A8MVX0 (ARG33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho guanine nucleotide exchange factor 33

Gene names

Name:

ARHGEF33

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	844 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a guanine-nucleotide releasing factor By similarity.
Sequence similarities	Contains 1 DH (DBL-homology) domain.
Sequence caution	The sequence DV080278 differs from that shown. Reason: Frameshift at position 79.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A8MVX0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A8MVX0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     829-844: NGNATGEDFCGPWGWW → SSGSEYREKTNENPSMDPSPTKQDFFRNRLALANDLDQGTAV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 844	844	Rho guanine nucleotide exchange factor 33		PRO_0000342343
Regions
	Domain	265 – 440	176	DH
	Coiled coil	54 – 129	76	Potential
	Compositional bias	522 – 525	4	Poly-Gln
	Compositional bias	750 – 756	7	Poly-Ala
Natural variations
	Alternative sequence	829 – 844	16	NGNAT…PWGWW → SSGSEYREKTNENPSMDPSP TKQDFFRNRLALANDLDQGT AV in isoform 2.		VSP_044905

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: 790FB919145D5C3E	FASTA	844	94,633
	10 20 30 40 50 60 MEKTKTKQGE NEHMPVNNPS TQIYQLQALA SELKTGFTEA MQELSRIQHG EYALEEKVKS 70 80 90 100 110 120 CRCSMEEKVT EMKNSLNYFK EELSNAMSMI QAITSKQEEM QQKIEQLQQE KRRESRKVKA 130 140 150 160 170 180 KKTQKEEHSS QAGPAQAQGS PFRSINIPEP VLPSEDFTNL LPSQAYEKAQ ESRSVHVGDS 190 200 210 220 230 240 NVKGMMGPGV NPTTPEAEEN LKSCLSADIQ SKGHLPSGMW RQPKDGKEWG EEYVTKDHPD 250 260 270 280 290 300 KLKEAGQGRH SSLENVLCET SLAAKRQTVA LELLESERKY VINISLILKI KATFQGSDGK 310 320 330 340 350 360 RNSKERSLFP GSLRYLVQQH LDLLHALQER VLKWPRQGVL GDLFLKLTND ENNFLDYYVA 370 380 390 400 410 420 YLRDLPECIS LVHVVVLKEG DEEIKSDIYT LFFHIVQRIP EYLIHLQNVL KFTEQEHPDY 430 440 450 460 470 480 YLLLVCVQRL RVFISHYTLL FQCNEDLLIQ KRKKLKKSSM AKLYKGLASQ CANAGQDASP 490 500 510 520 530 540 TAGPEAVRDT GIHSEELLQP YPSAPSSGPA ITHLMPPVKK SQQQQSLMES MQPGKPSDWE 550 560 570 580 590 600 LEGRKHERPE SLLAPTQFCA AEQDVKALAG PLQAIPEMDF ESSPAEPLGN VERSLRAPAE 610 620 630 640 650 660 LLPDARGFVP AAYEEFEYGG EIFALPAPYD EEPFQAPALF ENCSPASSES SLDICFLRPV 670 680 690 700 710 720 SFAMEAERPE HPLQPLPKSA TSPAGSSSAY KLEAAAQAHG KAKPLSRSLK EFPRAPPADG 730 740 750 760 770 780 VAPRLYSTRS SSGGRAPIKA ERAAQAHGPA AAAVAARGAS RTFFPQQRSQ SEKQTYLEVR 790 800 810 820 830 840 REMHLEDTTR FCPKEERESE QTSFSDQNPR QDQKGGFRSS FRKLFKKKNG NATGEDFCGP WGWW
	Isoform 2 [UniParc]. Checksum: 9EA51122954F91BB	FASTA	870	97,524
	10 20 30 40 50 60 MEKTKTKQGE NEHMPVNNPS TQIYQLQALA SELKTGFTEA MQELSRIQHG EYALEEKVKS 70 80 90 100 110 120 CRCSMEEKVT EMKNSLNYFK EELSNAMSMI QAITSKQEEM QQKIEQLQQE KRRESRKVKA 130 140 150 160 170 180 KKTQKEEHSS QAGPAQAQGS PFRSINIPEP VLPSEDFTNL LPSQAYEKAQ ESRSVHVGDS 190 200 210 220 230 240 NVKGMMGPGV NPTTPEAEEN LKSCLSADIQ SKGHLPSGMW RQPKDGKEWG EEYVTKDHPD 250 260 270 280 290 300 KLKEAGQGRH SSLENVLCET SLAAKRQTVA LELLESERKY VINISLILKI KATFQGSDGK 310 320 330 340 350 360 RNSKERSLFP GSLRYLVQQH LDLLHALQER VLKWPRQGVL GDLFLKLTND ENNFLDYYVA 370 380 390 400 410 420 YLRDLPECIS LVHVVVLKEG DEEIKSDIYT LFFHIVQRIP EYLIHLQNVL KFTEQEHPDY 430 440 450 460 470 480 YLLLVCVQRL RVFISHYTLL FQCNEDLLIQ KRKKLKKSSM AKLYKGLASQ CANAGQDASP 490 500 510 520 530 540 TAGPEAVRDT GIHSEELLQP YPSAPSSGPA ITHLMPPVKK SQQQQSLMES MQPGKPSDWE 550 560 570 580 590 600 LEGRKHERPE SLLAPTQFCA AEQDVKALAG PLQAIPEMDF ESSPAEPLGN VERSLRAPAE 610 620 630 640 650 660 LLPDARGFVP AAYEEFEYGG EIFALPAPYD EEPFQAPALF ENCSPASSES SLDICFLRPV 670 680 690 700 710 720 SFAMEAERPE HPLQPLPKSA TSPAGSSSAY KLEAAAQAHG KAKPLSRSLK EFPRAPPADG 730 740 750 760 770 780 VAPRLYSTRS SSGGRAPIKA ERAAQAHGPA AAAVAARGAS RTFFPQQRSQ SEKQTYLEVR 790 800 810 820 830 840 REMHLEDTTR FCPKEERESE QTSFSDQNPR QDQKGGFRSS FRKLFKKKSS GSEYREKTNE 850 860 870 NPSMDPSPTK QDFFRNRLAL ANDLDQGTAV

