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A8MV65

- VGLL3_HUMAN

UniProt

A8MV65 - VGLL3_HUMAN

Protein

Transcription cofactor vestigial-like protein 3

Gene

VGLL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    May act as a specific coactivator for the mammalian TEFs.By similarity

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription cofactor vestigial-like protein 3
    Short name:
    Vgl-3
    Gene namesi
    Name:VGLL3Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24327. VGLL3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670628.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Transcription cofactor vestigial-like protein 3PRO_0000324661Add
    BLAST

    Proteomic databases

    MaxQBiA8MV65.
    PaxDbiA8MV65.
    PRIDEiA8MV65.

    PTM databases

    PhosphoSiteiA8MV65.

    Expressioni

    Tissue specificityi

    Enriched in placenta.1 Publication

    Gene expression databases

    BgeeiA8MV65.
    CleanExiHS_VGLL3.
    GenevestigatoriA8MV65.

    Organism-specific databases

    HPAiHPA054983.

    Interactioni

    Protein-protein interaction databases

    BioGridi132991. 1 interaction.
    STRINGi9606.ENSP00000381436.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MV65.
    SMRiA8MV65. Positions 79-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 24828His-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the vestigial family.Sequence Analysis

    Phylogenomic databases

    eggNOGiNOG39971.
    HOGENOMiHOG000143402.
    HOVERGENiHBG057778.
    InParanoidiA8MV65.
    OMAiGHSLHQT.
    OrthoDBiEOG7K9K52.
    PhylomeDBiA8MV65.
    TreeFamiTF326340.

    Family and domain databases

    InterProiIPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view]
    PANTHERiPTHR15950. PTHR15950. 1 hit.
    PfamiPF07545. Vg_Tdu. 1 hit.
    [Graphical view]
    SMARTiSM00711. TDU. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A8MV65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK    50
    MQDSLEVTLP SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS 100
    VVDEHFSRAL GQAITLHPES AISKSKMGLT PLWRDSSALS SQRNSFPTSF 150
    WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS AADPSPWPGH NLHQTGPAPP 200
    PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH RHHHHHHHPP 250
    AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG 300
    TVDIVPSVGF DTGLQHQDKS KESPWY 326

    Note: Gene prediction based on EST data.Curated

    Length:326
    Mass (Da):36,009
    Last modified:December 4, 2007 - v1
    Checksum:i08D015C2A4297FE8
    GO
    Isoform 21 Publication (identifier: A8MV65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         314-326: LQHQDKSKESPWY → WSAMARS

    Note: No experimental confirmation available.Curated

    Show »
    Length:320
    Mass (Da):35,171
    Checksum:i2FFF6081DD363630
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei314 – 32613LQHQD…ESPWY → WSAMARS in isoform 2. 1 PublicationVSP_052713Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108709 Genomic DNA. No translation available.
    CH471110 Genomic DNA. Translation: EAW68870.1.
    CH471110 Genomic DNA. Translation: EAW68871.1.
    BC094780 mRNA. Translation: AAH94780.1.
    CCDSiCCDS43110.1. [A8MV65-1]
    RefSeqiNP_057290.2. NM_016206.2. [A8MV65-1]
    XP_005264809.1. XM_005264752.2. [A8MV65-2]
    UniGeneiHs.606507.
    Hs.744116.

    Genome annotation databases

    EnsembliENST00000383698; ENSP00000373199; ENSG00000206538. [A8MV65-2]
    ENST00000398399; ENSP00000381436; ENSG00000206538. [A8MV65-1]
    GeneIDi389136.
    KEGGihsa:389136.
    UCSCiuc003dqn.3. human. [A8MV65-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108709 Genomic DNA. No translation available.
    CH471110 Genomic DNA. Translation: EAW68870.1 .
    CH471110 Genomic DNA. Translation: EAW68871.1 .
    BC094780 mRNA. Translation: AAH94780.1 .
    CCDSi CCDS43110.1. [A8MV65-1 ]
    RefSeqi NP_057290.2. NM_016206.2. [A8MV65-1 ]
    XP_005264809.1. XM_005264752.2. [A8MV65-2 ]
    UniGenei Hs.606507.
    Hs.744116.

    3D structure databases

    ProteinModelPortali A8MV65.
    SMRi A8MV65. Positions 79-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132991. 1 interaction.
    STRINGi 9606.ENSP00000381436.

    PTM databases

    PhosphoSitei A8MV65.

    Proteomic databases

    MaxQBi A8MV65.
    PaxDbi A8MV65.
    PRIDEi A8MV65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383698 ; ENSP00000373199 ; ENSG00000206538 . [A8MV65-2 ]
    ENST00000398399 ; ENSP00000381436 ; ENSG00000206538 . [A8MV65-1 ]
    GeneIDi 389136.
    KEGGi hsa:389136.
    UCSCi uc003dqn.3. human. [A8MV65-1 ]

    Organism-specific databases

    CTDi 389136.
    GeneCardsi GC03M087071.
    H-InvDB HIX0003478.
    HGNCi HGNC:24327. VGLL3.
    HPAi HPA054983.
    MIMi 609980. gene.
    neXtProti NX_A8MV65.
    PharmGKBi PA142670628.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39971.
    HOGENOMi HOG000143402.
    HOVERGENi HBG057778.
    InParanoidi A8MV65.
    OMAi GHSLHQT.
    OrthoDBi EOG7K9K52.
    PhylomeDBi A8MV65.
    TreeFami TF326340.

    Miscellaneous databases

    GenomeRNAii 389136.
    NextBioi 102627.
    PROi A8MV65.
    SOURCEi Search...

    Gene expression databases

    Bgeei A8MV65.
    CleanExi HS_VGLL3.
    Genevestigatori A8MV65.

    Family and domain databases

    InterProi IPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view ]
    PANTHERi PTHR15950. PTHR15950. 1 hit.
    Pfami PF07545. Vg_Tdu. 1 hit.
    [Graphical view ]
    SMARTi SM00711. TDU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: PlacentaImported.
    4. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
      Maeda T., Chapman D.L., Stewart A.F.R.
      J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiVGLL3_HUMAN
    AccessioniPrimary (citable) accession number: A8MV65
    Secondary accession number(s): D3DU37, Q504T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3