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Protein
Submitted name:

Integrin beta-2

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta-2Imported
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:6155. ITGB2.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500272389923 – 108Sequence analysisAdd BLAST86

Proteomic databases

MaxQBiA8MVG7.
PaxDbiA8MVG7.
PeptideAtlasiA8MVG7.
PRIDEiA8MVG7.

Expressioni

Gene expression databases

BgeeiENSG00000160255.
ExpressionAtlasiA8MVG7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA8MVG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 49PSI_integrinInterPro annotationAdd BLAST27

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000015314.

Family and domain databases

InterProiView protein in InterPro
IPR033760. Integrin_beta_N.
IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2.
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF47. PTHR10082:SF47. 1 hit.
PfamiView protein in Pfam
PF17205. PSI_integrin. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MVG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLG
60 70 80 90 100
AALGPPAHAT AASSPRRRSR VAPVCPRTEQ GGQAPGGNYL GQAGFFPSPF

WRFSAPLK
Length:108
Mass (Da):11,357
Last modified:December 4, 2007 - v1
Checksum:i212C30A7D3DB4055
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA. No translation available.
AL844907 Genomic DNA. No translation available.
AL844908 Genomic DNA. No translation available.
KC877928 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000397846; ENSP00000380944; ENSG00000160255.
UCSCiuc062aum.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8MVG7_HUMAN
AccessioniPrimary (citable) accession number: A8MVG7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 5, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported