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Protein

Putative zinc finger protein 727

Gene

ZNF727

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16725C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 727
Alternative name(s):
Zinc finger protein 727 pseudogene
Gene namesi
Name:ZNF727
Synonyms:ZNF727P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22785. ZNF727.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410231.

Polymorphism and mutation databases

BioMutaiZNF727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Putative zinc finger protein 727PRO_0000346157Add
BLAST

Proteomic databases

PRIDEiA8MUV8.

PTM databases

PhosphoSiteiA8MUV8.

Expressioni

Gene expression databases

BgeeiA8MUV8.
GenevestigatoriA8MUV8.

Organism-specific databases

HPAiHPA061215.

Interactioni

Protein-protein interaction databases

BioGridi138203. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA8MUV8.
SMRiA8MUV8. Positions 4-44, 140-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16725C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00790000122969.
InParanoidiA8MUV8.
KOiK09228.
OMAiRIHMEVR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA8MUV8.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MUV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP
60 70 80 90 100
DLITYLEQRK EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL
110 120 130 140 150
RKSGSCDLNT LRLKKDYQRV GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC
160 170 180 190 200
GKAFGLCSIF TEHKKIFSRE KCYKCEECGK DCRLSDFTIQ KRIHTADRSY
210 220 230 240 250
KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS SALTKHKRNH
260 270 280 290 300
TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT
310 320 330 340 350
KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT
360 370 380 390 400
YSSTLISHKR IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE
410 420 430 440 450
CGKSFTCSSN LIKHKRIHME VRPYKCEECG KTFKWFPDLT NHKRIHTGEK
460 470 480 490
PYKCEECGKT FTCSSSLIKH KRSHTGDRPT SAKNVAKPLG GSQTLLNIR
Length:499
Mass (Da):57,972
Last modified:September 22, 2009 - v3
Checksum:iDA3CC3D5F0BFD7A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115220 Genomic DNA. No translation available.
RefSeqiNP_001152994.1. NM_001159522.1.
UniGeneiHs.640774.

Genome annotation databases

EnsembliENST00000456806; ENSP00000485448; ENSG00000214652.
GeneIDi442319.
KEGGihsa:442319.
UCSCiuc011kdm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115220 Genomic DNA. No translation available.
RefSeqiNP_001152994.1. NM_001159522.1.
UniGeneiHs.640774.

3D structure databases

ProteinModelPortaliA8MUV8.
SMRiA8MUV8. Positions 4-44, 140-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138203. 1 interaction.

PTM databases

PhosphoSiteiA8MUV8.

Polymorphism and mutation databases

BioMutaiZNF727.

Proteomic databases

PRIDEiA8MUV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456806; ENSP00000485448; ENSG00000214652.
GeneIDi442319.
KEGGihsa:442319.
UCSCiuc011kdm.2. human.

Organism-specific databases

CTDi442319.
HGNCiHGNC:22785. ZNF727.
HPAiHPA061215.
neXtProtiNX_A8MUV8.
PharmGKBiPA162410231.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00790000122969.
InParanoidiA8MUV8.
KOiK09228.
OMAiRIHMEVR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA8MUV8.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii442319.
NextBioi111007.

Gene expression databases

BgeeiA8MUV8.
GenevestigatoriA8MUV8.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN727_HUMAN
AccessioniPrimary (citable) accession number: A8MUV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 22, 2009
Last modified: May 27, 2015
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.