Reviewed, UniProtKB/Swiss-Prot A8MVW0 (F1712_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAM171A2

Gene names

Name:

FAM171A2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	826 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the FAM171 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 826	797	Protein FAM171A2		PRO_0000328771
Regions
	Topological domain	30 – 315	286	Extracellular Potential
	Transmembrane	316 – 336	21	Potential
	Topological domain	337 – 826	490	Cytoplasmic Potential
	Compositional bias	474 – 480	7	Poly-Pro
	Compositional bias	550 – 607	58	Gly-rich
	Compositional bias	715 – 722	8	Poly-Pro
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Ref.3
	Glycosylation	201	1	N-linked (GlcNAc...) Potential
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A8MVW0-1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 2845FC542702C3E0	FASTA	826	87,435
	10 20 30 40 50 60 MPPASGPSVL ARLLPLLGLL LGSASRAPGK SPPEPPSPQE ILIKVQVYVS GELVPLARAS 70 80 90 100 110 120 VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV 130 140 150 160 170 180 SLYLLPERPA TLILYEDLVH ILLGSPGARS QPLVQFQRRA ARLPVSSTYS QLWASLTPAS 190 200 210 220 230 240 TQQEMRAFPA FLGTEASSSG NGSWLELMPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE 250 260 270 280 290 300 TRALTVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL 310 320 330 340 350 360 VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS 370 380 390 400 410 420 DGNKRDQATS MSQLHLICGG PLEPAPSGDP EAPPPGPLHS AFSSSRDLAS SRDDFFRTKP 430 440 450 460 470 480 RSASRPAAEP SGARGGESAG LKGARSAEGP GGLEPGLEEH RRGPSGAAAF LHEPPSPPPP 490 500 510 520 530 540 FDHYLGHKGA AEGKTPDFLL SQSVDQLARP PSLGQAGQLI FCGSIDHLKD NVYRNVMPTL 550 560 570 580 590 600 VIPAHYVRLG GEAGAAGVGD EPAPPEGTAP GPARAFPQPD PQRPQMPGHS GPGGEGGGGG 610 620 630 640 650 660 GEGWGAGRAA PVSGSVTIPV LFNESTMAQL NGELQALTEK KLLELGVKPH PRAWFVSLDG 670 680 690 700 710 720 RSNSQVRHSY IDLQAGGGAR STDASLDSGV DVHEARPARR RPAREERERA PPAAPPPPPA 730 740 750 760 770 780 PPRLALSEDT EPSSSESRTG LCSPEDNSLT PLLDEVAAPE GRAATVPRGR GRSRGDSSRS 790 800 810 820 SASELRRDSL TSPEDELGAE VGDEAGDKKS PWQRREERPL MVFNVK

References

[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC003043 Genomic DNA. No translation available. CH471178 Genomic DNA. Translation: EAW51598.1.
IPI	IPI00921205.
RefSeq	NP_940877.2.
UniGene	Hs.154001
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A8MVW0.
Genome annotation databases
Ensembl	ENST00000293443; ENSP00000293443; ENSG00000161682; Homo sapiens. [Genome view] ENST00000398346; ENSP00000381388; ENSG00000161682; Homo sapiens. [Genome view]
GeneID	284069.
KEGG	hsa:284069.
Organism-specific databases
CTD	284069.
GeneCards	GC17M039788.
HGNC	HGNC:30480. FAM171A2.
HPA	HPA019770.
GenAtlas	Search...
Phylogenomic databases
OMA	RRDSMTS.
Gene expression databases
Bgee	A8MVW0.
CleanEx	HS_FAM171A2.
Genevestigator	A8MVW0.
Family and domain databases
InterPro	IPR018890. FAM171. [Graphical view]
Pfam	PF10577. UPF0560. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F1712_HUMAN

Accession

Primary (citable) accession number: A8MVW0
Secondary accession number(s): A8MQB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	December 4, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.