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Protein

Putative zinc finger protein 705G

Gene

ZNF705G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 705G
Gene namesi
Name:ZNF705G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:37134. ZNF705G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586029.

Polymorphism and mutation databases

BioMutaiZNF705G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Putative zinc finger protein 705GPRO_0000342396Add
BLAST

Proteomic databases

PaxDbiA8MUZ8.
PRIDEiA8MUZ8.

PTM databases

iPTMnetiA8MUZ8.
PhosphoSiteiA8MUZ8.

Expressioni

Gene expression databases

BgeeiENSG00000215372.
GenevisibleiA8MUZ8. HS.

Interactioni

Protein-protein interaction databases

BioGridi573352. 1 interaction.
STRINGi9606.ENSP00000383020.

Structurei

3D structure databases

ProteinModelPortaliA8MUZ8.
SMRiA8MUZ8. Positions 7-55, 115-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 7872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MUZ8.
OMAiSTEPHKQ.
OrthoDBiEOG091G0C0R.
PhylomeDBiA8MUZ8.
TreeFamiTF338497.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MUZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLKKLTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWREGR VFLQDQNPNR ESALKKTHMI SMHPITRKDA
110 120 130 140 150
STSMTMENSL ILEDPFECND SGEDCTRSST ITQCLLTHSG KKPYVSKQCG
160 170 180 190 200
KSLRNLLSTE PHKQIHTKGK SYQCNLCEKA YTNCFHLRRH KMTHTGERPY
210 220 230 240 250
ACHLCRKAFT QCSHLRRHEK THTGQRPYKC HQYGKVFIQS FNLQRHERTH
260 270 280 290 300
LGKKCYECDK SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSNLR
Length:300
Mass (Da):34,765
Last modified:July 1, 2008 - v2
Checksum:iFACCC34A68841184
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
BE466749 mRNA. No translation available.
CCDSiCCDS47773.1.
RefSeqiNP_001157929.1. NM_001164457.1.
UniGeneiHs.528391.

Genome annotation databases

EnsembliENST00000400156; ENSP00000383020; ENSG00000215372.
GeneIDi100131980.
KEGGihsa:100131980.
UCSCiuc033bav.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130360 Genomic DNA. No translation available.
BE466749 mRNA. No translation available.
CCDSiCCDS47773.1.
RefSeqiNP_001157929.1. NM_001164457.1.
UniGeneiHs.528391.

3D structure databases

ProteinModelPortaliA8MUZ8.
SMRiA8MUZ8. Positions 7-55, 115-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi573352. 1 interaction.
STRINGi9606.ENSP00000383020.

PTM databases

iPTMnetiA8MUZ8.
PhosphoSiteiA8MUZ8.

Polymorphism and mutation databases

BioMutaiZNF705G.

Proteomic databases

PaxDbiA8MUZ8.
PRIDEiA8MUZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400156; ENSP00000383020; ENSG00000215372.
GeneIDi100131980.
KEGGihsa:100131980.
UCSCiuc033bav.2. human.

Organism-specific databases

CTDi100131980.
GeneCardsiZNF705G.
HGNCiHGNC:37134. ZNF705G.
neXtProtiNX_A8MUZ8.
PharmGKBiPA165586029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MUZ8.
OMAiSTEPHKQ.
OrthoDBiEOG091G0C0R.
PhylomeDBiA8MUZ8.
TreeFamiTF338497.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii100131980.
PROiA8MUZ8.

Gene expression databases

BgeeiENSG00000215372.
GenevisibleiA8MUZ8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ705G_HUMAN
AccessioniPrimary (citable) accession number: A8MUZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.