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A8MV65

- VGLL3_HUMAN

UniProt

A8MV65 - VGLL3_HUMAN

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Protein
Transcription cofactor vestigial-like protein 3
Gene
VGLL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a specific coactivator for the mammalian TEFs By similarity.By similarity

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 3
Short name:
Vgl-3
Gene namesi
Name:VGLL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24327. VGLL3.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Transcription cofactor vestigial-like protein 3
PRO_0000324661Add
BLAST

Proteomic databases

MaxQBiA8MV65.
PaxDbiA8MV65.
PRIDEiA8MV65.

PTM databases

PhosphoSiteiA8MV65.

Expressioni

Tissue specificityi

Enriched in placenta.1 Publication

Gene expression databases

BgeeiA8MV65.
CleanExiHS_VGLL3.
GenevestigatoriA8MV65.

Organism-specific databases

HPAiHPA054983.

Interactioni

Protein-protein interaction databases

BioGridi132991. 1 interaction.
STRINGi9606.ENSP00000381436.

Structurei

3D structure databases

ProteinModelPortaliA8MV65.
SMRiA8MV65. Positions 79-110.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 24828His-rich
Add
BLAST

Sequence similaritiesi

Belongs to the vestigial family.

Phylogenomic databases

eggNOGiNOG39971.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiA8MV65.
OMAiGHSLHQT.
OrthoDBiEOG7K9K52.
PhylomeDBiA8MV65.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: A8MV65-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK    50
MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS 100
VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF 150
WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP 200
PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP 250
AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG 300
TVDIVPSVGF DTGLQHQDKS KESPWY 326

Note: Gene prediction based on EST data.

Length:326
Mass (Da):36,009
Last modified:December 4, 2007 - v1
Checksum:i08D015C2A4297FE8
GO
Isoform 21 Publication (identifier: A8MV65-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS

Note: No experimental confirmation available.

Show »
Length:320
Mass (Da):35,171
Checksum:i2FFF6081DD363630
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei314 – 32613LQHQD…ESPWY → WSAMARS in isoform 2. 1 Publication
VSP_052713Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108709 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68870.1.
CH471110 Genomic DNA. Translation: EAW68871.1.
BC094780 mRNA. Translation: AAH94780.1.
CCDSiCCDS43110.1. [A8MV65-1]
RefSeqiNP_057290.2. NM_016206.2. [A8MV65-1]
XP_005264809.1. XM_005264752.2. [A8MV65-2]
UniGeneiHs.606507.
Hs.744116.

Genome annotation databases

EnsembliENST00000383698; ENSP00000373199; ENSG00000206538. [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538. [A8MV65-1]
GeneIDi389136.
KEGGihsa:389136.
UCSCiuc003dqn.3. human. [A8MV65-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC108709 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68870.1 .
CH471110 Genomic DNA. Translation: EAW68871.1 .
BC094780 mRNA. Translation: AAH94780.1 .
CCDSi CCDS43110.1. [A8MV65-1 ]
RefSeqi NP_057290.2. NM_016206.2. [A8MV65-1 ]
XP_005264809.1. XM_005264752.2. [A8MV65-2 ]
UniGenei Hs.606507.
Hs.744116.

3D structure databases

ProteinModelPortali A8MV65.
SMRi A8MV65. Positions 79-110.
ModBasei Search...

Protein-protein interaction databases

BioGridi 132991. 1 interaction.
STRINGi 9606.ENSP00000381436.

PTM databases

PhosphoSitei A8MV65.

Proteomic databases

MaxQBi A8MV65.
PaxDbi A8MV65.
PRIDEi A8MV65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383698 ; ENSP00000373199 ; ENSG00000206538 . [A8MV65-2 ]
ENST00000398399 ; ENSP00000381436 ; ENSG00000206538 . [A8MV65-1 ]
GeneIDi 389136.
KEGGi hsa:389136.
UCSCi uc003dqn.3. human. [A8MV65-1 ]

Organism-specific databases

CTDi 389136.
GeneCardsi GC03M087071.
H-InvDB HIX0003478.
HGNCi HGNC:24327. VGLL3.
HPAi HPA054983.
MIMi 609980. gene.
neXtProti NX_A8MV65.
PharmGKBi PA142670628.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39971.
HOGENOMi HOG000143402.
HOVERGENi HBG057778.
InParanoidi A8MV65.
OMAi GHSLHQT.
OrthoDBi EOG7K9K52.
PhylomeDBi A8MV65.
TreeFami TF326340.

Miscellaneous databases

GenomeRNAii 389136.
NextBioi 102627.
PROi A8MV65.
SOURCEi Search...

Gene expression databases

Bgeei A8MV65.
CleanExi HS_VGLL3.
Genevestigatori A8MV65.

Family and domain databases

InterProi IPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view ]
PANTHERi PTHR15950. PTHR15950. 1 hit.
Pfami PF07545. Vg_Tdu. 1 hit.
[Graphical view ]
SMARTi SM00711. TDU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
    Maeda T., Chapman D.L., Stewart A.F.R.
    J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVGLL3_HUMAN
AccessioniPrimary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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