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A8MUV8 (ZN727_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative zinc finger protein 727
Gene names
Name:ZNF727
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Putative zinc finger protein 727
PRO_0000346157

Regions

Domain4 – 7572KRAB
Zinc finger143 – 16725C2H2-type 1; degenerate
Zinc finger200 – 22223C2H2-type 2
Zinc finger228 – 25023C2H2-type 3
Zinc finger256 – 27823C2H2-type 4
Zinc finger284 – 30623C2H2-type 5
Zinc finger312 – 33423C2H2-type 6
Zinc finger340 – 36223C2H2-type 7
Zinc finger368 – 39023C2H2-type 8
Zinc finger396 – 41823C2H2-type 9
Zinc finger424 – 44623C2H2-type 10
Zinc finger452 – 47423C2H2-type 11

Sequences

Sequence LengthMass (Da)Tools
A8MUV8 [UniParc].

Last modified September 22, 2009. Version 3.
Checksum: DA3CC3D5F0BFD7A0

FASTA49957,972
        10         20         30         40         50         60 
MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP DLITYLEQRK 

        70         80         90        100        110        120 
EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL RKSGSCDLNT LRLKKDYQRV 

       130        140        150        160        170        180 
GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC GKAFGLCSIF TEHKKIFSRE KCYKCEECGK 

       190        200        210        220        230        240 
DCRLSDFTIQ KRIHTADRSY KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS 

       250        260        270        280        290        300 
SALTKHKRNH TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT 

       310        320        330        340        350        360 
KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT YSSTLISHKR 

       370        380        390        400        410        420 
IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE CGKSFTCSSN LIKHKRIHME 

       430        440        450        460        470        480 
VRPYKCEECG KTFKWFPDLT NHKRIHTGEK PYKCEECGKT FTCSSSLIKH KRSHTGDRPT 

       490 
SAKNVAKPLG GSQTLLNIR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC115220 Genomic DNA. No translation available.
CCDSCCDS55113.1.
RefSeqNP_001152994.1. NM_001159522.1.
UniGeneHs.640774.

3D structure databases

ProteinModelPortalA8MUV8.
SMRA8MUV8. Positions 4-44, 149-475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid138203. 1 interaction.

PTM databases

PhosphoSiteA8MUV8.

Proteomic databases

PRIDEA8MUV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000550760; ENSP00000447987; ENSG00000257482.
GeneID442319.
KEGGhsa:442319.
UCSCuc011kdm.2. human.

Organism-specific databases

CTD442319.
GeneCardsGC07P063506.
HGNCHGNC:22785. ZNF727.
HPAHPA061215.
neXtProtNX_A8MUV8.
PharmGKBPA162410231.
GenAtlasSearch...

Phylogenomic databases

InParanoidA8MUV8.
KOK09228.
OMARIHMEVR.
OrthoDBEOG7KSX7Q.
PhylomeDBA8MUV8.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeA8MUV8.
GenevestigatorA8MUV8.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi442319.
NextBio111007.

Entry information

Entry nameZN727_HUMAN
AccessionPrimary (citable) accession number: A8MUV8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM