A8MUV4 (A8MUV4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Forkhead box protein P2 Ensembl ENSP00000377135

Gene names

Name:

FOXP2 Ensembl ENSP00000377135

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000377135

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	692 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 fork-head DNA-binding domain. SAAS SAAS018122
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000377135

Ontologies

Keywords
Ligand	DNA-binding SAAS SAAS018122
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8MUV4 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 3272E07ED3613837	FASTA	692	76,982
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 130 140 150 160 170 180 LLQQQQAVML QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH PGKQAKEQQQ 190 200 210 220 230 240 QQQQQQLAAQ QLVFQQQLLQ MQQLQQQQHL LSLQRQGLIS IPPGQAALPV QSLPQAGLSP 250 260 270 280 290 300 AEIQQLWKEV TGVHSMEDNG IKHGGLDLTT NNSSSTTSSN TSKASPPITH HSIVNGQSSV 310 320 330 340 350 360 LSARRDSSSH EETGASHTLY GHGVCKWPGC ESICEDFGQF LKHLNNEHAL DDRSTAQCRV 370 380 390 400 410 420 QMQVVQQLEI QLSKERERLQ AMMTHLHMRP SEPKPSPKPL NLVSSVTMSK NMLETSPQSL 430 440 450 460 470 480 PQTPTTPTAP VTPITQGPSV ITPASVPNVG AIRRRHSDKY NIPMSSEIAP NYEFYKNADV 490 500 510 520 530 540 RPPFTYATLI RQAIMESSDR QLTLNEIYSW FTRTFAYFRR NAATWKNAVR HNLSLHKCFV 550 560 570 580 590 600 RVENVKGAVW TVDEVEYQKR RSQKITGSPT LVKNIPTSLG YGAALNASLQ AALAESSLPL 610 620 630 640 650 660 LSNPGLINNA SSGLLQAVHE DLNGSLDHID SNGNSSPGCS PQPHIHSIHV KEEPVIAEDE 670 680 690 DCPMSLVTTA NHSPELEDDR EIEEEPLSED LE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC003992 Genomic DNA. No translation available. AC020606 Genomic DNA. No translation available. AC073626 Genomic DNA. No translation available. AC074000 Genomic DNA. No translation available. AC092148 Genomic DNA. No translation available. AC092606 Genomic DNA. No translation available.
IPI	IPI00170880.
3D structure databases
ProteinModelPortal	A8MUV4.
SMR	A8MUV4. Positions 328-386, 480-561.
ModBase	Search...
Protein-protein interaction databases
STRING	A8MUV4.
Proteomic databases
PRIDE	A8MUV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393498; ENSP00000377135; ENSG00000128573.
Organism-specific databases
HGNC	HGNC:13875. FOXP2.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000092089.
HOVERGEN	HBG051657.
Gene expression databases
ArrayExpress	A8MUV4.
Bgee	A8MUV4.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXP2. human.
NextBio	35464916.

Entry information

Entry name

A8MUV4_HUMAN

Accession

Primary (citable) accession number: A8MUV4

Entry history

Integrated into UniProtKB/TrEMBL:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.