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A8MVA2 (KRA96_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 9-6
Gene names
Name:KRTAP9-6
Synonyms:KAP9.6, KRTAP9.6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 9 family.

Ontologies

Keywords
   Cellular componentKeratin
   Coding sequence diversityPolymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 160160Keratin-associated protein 9-6
PRO_0000332260

Regions

Repeat4 – 851
Repeat13 – 1752
Repeat18 – 2253
Repeat37 – 4154
Repeat42 – 4655
Repeat47 – 5156
Repeat56 – 6057
Repeat61 – 6558
Repeat66 – 7059
Repeat75 – 79510
Repeat80 – 84511
Repeat90 – 94512
Repeat95 – 99513
Repeat140 – 144514
Repeat149 – 153515
Repeat154 – 158516
Region4 – 15815516 X 5 AA repeats of C-C-[GSVRQ]-[QTSPHN]-[TPSGYC]

Natural variations

Natural variant861Y → C.
Corresponds to variant rs12938692 [ dbSNP | Ensembl ].
VAR_042997

Sequences

Sequence LengthMass (Da)Tools
A8MVA2 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: CB6254D9E7B2CA15

FASTA16016,800
        10         20         30         40         50         60 
MTHCCSPGCQ PTCCRTTCCR TTCWQPTIVT TCSSTPCCQP SCCVSSCCQP YCHPTCCQNT 

        70         80         90        100        110        120 
CCRTTCCQPT CVTSCCQPSC CSTPCYQPIC CGSSCCGQTS CGSSCGQSSS CAPVYCRRTC 

       130        140        150        160 
YHPTTVCLPG CLNQSCGSSC CQPCYCPACC VSSCCQHSCC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006070 Genomic DNA. No translation available.
RefSeqNP_001264260.1. NM_001277331.1.

3D structure databases

ProteinModelPortalA8MVA2.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA8MVA2.
PRIDEA8MVA2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391355; ENSP00000375150; ENSG00000212659.
ENST00000576511; ENSP00000460691; ENSG00000263263.
GeneID100507608.
KEGGhsa:100507608.
UCSCuc031rag.1. human.

Organism-specific databases

CTD100507608.
GeneCardsGC17P039421.
HGNCHGNC:18914. KRTAP9-6.
neXtProtNX_A8MVA2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279023.
HOGENOMHOG000234030.
InParanoidA8MVA2.
OMACYCPACC.
TreeFamTF351356.

Gene expression databases

GenevestigatorA8MVA2.

Family and domain databases

InterProIPR002494. Keratin-assoc.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
ProtoNetSearch...

Other

NextBio34054786.
PROA8MVA2.

Entry information

Entry nameKRA96_HUMAN
AccessionPrimary (citable) accession number: A8MVA2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM