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A8MUV8

- ZN727_HUMAN

UniProt

A8MUV8 - ZN727_HUMAN

Protein

Putative zinc finger protein 727

Gene

ZNF727P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 3 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative zinc finger protein 727
    Alternative name(s):
    Zinc finger protein 727 pseudogene
    Gene namesi
    Name:ZNF727P
    Synonyms:ZNF727
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:22785. ZNF727P.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Putative zinc finger protein 727PRO_0000346157Add
    BLAST

    Proteomic databases

    PRIDEiA8MUV8.

    PTM databases

    PhosphoSiteiA8MUV8.

    Expressioni

    Gene expression databases

    BgeeiA8MUV8.
    GenevestigatoriA8MUV8.

    Organism-specific databases

    HPAiHPA061215.

    Interactioni

    Protein-protein interaction databases

    BioGridi138203. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MUV8.
    SMRiA8MUV8. Positions 4-44, 149-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    InParanoidiA8MUV8.
    KOiK09228.
    OMAiRIHMEVR.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiA8MUV8.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MUV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLTFRDVA VEFSPEEWEC LDSAQQRLYR DVMLENYGNL FSLGLAIFKP    50
    DLITYLEQRK EPWNARRQKT VAKHPAGSLH FTAEILLEHD INDSFQKVIL 100
    RKSGSCDLNT LRLKKDYQRV GNCKGQKSSY NGIHQCLSAT RSKTCQYNKC 150
    GKAFGLCSIF TEHKKIFSRE KCYKCEECGK DCRLSDFTIQ KRIHTADRSY 200
    KCEECGKACK KFSNLTEHNR VHTGKKPYKC EECGKTFTCS SALTKHKRNH 250
    TGDRPYKCEE CHKAFRCCSD LTKHKRIHTG EKPYKCKECH KAFRCCSDLT 300
    KHKRIHTGEK PYKCNECGKA FMWISALSQH NRIHTGEKPY ICEECGKAFT 350
    YSSTLISHKR IHMELRPYKC EECGKTFKWF SDLTNHKRIH TGEKPYKCEE 400
    CGKSFTCSSN LIKHKRIHME VRPYKCEECG KTFKWFPDLT NHKRIHTGEK 450
    PYKCEECGKT FTCSSSLIKH KRSHTGDRPT SAKNVAKPLG GSQTLLNIR 499
    Length:499
    Mass (Da):57,972
    Last modified:September 22, 2009 - v3
    Checksum:iDA3CC3D5F0BFD7A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115220 Genomic DNA. No translation available.
    CCDSiCCDS55113.1.
    RefSeqiNP_001152994.1. NM_001159522.1.
    UniGeneiHs.640774.

    Genome annotation databases

    GeneIDi442319.
    KEGGihsa:442319.
    UCSCiuc011kdm.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115220 Genomic DNA. No translation available.
    CCDSi CCDS55113.1.
    RefSeqi NP_001152994.1. NM_001159522.1.
    UniGenei Hs.640774.

    3D structure databases

    ProteinModelPortali A8MUV8.
    SMRi A8MUV8. Positions 4-44, 149-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 138203. 1 interaction.

    PTM databases

    PhosphoSitei A8MUV8.

    Proteomic databases

    PRIDEi A8MUV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 442319.
    KEGGi hsa:442319.
    UCSCi uc011kdm.2. human.

    Organism-specific databases

    CTDi 442319.
    GeneCardsi GC07P063506.
    HGNCi HGNC:22785. ZNF727P.
    HPAi HPA061215.
    neXtProti NX_A8MUV8.
    PharmGKBi PA162410231.
    GenAtlasi Search...

    Phylogenomic databases

    InParanoidi A8MUV8.
    KOi K09228.
    OMAi RIHMEVR.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi A8MUV8.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 442319.
    NextBioi 111007.

    Gene expression databases

    Bgeei A8MUV8.
    Genevestigatori A8MUV8.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiZN727_HUMAN
    AccessioniPrimary (citable) accession number: A8MUV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 61 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3