ID   ARG33_HUMAN             Reviewed;         844 AA.
AC   A8MVX0; J3KPX2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=Rho guanine nucleotide exchange factor 33;
GN   Name=ARHGEF33;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-83 (ISOFORM 1/2).
RA   Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT   "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT   human.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 747-844 (ISOFORM 2).
RC   TISSUE=Caudate nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May act as a guanine-nucleotide releasing factor.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8MVX0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8MVX0-2; Sequence=VSP_044905;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DV080278; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC018693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DV080278; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK123375; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS46263.2; -. [A8MVX0-2]
DR   RefSeq; NP_001138923.2; NM_001145451.2. [A8MVX0-2]
DR   AlphaFoldDB; A8MVX0; -.
DR   SMR; A8MVX0; -.
DR   BioGRID; 938496; 4.
DR   STRING; 9606.ENSP00000387020; -.
DR   iPTMnet; A8MVX0; -.
DR   PhosphoSitePlus; A8MVX0; -.
DR   BioMuta; ARHGEF33; -.
DR   MassIVE; A8MVX0; -.
DR   PaxDb; 9606-ENSP00000387020; -.
DR   PeptideAtlas; A8MVX0; -.
DR   ProteomicsDB; 2212; -. [A8MVX0-1]
DR   Antibodypedia; 49385; 62 antibodies from 13 providers.
DR   DNASU; 100271715; -.
DR   Ensembl; ENST00000398800.8; ENSP00000381780.4; ENSG00000214694.13. [A8MVX0-2]
DR   Ensembl; ENST00000409978.7; ENSP00000387020.1; ENSG00000214694.13. [A8MVX0-2]
DR   GeneID; 100271715; -.
DR   KEGG; hsa:100271715; -.
DR   MANE-Select; ENST00000409978.7; ENSP00000387020.1; NM_001145451.5; NP_001138923.2. [A8MVX0-2]
DR   UCSC; uc021vgd.2; human. [A8MVX0-1]
DR   AGR; HGNC:37252; -.
DR   CTD; 100271715; -.
DR   DisGeNET; 100271715; -.
DR   GeneCards; ARHGEF33; -.
DR   HGNC; HGNC:37252; ARHGEF33.
DR   HPA; ENSG00000214694; Tissue enhanced (brain, testis).
DR   neXtProt; NX_A8MVX0; -.
DR   VEuPathDB; HostDB:ENSG00000214694; -.
DR   eggNOG; ENOG502RVY2; Eukaryota.
DR   GeneTree; ENSGT00940000162759; -.
DR   HOGENOM; CLU_018772_0_0_1; -.
DR   InParanoid; A8MVX0; -.
DR   OMA; LEHANMV; -.
DR   OrthoDB; 5363309at2759; -.
DR   PhylomeDB; A8MVX0; -.
DR   PathwayCommons; A8MVX0; -.
DR   Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR   Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR   BioGRID-ORCS; 100271715; 22 hits in 1139 CRISPR screens.
DR   ChiTaRS; ARHGEF33; human.
DR   GenomeRNAi; 100271715; -.
DR   Pharos; A8MVX0; Tdark.
DR   PRO; PR:A8MVX0; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A8MVX0; Protein.
DR   Bgee; ENSG00000214694; Expressed in right hemisphere of cerebellum and 99 other cell types or tissues.
DR   ExpressionAtlas; A8MVX0; baseline and differential.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR042849; ARHGEF33.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR   PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Guanine-nucleotide releasing factor;
KW   Methylation; Reference proteome.
FT   CHAIN           1..844
FT                   /note="Rho guanine nucleotide exchange factor 33"
FT                   /id="PRO_0000342343"
FT   DOMAIN          265..440
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          668..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          787..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          54..129
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        103..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..803
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         757
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BW86"
FT   VAR_SEQ         829..844
FT                   /note="NGNATGEDFCGPWGWW -> SSGSEYREKTNENPSMDPSPTKQDFFRNRLAL
FT                   ANDLDQGTAV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044905"
SQ   SEQUENCE   844 AA;  94633 MW;  790FB919145D5C3E CRC64;
     MEKTKTKQGE NEHMPVNNPS TQIYQLQALA SELKTGFTEA MQELSRIQHG EYALEEKVKS
     CRCSMEEKVT EMKNSLNYFK EELSNAMSMI QAITSKQEEM QQKIEQLQQE KRRESRKVKA
     KKTQKEEHSS QAGPAQAQGS PFRSINIPEP VLPSEDFTNL LPSQAYEKAQ ESRSVHVGDS
     NVKGMMGPGV NPTTPEAEEN LKSCLSADIQ SKGHLPSGMW RQPKDGKEWG EEYVTKDHPD
     KLKEAGQGRH SSLENVLCET SLAAKRQTVA LELLESERKY VINISLILKI KATFQGSDGK
     RNSKERSLFP GSLRYLVQQH LDLLHALQER VLKWPRQGVL GDLFLKLTND ENNFLDYYVA
     YLRDLPECIS LVHVVVLKEG DEEIKSDIYT LFFHIVQRIP EYLIHLQNVL KFTEQEHPDY
     YLLLVCVQRL RVFISHYTLL FQCNEDLLIQ KRKKLKKSSM AKLYKGLASQ CANAGQDASP
     TAGPEAVRDT GIHSEELLQP YPSAPSSGPA ITHLMPPVKK SQQQQSLMES MQPGKPSDWE
     LEGRKHERPE SLLAPTQFCA AEQDVKALAG PLQAIPEMDF ESSPAEPLGN VERSLRAPAE
     LLPDARGFVP AAYEEFEYGG EIFALPAPYD EEPFQAPALF ENCSPASSES SLDICFLRPV
     SFAMEAERPE HPLQPLPKSA TSPAGSSSAY KLEAAAQAHG KAKPLSRSLK EFPRAPPADG
     VAPRLYSTRS SSGGRAPIKA ERAAQAHGPA AAAVAARGAS RTFFPQQRSQ SEKQTYLEVR
     REMHLEDTTR FCPKEERESE QTSFSDQNPR QDQKGGFRSS FRKLFKKKNG NATGEDFCGP
     WGWW
//