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Protein

Beclin-2

Gene

BECN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.1 Publication

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • autophagy Source: UniProtKB
  • cellular response to nitrogen starvation Source: GO_Central
  • CVT pathway Source: GO_Central
  • endosome to lysosome transport Source: UniProtKB
  • glucose homeostasis Source: Ensembl
  • G-protein coupled receptor catabolic process Source: UniProtKB
  • late endosome to vacuole transport Source: GO_Central
  • nucleophagy Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Beclin-21 Publication
Alternative name(s):
Beclin-1 autophagy-related pseudogene 1Imported
Beclin-1-like protein 1Imported
Gene namesi
Name:BECN21 PublicationImported
Synonyms:BECN1L1Imported, BECN1P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:38606. BECN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi80 – 801I → S: Abolishes interaction with GPRASP1/GASP1 and ability to degrade G-protein coupled receptor. Does not affect function in autophagy. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Beclin-2PRO_0000332244Add
BLAST

Proteomic databases

PRIDEiA8MW95.

PTM databases

iPTMnetiA8MW95.
PhosphoSiteiA8MW95.

Expressioni

Tissue specificityi

Present in fetal and adult brain (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with ATG14, AMBRA1, UVRAG and PIK3C3/VPS34; interaction is not disrupted by starvation. Does not interact with RUBCN. Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GPRASP1Q5JY774EBI-8839517,EBI-2514717

Protein-protein interaction databases

IntActiA8MW95. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliA8MW95.
SMRiA8MW95. Positions 177-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 248124Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the beclin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000008164.
HOVERGENiHBG003181.
InParanoidiA8MW95.

Family and domain databases

InterProiIPR007243. Atg6/Beclin.
IPR032912. BECN2.
[Graphical view]
PANTHERiPTHR12768. PTHR12768. 1 hit.
PTHR12768:SF5. PTHR12768:SF5. 1 hit.
PfamiPF04111. APG6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MW95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIRFLCQR CHQALKLSGS SESRSLPAAP APTSGQAEPG DTREPGVTTR
60 70 80 90 100
EVTDAEEQQD GASSRSPPGD GSVSKGHANI FTLLGELGAM HMLSSIQKAA
110 120 130 140 150
GDIFDIVSGQ AVVDHPLCEE CTDSLLEQLD IQLALTEADS QNYQRCLETG
160 170 180 190 200
ELATSEDEAA ALRAELRDLE LEEARLVQEL EDVDRNNARA AADLQAAQAE
210 220 230 240 250
AAELDQQERQ HYRDYSALKR QQLELLDQLG NVENQLQYAR VQRDRLKEIN
260 270 280 290 300
CFTATFEIWV EGPLGVINNF RLGRLPTVRV GWNEINTAWG QAALLLLTLA
310 320 330 340 350
NTIGLQFQRY RLIPCGNHSY LKSLTDDRTE LPLFCYGGQD VFLNNKYDRA
360 370 380 390 400
MVAFLDCMQQ FKEEAEKGEL GLSLPYGIQV ETGLMEDVGG RGECYSIRTH
410 420 430
LNTQELWTKA LKFMLINFKW SLIWVASRYQ K
Length:431
Mass (Da):48,153
Last modified:October 31, 2012 - v2
Checksum:i9DB4184BE5C7A574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM031116 mRNA. Translation: ADM47406.1.
BX571673 Genomic DNA. No translation available.
RefSeqiNP_001277622.1. NM_001290693.1.
UniGeneiHs.731347.

Genome annotation databases

EnsembliENST00000419583; ENSP00000488361; ENSG00000196289.
GeneIDi441925.
KEGGihsa:441925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM031116 mRNA. Translation: ADM47406.1.
BX571673 Genomic DNA. No translation available.
RefSeqiNP_001277622.1. NM_001290693.1.
UniGeneiHs.731347.

3D structure databases

ProteinModelPortaliA8MW95.
SMRiA8MW95. Positions 177-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA8MW95. 6 interactions.

PTM databases

iPTMnetiA8MW95.
PhosphoSiteiA8MW95.

Proteomic databases

PRIDEiA8MW95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419583; ENSP00000488361; ENSG00000196289.
GeneIDi441925.
KEGGihsa:441925.

Organism-specific databases

CTDi441925.
GeneCardsiBECN2.
HGNCiHGNC:38606. BECN2.
MIMi615687. gene.
neXtProtiNX_A8MW95.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008164.
HOVERGENiHBG003181.
InParanoidiA8MW95.

Miscellaneous databases

GenomeRNAii441925.
PROiA8MW95.
SOURCEiSearch...

Family and domain databases

InterProiIPR007243. Atg6/Beclin.
IPR032912. BECN2.
[Graphical view]
PANTHERiPTHR12768. PTHR12768. 1 hit.
PTHR12768:SF5. PTHR12768:SF5. 1 hit.
PfamiPF04111. APG6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBECN2_HUMAN
AccessioniPrimary (citable) accession number: A8MW95
Secondary accession number(s): E9KNW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 31, 2012
Last modified: June 8, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.