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A8MV65 (VGLL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription cofactor vestigial-like protein 3

Short name=Vgl-3
Gene names
Name:VGLL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a specific coactivator for the mammalian TEFs By similarity. UniProtKB Q8N8G2

Subcellular location

Nucleus By similarity UniProtKB Q8N8G2.

Tissue specificity

Enriched in placenta. Ref.4

Sequence similarities

Belongs to the vestigial family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: A8MV65-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene prediction based on EST data.
Isoform 2 Ref.3 (identifier: A8MV65-2)

The sequence of this isoform differs from the canonical sequence as follows:
     314-326: LQHQDKSKESPWY → WSAMARS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Transcription cofactor vestigial-like protein 3
PRO_0000324661

Regions

Compositional bias221 – 24828His-rich

Natural variations

Alternative sequence314 – 32613LQHQD…ESPWY → WSAMARS in isoform 2. Ref.3
VSP_052713

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 08D015C2A4297FE8

FASTA32636,009
        10         20         30         40         50         60 
MSCAEVMYHP QPYGASQYLP NPMAATTCPT AYYQPAPQPG QQKKLAVFSK MQDSLEVTLP 

        70         80         90        100        110        120 
SKQEEEDEEE EEEEKDQPAE MEYLNSRCVL FTYFQGDIGS VVDEHFSRAL GQAITLHPES 

       130        140        150        160        170        180 
AISKSKMGLT PLWRDSSALS SQRNSFPTSF WTSSYQPPPA PCLGGVHPDF QVTGPPGTFS 

       190        200        210        220        230        240 
AADPSPWPGH NLHQTGPAPP PAVSESWPYP LTSQVSPSYS HMHDVYMRHH HPHAHMHHRH 

       250        260        270        280        290        300 
RHHHHHHHPP AGSALDPSYG PLLMPSVHAA RIPAPQCDIT KTEPTTVTSA TSAWAGAFHG 

       310        320 
TVDIVPSVGF DTGLQHQDKS KESPWY 

« Hide

Isoform 2 [UniParc].

Checksum: 2FFF6081DD363630
Show »

FASTA32035,171

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]"Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
Maeda T., Chapman D.L., Stewart A.F.R.
J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC108709 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68870.1.
CH471110 Genomic DNA. Translation: EAW68871.1.
BC094780 mRNA. Translation: AAH94780.1.
RefSeqNP_057290.2. NM_016206.2.
XP_005264809.1. XM_005264752.2.
UniGeneHs.606507.
Hs.744116.

3D structure databases

ProteinModelPortalA8MV65.
SMRA8MV65. Positions 79-110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132991. 1 interaction.
STRING9606.ENSP00000381436.

PTM databases

PhosphoSiteA8MV65.

Proteomic databases

PaxDbA8MV65.
PRIDEA8MV65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383698; ENSP00000373199; ENSG00000206538. [A8MV65-2]
ENST00000398399; ENSP00000381436; ENSG00000206538. [A8MV65-1]
GeneID389136.
KEGGhsa:389136.
UCSCuc003dqn.3. human. [A8MV65-1]

Organism-specific databases

CTD389136.
GeneCardsGC03M087071.
H-InvDBHIX0003478.
HGNCHGNC:24327. VGLL3.
HPAHPA054983.
MIM609980. gene.
neXtProtNX_A8MV65.
PharmGKBPA142670628.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39971.
HOGENOMHOG000143402.
HOVERGENHBG057778.
InParanoidA8MV65.
OMAGHSLHQT.
OrthoDBEOG7K9K52.
PhylomeDBA8MV65.
TreeFamTF326340.

Gene expression databases

BgeeA8MV65.
CleanExHS_VGLL3.
GenevestigatorA8MV65.

Family and domain databases

InterProIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERPTHR15950. PTHR15950. 1 hit.
PfamPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTSM00711. TDU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi389136.
NextBio102627.
PROA8MV65.
SOURCESearch...

Entry information

Entry nameVGLL3_HUMAN
AccessionPrimary (citable) accession number: A8MV65
Secondary accession number(s): D3DU37, Q504T7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM