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Protein

Transcription cofactor vestigial-like protein 3

Gene

VGLL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 3
Short name:
Vgl-3
Gene namesi
Name:VGLL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24327. VGLL3.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670628.

Polymorphism and mutation databases

BioMutaiVGLL3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Transcription cofactor vestigial-like protein 3PRO_0000324661Add
BLAST

Proteomic databases

MaxQBiA8MV65.
PaxDbiA8MV65.
PRIDEiA8MV65.

PTM databases

PhosphoSiteiA8MV65.

Expressioni

Tissue specificityi

Enriched in placenta.1 Publication

Gene expression databases

BgeeiA8MV65.
CleanExiHS_VGLL3.
ExpressionAtlasiA8MV65. baseline and differential.
GenevestigatoriA8MV65.

Organism-specific databases

HPAiHPA054983.

Interactioni

Protein-protein interaction databases

BioGridi132991. 1 interaction.
STRINGi9606.ENSP00000381436.

Structurei

3D structure databases

ProteinModelPortaliA8MV65.
SMRiA8MV65. Positions 79-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 24828His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the vestigial family.Sequence Analysis

Phylogenomic databases

eggNOGiNOG39971.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiA8MV65.
OMAiGHSLHQT.
OrthoDBiEOG7K9K52.
PhylomeDBiA8MV65.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MV65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK
60 70 80 90 100
MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS
110 120 130 140 150
VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF
160 170 180 190 200
WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP
210 220 230 240 250
PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP
260 270 280 290 300
AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG
310 320
TVDIVPSVGF DTGLQHQDKS KESPWY

Note: Gene prediction based on EST data.Curated

Length:326
Mass (Da):36,009
Last modified:December 4, 2007 - v1
Checksum:i08D015C2A4297FE8
GO
Isoform 21 Publication (identifier: A8MV65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS

Note: No experimental confirmation available.Curated

Show »
Length:320
Mass (Da):35,171
Checksum:i2FFF6081DD363630
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei314 – 32613LQHQD…ESPWY → WSAMARS in isoform 2. 1 PublicationVSP_052713Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108709 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68870.1.
CH471110 Genomic DNA. Translation: EAW68871.1.
BC094780 mRNA. Translation: AAH94780.1.
CCDSiCCDS43110.1. [A8MV65-1]
RefSeqiNP_057290.2. NM_016206.2. [A8MV65-1]
XP_005264809.1. XM_005264752.3. [A8MV65-2]
UniGeneiHs.606507.
Hs.744116.

Genome annotation databases

EnsembliENST00000383698; ENSP00000373199; ENSG00000206538. [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538. [A8MV65-1]
GeneIDi389136.
KEGGihsa:389136.
UCSCiuc003dqn.3. human. [A8MV65-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108709 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68870.1.
CH471110 Genomic DNA. Translation: EAW68871.1.
BC094780 mRNA. Translation: AAH94780.1.
CCDSiCCDS43110.1. [A8MV65-1]
RefSeqiNP_057290.2. NM_016206.2. [A8MV65-1]
XP_005264809.1. XM_005264752.3. [A8MV65-2]
UniGeneiHs.606507.
Hs.744116.

3D structure databases

ProteinModelPortaliA8MV65.
SMRiA8MV65. Positions 79-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132991. 1 interaction.
STRINGi9606.ENSP00000381436.

PTM databases

PhosphoSiteiA8MV65.

Polymorphism and mutation databases

BioMutaiVGLL3.

Proteomic databases

MaxQBiA8MV65.
PaxDbiA8MV65.
PRIDEiA8MV65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383698; ENSP00000373199; ENSG00000206538. [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538. [A8MV65-1]
GeneIDi389136.
KEGGihsa:389136.
UCSCiuc003dqn.3. human. [A8MV65-1]

Organism-specific databases

CTDi389136.
GeneCardsiGC03M087071.
H-InvDBHIX0003478.
HGNCiHGNC:24327. VGLL3.
HPAiHPA054983.
MIMi609980. gene.
neXtProtiNX_A8MV65.
PharmGKBiPA142670628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39971.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiA8MV65.
OMAiGHSLHQT.
OrthoDBiEOG7K9K52.
PhylomeDBiA8MV65.
TreeFamiTF326340.

Miscellaneous databases

ChiTaRSiVGLL3. human.
GenomeRNAii389136.
NextBioi102627.
PROiA8MV65.
SOURCEiSearch...

Gene expression databases

BgeeiA8MV65.
CleanExiHS_VGLL3.
ExpressionAtlasiA8MV65. baseline and differential.
GenevestigatoriA8MV65.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: PlacentaImported.
  4. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
    Maeda T., Chapman D.L., Stewart A.F.R.
    J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVGLL3_HUMAN
AccessioniPrimary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: May 27, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.