A8MV65 (VGLL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription cofactor vestigial-like protein 3
Short name=Vgl-3

Gene names

Name:

VGLL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a specific coactivator for the mammalian TEFs By similarity. UniProtKB Q8N8G2
Subcellular location	Nucleus By similarity UniProtKB Q8N8G2.
Tissue specificity	Enriched in placenta. Ref.4
Sequence similarities	Belongs to the vestigial family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: A8MV65-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 Ref.3 (identifier: A8MV65-2)

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Transcription cofactor vestigial-like protein 3		PRO_0000324661
Regions
	Compositional bias	221 – 248	28	His-rich
Natural variations
	Alternative sequence	314 – 326	13	LQHQD…ESPWY → WSAMARS in isoform 2. Ref.3		VSP_052713

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 08D015C2A4297FE8	FASTA	326	36,009
	10 20 30 40 50 60 MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK MQDSLEVTLP 70 80 90 100 110 120 SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS VVDEHFSRAL GQAITLHPES 130 140 150 160 170 180 AISKSKMGLT PLWRDSSALS SQRNSFPTSF WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS 190 200 210 220 230 240 AADPSPWPGH NLHQTGPAPP PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH 250 260 270 280 290 300 RHHHHHHHPP AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG 310 320 TVDIVPSVGF DTGLQHQDKS KESPWY
	Isoform 2 [UniParc]. Checksum: 2FFF6081DD363630	FASTA	320	35,171
	10 20 30 40 50 60 MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK MQDSLEVTLP 70 80 90 100 110 120 SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS VVDEHFSRAL GQAITLHPES 130 140 150 160 170 180 AISKSKMGLT PLWRDSSALS SQRNSFPTSF WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS 190 200 210 220 230 240 AADPSPWPGH NLHQTGPAPP PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH 250 260 270 280 290 300 RHHHHHHHPP AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG 310 320 TVDIVPSVGF DTGWSAMARS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation." Maeda T., Chapman D.L., Stewart A.F.R. J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC108709 Genomic DNA. No translation available. CH471110 Genomic DNA. Translation: EAW68870.1. CH471110 Genomic DNA. Translation: EAW68871.1. BC094780 mRNA. Translation: AAH94780.1.
IPI	IPI00514518. IPI00874001.
RefSeq	NP_057290.2. NM_016206.2.
UniGene	Hs.435013.
3D structure databases
ProteinModelPortal	A8MV65.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381436.
PTM databases
PhosphoSite	A8MV65.
Proteomic databases
PaxDb	A8MV65.
PRIDE	A8MV65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383698; ENSP00000373199; ENSG00000206538. ENST00000398399; ENSP00000381436; ENSG00000206538.
GeneID	389136.
KEGG	hsa:389136.
UCSC	uc003dqn.3. human.
Organism-specific databases
CTD	389136.
GeneCards	GC03M087071.
H-InvDB	HIX0003478.
HGNC	HGNC:24327. VGLL3.
MIM	609980. gene.
neXtProt	NX_A8MV65.
PharmGKB	PA142670628.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39971.
HOGENOM	HOG000143402.
HOVERGEN	HBG057778.
InParanoid	A8MV65.
OMA	YLRHHHP.
OrthoDB	EOG4P5K9N.
Gene expression databases
Bgee	A8MV65.
CleanEx	HS_VGLL3.
Genevestigator	A8MV65.
Family and domain databases
InterPro	IPR006627. TDU_repeat. IPR011520. Vg_Tdu. [Graphical view]
PANTHER	PTHR15950. PTHR15950. 1 hit.
Pfam	PF07545. Vg_Tdu. 1 hit. [Graphical view]
SMART	SM00711. TDU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389136.
NextBio	102627.
SOURCE	Search...

Entry information

Entry name

VGLL3_HUMAN

Accession

Primary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	December 4, 2007
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.