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A8MWE9

- EFCB8_HUMAN

UniProt

A8MWE9 - EFCB8_HUMAN

Protein

EF-hand calcium-binding domain-containing protein 8

Gene

EFCAB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EF-hand calcium-binding domain-containing protein 8
    Gene namesi
    Name:EFCAB8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:34532. EFCAB8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144EF-hand calcium-binding domain-containing protein 8PRO_0000340678Add
    BLAST

    Proteomic databases

    PaxDbiA8MWE9.
    PRIDEiA8MWE9.

    PTM databases

    PhosphoSiteiA8MWE9.

    Expressioni

    Gene expression databases

    BgeeiA8MWE9.
    GenevestigatoriA8MWE9.

    Organism-specific databases

    HPAiCAB034246.
    HPA042751.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MWE9.
    SMRiA8MWE9. Positions 50-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 8635EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 12236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOVERGENiHBG107837.
    InParanoidiA8MWE9.
    PhylomeDBiA8MWE9.
    TreeFamiTF353054.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MWE9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEDLAEIP QLQKLSIPHG FQNKEAASSP TPSITLSQVP DLQPGSQLFT    50
    EIHLAKIEKM FEEDINSTGA LGMDAFIKAM KKVLSSVSDE MLKELFLKVD 100
    SDCEGFVTWQ KYVDYMMREF QGKEDMRKSQ YRLHFYLPMT VVPL 144
    Length:144
    Mass (Da):16,428
    Last modified:June 10, 2008 - v2
    Checksum:iBA081DF55B37B0BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL390298 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000400522; ENSP00000383366; ENSG00000215529.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL390298 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A8MWE9.
    SMRi A8MWE9. Positions 50-113.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A8MWE9.

    Proteomic databases

    PaxDbi A8MWE9.
    PRIDEi A8MWE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400522 ; ENSP00000383366 ; ENSG00000215529 .

    Organism-specific databases

    GeneCardsi GC20P031446.
    HGNCi HGNC:34532. EFCAB8.
    HPAi CAB034246.
    HPA042751.
    neXtProti NX_A8MWE9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOVERGENi HBG107837.
    InParanoidi A8MWE9.
    PhylomeDBi A8MWE9.
    TreeFami TF353054.

    Gene expression databases

    Bgeei A8MWE9.
    Genevestigatori A8MWE9.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiEFCB8_HUMAN
    AccessioniPrimary (citable) accession number: A8MWE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3