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Protein

Putative zinc finger protein 705E

Gene

ZNF705E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 705E
Gene namesi
Name:ZNF705E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33203. ZNF705E.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Putative zinc finger protein 705EPRO_0000343575Add
BLAST

Proteomic databases

PeptideAtlasiA8MWA4.
PRIDEiA8MWA4.

PTM databases

iPTMnetiA8MWA4.
PhosphoSiteiA8MWA4.

Structurei

3D structure databases

ProteinModelPortaliA8MWA4.
SMRiA8MWA4. Positions 7-51, 117-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8074KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri174 – 19623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiA8MWA4.
PhylomeDBiA8MWA4.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MWA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLKKVTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLVTGY
60 70 80 90 100
QISKSYIILQ LEQGKELWQE GREFLQDQNP DRESALKKTH MISMHPIIRK
110 120 130 140 150
DAPTSMTMEN SLILEDPFEC NDSGEDCTHS STIIQCLLTH SGKKPYVSKQ
160 170 180 190 200
CGKSLSNLLS PKPHKQIHTK GKSYQCNLCE KAYTNCFHLR RPKMTHTGER
210 220 230 240 250
PYTCHLCRKA FTQCSHLRRH EKTHTGERPY KCHQCGKAFI QSFNLRRHER
260 270 280 290 300
THLGEKWYEC DNSGKAFSQS SGFRGNKIIH TGEKPHACLL CGKAFSLSSD

LR
Length:302
Mass (Da):34,897
Last modified:December 4, 2007 - v1
Checksum:i42319A95175FE767
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002495 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002495 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA8MWA4.
SMRiA8MWA4. Positions 7-51, 117-302.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA8MWA4.
PhosphoSiteiA8MWA4.

Proteomic databases

PeptideAtlasiA8MWA4.
PRIDEiA8MWA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiZNF705E.
HGNCiHGNC:33203. ZNF705E.
neXtProtiNX_A8MWA4.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiA8MWA4.
PhylomeDBiA8MWA4.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

PROiA8MWA4.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZ705E_HUMAN
AccessioniPrimary (citable) accession number: A8MWA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.