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human." Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-83 (ISOFORM 1/2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 747-844 (ISOFORM 2). Tissue: Caudate nucleus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC018693 Genomic DNA. No translation available. AC019171 Genomic DNA. No translation available. DV080278 mRNA. No translation available. AK123375 mRNA. No translation available.
IPI	IPI00915871.
RefSeq	NP_001138923.2. NM_001145451.2.
UniGene	Hs.99841.
3D structure databases
ProteinModelPortal	A8MVX0.
ModBase	Search...
PTM databases
PhosphoSite	A8MVX0.
Proteomic databases
PaxDb	A8MVX0.
PRIDE	A8MVX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398800; ENSP00000381780; ENSG00000214694. ENST00000409978; ENSP00000387020; ENSG00000214694. ENST00000536934; ENSP00000445586; ENSG00000214694.
GeneID	100271715.
KEGG	hsa:100271715.
UCSC	uc021vgd.1. human.
Organism-specific databases
GeneCards	GC02P039118.
HGNC	HGNC:37252. ARHGEF33.
HPA	HPA034661.
neXtProt	NX_A8MVX0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47910.
HOGENOM	HOG000168823.
HOVERGEN	HBG098090.
InParanoid	A8MVX0.
OMA	SMAKLYK.
OrthoDB	EOG4J3WGC.
Gene expression databases
ArrayExpress	A8MVX0.
Bgee	A8MVX0.
Genevestigator	A8MVX0.
Family and domain databases
Gene3D	1.20.900.10. 1 hit.
InterPro	IPR000219. DH-domain. [Graphical view]
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35535224.

Entry information

Entry name

ARG33_HUMAN

Accession

Primary (citable) accession number: A8MVX0
Secondary accession number(s): J3KPX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.