ID   EFCB8_HUMAN             Reviewed;         144 AA.
AC   A8MWE9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=EF-hand calcium-binding domain-containing protein 8;
GN   Name=EFCAB8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
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DR   EMBL; AL390298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MWE9; -.
DR   SMR; A8MWE9; -.
DR   STRING; 9606.ENSP00000383366; -.
DR   PhosphoSitePlus; A8MWE9; -.
DR   BioMuta; EFCAB8; -.
DR   PaxDb; 9606-ENSP00000383366; -.
DR   PeptideAtlas; A8MWE9; -.
DR   Antibodypedia; 59265; 6 antibodies from 6 providers.
DR   Ensembl; ENST00000618684.1; ENSP00000481567.1; ENSG00000215529.13.
DR   UCSC; uc061wfk.1; human.
DR   AGR; HGNC:34532; -.
DR   GeneCards; EFCAB8; -.
DR   HGNC; HGNC:34532; EFCAB8.
DR   HPA; ENSG00000215529; Tissue enriched (testis).
DR   neXtProt; NX_A8MWE9; -.
DR   OpenTargets; ENSG00000215529; -.
DR   VEuPathDB; HostDB:ENSG00000215529; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   GeneTree; ENSGT00940000163617; -.
DR   HOGENOM; CLU_120283_0_0_1; -.
DR   InParanoid; A8MWE9; -.
DR   OMA; MQPGKIH; -.
DR   PhylomeDB; A8MWE9; -.
DR   TreeFam; TF353054; -.
DR   SignaLink; A8MWE9; -.
DR   ChiTaRS; EFCAB8; human.
DR   Pharos; A8MWE9; Tdark.
DR   PRO; PR:A8MWE9; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; A8MWE9; Protein.
DR   Bgee; ENSG00000215529; Expressed in primordial germ cell in gonad and 73 other cell types or tissues.
DR   ExpressionAtlas; A8MWE9; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR44324:SF6; EF-HAND CALCIUM-BINDING DOMAIN 8; 1.
DR   PANTHER; PTHR44324; WD40 REPEAT DOMAIN 95; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Reference proteome; Repeat.
FT   CHAIN           1..144
FT                   /note="EF-hand calcium-binding domain-containing protein 8"
FT                   /id="PRO_0000340678"
FT   DOMAIN          52..86
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          87..122
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   144 AA;  16428 MW;  BA081DF55B37B0BB CRC64;
     MSSEDLAEIP QLQKLSIPHG FQNKEAASSP TPSITLSQVP DLQPGSQLFT EIHLAKIEKM
     FEEDINSTGA LGMDAFIKAM KKVLSSVSDE MLKELFLKVD SDCEGFVTWQ KYVDYMMREF
     QGKEDMRKSQ YRLHFYLPMT VVPL
//