
    Gene namesi
    Name:TMEM14D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:15660. TMEM14D.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134907907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 114114Transmembrane protein 14DPRO_0000344255Add
    BLAST

    Proteomic databases

    PRIDEiA8MWL7.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MWL7.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MWL7.
    SMRiA8MWL7. Positions 8-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0136 (TMEM14) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG054211.
    InParanoidiA8MWL7.
    PhylomeDBiA8MWL7.

    Family and domain databases

    InterProiIPR005349. UPF0136_TM.
    [Graphical view]
    PANTHERiPTHR12668. PTHR12668. 1 hit.
    PfamiPF03647. Tmemb_14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MWL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGRAPSLA AGLLFGSLAG    50
    VGAYQLYQDP RNVWDFLAAT SVTFVGIMGM RSYYYGKFMP VGLIAGASLL 100
    MAAKVGVRML MTSD 114
    Length:114
    Mass (Da):12,177
    Last modified:July 22, 2008 - v2
    Checksum:iC123D10033A0160E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081R → C.
    Corresponds to variant rs5030881 [ dbSNP | Ensembl ].
    VAR_045605

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL713888 Genomic DNA. No translation available.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL713888 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A8MWL7.
    SMRi A8MWL7. Positions 8-110.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A8MWL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC10M070303.
    HGNCi HGNC:15660. TMEM14D.
    neXtProti NX_A8MWL7.
    PharmGKBi PA134907907.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG054211.
    InParanoidi A8MWL7.
    PhylomeDBi A8MWL7.

    Miscellaneous databases

    NextBioi 21547107.
    PROi A8MWL7.

    Gene expression databases

    Genevestigatori A8MWL7.

    Family and domain databases

    InterProi IPR005349. UPF0136_TM.
    [Graphical view ]
    PANTHERi PTHR12668. PTHR12668. 1 hit.
    Pfami PF03647. Tmemb_14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTM14D_HUMAN
    AccessioniPrimary (citable) accession number: A8MWL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3