ID   KRA96_HUMAN             Reviewed;         160 AA.
AC   A8MVA2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   RecName: Full=Keratin-associated protein 9-6 {ECO:0000305};
DE   AltName: Full=Keratin-associated protein 9-like 2 {ECO:0000312|HGNC:HGNC:18914};
GN   Name=KRTAP9-6 {ECO:0000312|HGNC:HGNC:18914};
GN   Synonyms=KAP9.6, KRTAP9.6, KRTAP9L2 {ECO:0000312|HGNC:HGNC:18914};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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DR   EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59286.1; -.
DR   RefSeq; NP_001264260.1; NM_001277331.1.
DR   AlphaFoldDB; A8MVA2; -.
DR   STRING; 9606.ENSP00000375150; -.
DR   BioMuta; KRTAP9-6; -.
DR   MassIVE; A8MVA2; -.
DR   PaxDb; 9606-ENSP00000375150; -.
DR   PeptideAtlas; A8MVA2; -.
DR   DNASU; 100507608; -.
DR   Ensembl; ENST00000391355.2; ENSP00000375150.1; ENSG00000212659.2.
DR   Ensembl; ENST00000576511.1; ENSP00000460691.1; ENSG00000263263.1.
DR   GeneID; 100507608; -.
DR   KEGG; hsa:100507608; -.
DR   MANE-Select; ENST00000391355.2; ENSP00000375150.1; NM_001277331.1; NP_001264260.1.
DR   UCSC; uc031rag.2; human.
DR   AGR; HGNC:18914; -.
DR   CTD; 100507608; -.
DR   GeneCards; KRTAP9-6; -.
DR   HGNC; HGNC:18914; KRTAP9-6.
DR   HPA; ENSG00000212659; Tissue enriched (skin).
DR   neXtProt; NX_A8MVA2; -.
DR   VEuPathDB; HostDB:ENSG00000212659; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000156135; -.
DR   HOGENOM; CLU_113141_2_0_1; -.
DR   InParanoid; A8MVA2; -.
DR   OMA; SCQYPSC; -.
DR   TreeFam; TF351356; -.
DR   PathwayCommons; A8MVA2; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   BioGRID-ORCS; 100507608; 119 hits in 1048 CRISPR screens.
DR   Pharos; A8MVA2; Tdark.
DR   PRO; PR:A8MVA2; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A8MVA2; Protein.
DR   Bgee; ENSG00000212659; Expressed in skin of abdomen and 2 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; KERATIN ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23262:SF252; KERATIN-ASSOCIATED PROTEIN 9-6; 1.
DR   Pfam; PF13885; Keratin_B2_2; 2.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..160
FT                   /note="Keratin-associated protein 9-6"
FT                   /id="PRO_0000332260"
FT   REPEAT          4..8
FT                   /note="1"
FT   REPEAT          13..17
FT                   /note="2"
FT   REPEAT          18..22
FT                   /note="3"
FT   REPEAT          37..41
FT                   /note="4"
FT   REPEAT          42..46
FT                   /note="5"
FT   REPEAT          47..51
FT                   /note="6"
FT   REPEAT          56..60
FT                   /note="7"
FT   REPEAT          61..65
FT                   /note="8"
FT   REPEAT          66..70
FT                   /note="9"
FT   REPEAT          75..79
FT                   /note="10"
FT   REPEAT          80..84
FT                   /note="11"
FT   REPEAT          90..94
FT                   /note="12"
FT   REPEAT          95..99
FT                   /note="13"
FT   REPEAT          140..144
FT                   /note="14"
FT   REPEAT          149..153
FT                   /note="15"
FT   REPEAT          154..158
FT                   /note="16"
FT   REGION          4..158
FT                   /note="16 X 5 AA repeats of C-C-[GSVRQ]-[QTSPHN]-[TPSGYC]"
FT   VARIANT         86
FT                   /note="Y -> C (in dbSNP:rs12938692)"
FT                   /id="VAR_042997"
SQ   SEQUENCE   160 AA;  16800 MW;  CB6254D9E7B2CA15 CRC64;
     MTHCCSPGCQ PTCCRTTCCR TTCWQPTIVT TCSSTPCCQP SCCVSSCCQP YCHPTCCQNT
     CCRTTCCQPT CVTSCCQPSC CSTPCYQPIC CGSSCCGQTS CGSSCGQSSS CAPVYCRRTC
     YHPTTVCLPG CLNQSCGSSC CQPCYCPACC VSSCCQHSCC
//