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Protein

Putative fatty acid desaturase 2-like protein FADS2P1

Gene

FADS2P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi113Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid desaturase 2-like protein FADS2P1
Alternative name(s):
Fatty acid desaturase 2 pseudogene 1
Gene namesi
Name:FADS2P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:43618. FADS2P1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 167CytoplasmicSequence analysisAdd BLAST167
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 190LumenalSequence analysis2
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 305CytoplasmicSequence analysisAdd BLAST94
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 343LumenalSequence analysisAdd BLAST17
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 482CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489571 – 482Putative fatty acid desaturase 2-like protein FADS2P1Add BLAST482

Proteomic databases

PRIDEiA8MWK0.

Structurei

3D structure databases

ProteinModelPortaliA8MWK0.
SMRiA8MWK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 132Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 221Histidine box-15
Motifi254 – 258Histidine box-25
Motifi421 – 425Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002839.
InParanoidiA8MWK0.
PhylomeDBiA8MWK0.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MWK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFEEKCGDN GSIVGRNQSY PGEKHQPKGK PIANGEAEVY AKQEANGKCS
60 70 80 90 100
TPRKSLSMYT WLEIQRHNHE ADQLVINCKV YNVSSWADRH PGGHQVLNHC
110 120 130 140 150
AGEDAMDVFR AMHPELDIVQ LYLKPLLIGE LAPGEPSQER HKNSQLVKDF
160 170 180 190 200
QELWSIAEAM NMFHANLGFF FLHFVQILIL EVLAWLIVYH FGSGWPVTMF
210 220 230 240 250
ISFLLTISQA SSSFLQHDAG HLSIFRKSKW NHVVHKFVMC HLKGLSADRW
260 270 280 290 300
NYWHFEQHVK PNIYPKDPDI DTDPLFLLGD SQPVKYGKKK IKYINYEEQH
310 320 330 340 350
LYFYKVWLPL FMPVYLKLPS MQAMYLQRYW VCFSLQDITW VSSFYIYFIT
360 370 380 390 400
FGLYYGIFGT MLLIYLVKFL ESPWIVYVTQ MSHITMRMST EENRDWLTTQ
410 420 430 440 450
VLATCNTESF FNDFTGHLNF QIEHHLFPTM PRHNYHKVAP LVRSLCAKHG
460 470 480
LHYVNKPMLR AFGDIVRALK KSAALWADAY YE
Length:482
Mass (Da):56,358
Last modified:September 2, 2008 - v2
Checksum:i8036A3CABC5D8751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000479 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000479 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA8MWK0.
SMRiA8MWK0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA8MWK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiFADS2P1.
HGNCiHGNC:43618. FADS2P1.
neXtProtiNX_A8MWK0.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG002839.
InParanoidiA8MWK0.
PhylomeDBiA8MWK0.

Enzyme and pathway databases

UniPathwayiUPA00658.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFS2P1_HUMAN
AccessioniPrimary (citable) accession number: A8MWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.