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Protein

Transcription cofactor vestigial-like protein 3

Gene

VGLL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 3
Short name:
Vgl-3
Gene namesi
Name:VGLL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000206538.7
HGNCiHGNC:24327 VGLL3
MIMi609980 gene
neXtProtiNX_A8MV65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi389136
OpenTargetsiENSG00000206538
PharmGKBiPA142670628

Polymorphism and mutation databases

BioMutaiVGLL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246611 – 326Transcription cofactor vestigial-like protein 3Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiA8MV65
PaxDbiA8MV65
PRIDEiA8MV65

PTM databases

iPTMnetiA8MV65
PhosphoSitePlusiA8MV65

Expressioni

Tissue specificityi

Enriched in placenta.1 Publication

Gene expression databases

BgeeiENSG00000206538
CleanExiHS_VGLL3
ExpressionAtlasiA8MV65 baseline and differential
GenevisibleiA8MV65 HS

Organism-specific databases

HPAiHPA054983

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi132991, 1 interactor
IntActiA8MV65, 68 interactors
STRINGi9606.ENSP00000381436

Structurei

3D structure databases

ProteinModelPortaliA8MV65
SMRiA8MV65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 248His-richSequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the vestigial family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410II4C Eukaryota
ENOG4111HDH LUCA
GeneTreeiENSGT00530000063353
HOGENOMiHOG000143402
HOVERGENiHBG057778
InParanoidiA8MV65
OMAiQRSSFPT
OrthoDBiEOG091G0GKN
PhylomeDBiA8MV65
TreeFamiTF326340

Family and domain databases

InterProiView protein in InterPro
IPR006627 TDU_repeat
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 1 hit
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit
SMARTiView protein in SMART
SM00711 TDU, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MV65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK
60 70 80 90 100
MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS
110 120 130 140 150
VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF
160 170 180 190 200
WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP
210 220 230 240 250
PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP
260 270 280 290 300
AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG
310 320
TVDIVPSVGF DTGLQHQDKS KESPWY
Note: Gene prediction based on EST data.Curated
Length:326
Mass (Da):36,009
Last modified:December 4, 2007 - v1
Checksum:i08D015C2A4297FE8
GO
Isoform 21 Publication (identifier: A8MV65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS

Note: No experimental confirmation available.Curated
Show »
Length:320
Mass (Da):35,171
Checksum:i2FFF6081DD363630
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052713314 – 326LQHQD…ESPWY → WSAMARS in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108709 Genomic DNA No translation available.
CH471110 Genomic DNA Translation: EAW68870.1
CH471110 Genomic DNA Translation: EAW68871.1
BC094780 mRNA Translation: AAH94780.1
CCDSiCCDS43110.1 [A8MV65-1]
CCDS82807.1 [A8MV65-2]
RefSeqiNP_001307422.1, NM_001320493.1 [A8MV65-2]
NP_057290.2, NM_016206.3 [A8MV65-1]
UniGeneiHs.606507
Hs.744116

Genome annotation databases

EnsembliENST00000383698; ENSP00000373199; ENSG00000206538 [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538 [A8MV65-1]
GeneIDi389136
KEGGihsa:389136
UCSCiuc003dqn.4 human [A8MV65-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVGLL3_HUMAN
AccessioniPrimary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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