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A8MVA2

- KRA96_HUMAN

UniProt

A8MVA2 - KRA96_HUMAN

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Protein
Keratin-associated protein 9-6
Gene
KRTAP9-6, KAP9.6, KRTAP9.6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-6
Gene namesi
Synonyms:KAP9.6, KRTAP9.6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18914. KRTAP9-6.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Keratin-associated protein 9-6
PRO_0000332260Add
BLAST

Proteomic databases

PaxDbiA8MVA2.
PRIDEiA8MVA2.

Expressioni

Gene expression databases

GenevestigatoriA8MVA2.

Interactioni

Subunit structurei

Interacts with hair keratins By similarity.

Structurei

3D structure databases

ProteinModelPortaliA8MVA2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 851
Repeati13 – 1752
Repeati18 – 2253
Repeati37 – 4154
Repeati42 – 4655
Repeati47 – 5156
Repeati56 – 6057
Repeati61 – 6558
Repeati66 – 7059
Repeati75 – 79510
Repeati80 – 84511
Repeati90 – 94512
Repeati95 – 99513
Repeati140 – 144514
Repeati149 – 153515
Repeati154 – 158516

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 15815516 X 5 AA repeats of C-C-[GSVRQ]-[QTSPHN]-[TPSGYC]
Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 9 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG279023.
HOGENOMiHOG000234030.
InParanoidiA8MVA2.
OMAiCKPCCSP.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MVA2-1 [UniParc]FASTAAdd to Basket

« Hide

MTHCCSPGCQ PTCCRTTCCR TTCWQPTIVT TCSSTPCCQP SCCVSSCCQP    50
YCHPTCCQNT CCRTTCCQPT CVTSCCQPSC CSTPCYQPIC CGSSCCGQTS 100
CGSSCGQSSS CAPVYCRRTC YHPTTVCLPG CLNQSCGSSC CQPCYCPACC 150
VSSCCQHSCC 160
Length:160
Mass (Da):16,800
Last modified:December 4, 2007 - v1
Checksum:iCB6254D9E7B2CA15
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861Y → C.
Corresponds to variant rs12938692 [ dbSNP | Ensembl ].
VAR_042997

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS59286.1.
RefSeqiNP_001264260.1. NM_001277331.1.

Genome annotation databases

EnsembliENST00000391355; ENSP00000375150; ENSG00000212659.
ENST00000576511; ENSP00000460691; ENSG00000263263.
GeneIDi100507608.
KEGGihsa:100507608.
UCSCiuc031rag.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSi CCDS59286.1.
RefSeqi NP_001264260.1. NM_001277331.1.

3D structure databases

ProteinModelPortali A8MVA2.
ModBasei Search...

Proteomic databases

PaxDbi A8MVA2.
PRIDEi A8MVA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391355 ; ENSP00000375150 ; ENSG00000212659 .
ENST00000576511 ; ENSP00000460691 ; ENSG00000263263 .
GeneIDi 100507608.
KEGGi hsa:100507608.
UCSCi uc031rag.1. human.

Organism-specific databases

CTDi 100507608.
GeneCardsi GC17P039421.
HGNCi HGNC:18914. KRTAP9-6.
neXtProti NX_A8MVA2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279023.
HOGENOMi HOG000234030.
InParanoidi A8MVA2.
OMAi CKPCCSP.
TreeFami TF351356.

Miscellaneous databases

NextBioi 34054786.
PROi A8MVA2.

Gene expression databases

Genevestigatori A8MVA2.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
Pfami PF13885. Keratin_B2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKRA96_HUMAN
AccessioniPrimary (citable) accession number: A8MVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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