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A8MVA2

- KRA96_HUMAN

UniProt

A8MVA2 - KRA96_HUMAN

Protein

Keratin-associated protein 9-6

Gene

KRTAP9-6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 9-6
    Gene namesi
    Name:KRTAP9-6
    Synonyms:KAP9.6, KRTAP9.6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18914. KRTAP9-6.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 160160Keratin-associated protein 9-6PRO_0000332260Add
    BLAST

    Proteomic databases

    PaxDbiA8MVA2.
    PRIDEiA8MVA2.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MVA2.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA8MVA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 851
    Repeati13 – 1752
    Repeati18 – 2253
    Repeati37 – 4154
    Repeati42 – 4655
    Repeati47 – 5156
    Repeati56 – 6057
    Repeati61 – 6558
    Repeati66 – 7059
    Repeati75 – 79510
    Repeati80 – 84511
    Repeati90 – 94512
    Repeati95 – 99513
    Repeati140 – 144514
    Repeati149 – 153515
    Repeati154 – 158516

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 15815516 X 5 AA repeats of C-C-[GSVRQ]-[QTSPHN]-[TPSGYC]Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 9 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG279023.
    HOGENOMiHOG000234030.
    InParanoidiA8MVA2.
    OMAiCKPCCSP.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF13885. Keratin_B2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MVA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHCCSPGCQ PTCCRTTCCR TTCWQPTIVT TCSSTPCCQP SCCVSSCCQP    50
    YCHPTCCQNT CCRTTCCQPT CVTSCCQPSC CSTPCYQPIC CGSSCCGQTS 100
    CGSSCGQSSS CAPVYCRRTC YHPTTVCLPG CLNQSCGSSC CQPCYCPACC 150
    VSSCCQHSCC 160
    Length:160
    Mass (Da):16,800
    Last modified:December 4, 2007 - v1
    Checksum:iCB6254D9E7B2CA15
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861Y → C.
    Corresponds to variant rs12938692 [ dbSNP | Ensembl ].
    VAR_042997

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSiCCDS59286.1.
    RefSeqiNP_001264260.1. NM_001277331.1.

    Genome annotation databases

    EnsembliENST00000391355; ENSP00000375150; ENSG00000212659.
    ENST00000576511; ENSP00000460691; ENSG00000263263.
    GeneIDi100507608.
    KEGGihsa:100507608.
    UCSCiuc031rag.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSi CCDS59286.1.
    RefSeqi NP_001264260.1. NM_001277331.1.

    3D structure databases

    ProteinModelPortali A8MVA2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A8MVA2.
    PRIDEi A8MVA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391355 ; ENSP00000375150 ; ENSG00000212659 .
    ENST00000576511 ; ENSP00000460691 ; ENSG00000263263 .
    GeneIDi 100507608.
    KEGGi hsa:100507608.
    UCSCi uc031rag.1. human.

    Organism-specific databases

    CTDi 100507608.
    GeneCardsi GC17P039421.
    HGNCi HGNC:18914. KRTAP9-6.
    neXtProti NX_A8MVA2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279023.
    HOGENOMi HOG000234030.
    InParanoidi A8MVA2.
    OMAi CKPCCSP.
    TreeFami TF351356.

    Miscellaneous databases

    NextBioi 34054786.
    PROi A8MVA2.

    Gene expression databases

    Genevestigatori A8MVA2.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF13885. Keratin_B2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKRA96_HUMAN
    AccessioniPrimary (citable) accession number: A8MVA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3