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Protein

Putative neutrophil cytosol factor 1C

Gene

NCF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

May be required for activation of the latent NADPH oxidase (necessary for superoxide production).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neutrophil cytosol factor 1C
Short name:
NCF-1C
Alternative name(s):
Putative SH3 and PX domain-containing protein 1C
Gene namesi
Name:NCF1C
Synonyms:SH3PXD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32523. NCF1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Putative neutrophil cytosol factor 1CPRO_0000349368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei321 – 3211PhosphoserineBy similarity
Modified residuei324 – 3241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA8MVU1.
MaxQBiA8MVU1.
PaxDbiA8MVU1.
PRIDEiA8MVU1.

Expressioni

Organism-specific databases

HPAiHPA047836.
HPA052095.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000289473.

Structurei

3D structure databases

ProteinModelPortaliA8MVU1.
SMRiA8MVU1. Positions 1-117, 133-308, 335-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 101101PXPROSITE-ProRule annotationAdd
BLAST
Domaini132 – 19160SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini202 – 26160SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IRR3. Eukaryota.
ENOG410YYZE. LUCA.
HOVERGENiHBG002055.
InParanoidiA8MVU1.
PhylomeDBiA8MVU1.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR015039. NADPH_oxidase_p47Phox_C.
IPR032136. NECFESHC.
IPR001655. P47PHOX.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16621. NECFESHC. 1 hit.
PF08944. p47_phox_C. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00498. P47PHOX.
PR00452. SH3DOMAIN.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MVU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMFLVKWQD LSEKVVYRRF TEIYEFHKTL KEMFPIEAGA INPENRIIPH
60 70 80 90 100
LPAPKWFDGQ RAAENHQGTL TEYCSTLMSL PTKISRCPHL LDFFKVRPDD
110 120 130 140 150
LKLPTDNQTK KPETYLMPKD GKSTATDITG PIILQTYRAI ADYEKTSGSE
160 170 180 190 200
MALSTGDVVE VVEKSESGWW FCQMKAKRGW IPASFLEPLD SPDETEDPEP
210 220 230 240 250
NYAGEPYVAI KAYTAVEGDE VSLLEGEAVE VIHKLLDGWW VIRKDDVTGY
260 270 280 290 300
FPSMYLQKSG QDVSQAQRQI KRGAPPRRSS IRNAHSIHQR SRKRLSQDAY
310 320 330 340 350
RRNSVRFLQQ RRRQARPGPQ SPGSPLEEER QTQRSKPQPA VPPRPSADLI
360
LNRCSESTKR KLASAV
Length:366
Mass (Da):41,851
Last modified:December 4, 2007 - v1
Checksum:i39CFA2C342102DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124781 Genomic DNA. No translation available.
UniGeneiHs.647047.
Hs.648940.
Hs.655201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124781 Genomic DNA. No translation available.
UniGeneiHs.647047.
Hs.648940.
Hs.655201.

3D structure databases

ProteinModelPortaliA8MVU1.
SMRiA8MVU1. Positions 1-117, 133-308, 335-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000289473.

Proteomic databases

EPDiA8MVU1.
MaxQBiA8MVU1.
PaxDbiA8MVU1.
PRIDEiA8MVU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiNCF1C.
HGNCiHGNC:32523. NCF1C.
HPAiHPA047836.
HPA052095.
neXtProtiNX_A8MVU1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRR3. Eukaryota.
ENOG410YYZE. LUCA.
HOVERGENiHBG002055.
InParanoidiA8MVU1.
PhylomeDBiA8MVU1.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR015039. NADPH_oxidase_p47Phox_C.
IPR032136. NECFESHC.
IPR001655. P47PHOX.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16621. NECFESHC. 1 hit.
PF08944. p47_phox_C. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00498. P47PHOX.
PR00452. SH3DOMAIN.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNCF1C_HUMAN
AccessioniPrimary (citable) accession number: A8MVU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: March 16, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.