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Protein
Submitted name:

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta-2Imported
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:6155. ITGB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 10886Sequence analysisPRO_5002723899Add
BLAST

Proteomic databases

PaxDbiA8MVG7.
PRIDEiA8MVG7.

Expressioni

Gene expression databases

BgeeiA8MVG7.
ExpressionAtlasiA8MVG7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303242.

Structurei

3D structure databases

ProteinModelPortaliA8MVG7.
SMRiA8MVG7. Positions 23-49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000015314.

Family and domain databases

InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR016201. Plexin-like_fold.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
SUPFAMiSSF103575. SSF103575. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MVG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLG
60 70 80 90 100
AALGPPAHAT AASSPRRRSR VAPVCPRTEQ GGQAPGGNYL GQAGFFPSPF

WRFSAPLK
Length:108
Mass (Da):11,357
Last modified:December 4, 2007 - v1
Checksum:i212C30A7D3DB4055
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000397846; ENSP00000380944; ENSG00000160255.
UCSCiuc062aum.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA8MVG7.
SMRiA8MVG7. Positions 23-49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303242.

Proteomic databases

PaxDbiA8MVG7.
PRIDEiA8MVG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397846; ENSP00000380944; ENSG00000160255.
UCSCiuc062aum.1. human.

Organism-specific databases

HGNCiHGNC:6155. ITGB2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000015314.

Miscellaneous databases

ChiTaRSiITGB2. human.

Gene expression databases

BgeeiA8MVG7.
ExpressionAtlasiA8MVG7. baseline and differential.

Family and domain databases

InterProiIPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
IPR016201. Plexin-like_fold.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF15. PTHR10082:SF15. 1 hit.
SUPFAMiSSF103575. SSF103575. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Chromosome 21 mapping and sequencing consortium
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA8MVG7_HUMAN
AccessioniPrimary (citable) accession number: A8MVG7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.