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Protein
Submitted name:

Retinoic acid receptor alpha

Gene

RARA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi101 – 176Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Retinoic acid receptor alphaImported
Submitted name:
Retinoic acid receptor, alpha, isoform CRA_eImported
Gene namesi
Name:RARAImported
ORF Names:hCG_2007196Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9864. RARA.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131759.

PTM / Processingi

Proteomic databases

MaxQBiA8MUP8.
PRIDEiA8MUP8.

Expressioni

Gene expression databases

BgeeiENSG00000131759.
ExpressionAtlasiA8MUP8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA8MUP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 176Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00870000136372.
HOGENOMiHOG000010312.
HOVERGENiHBG005606.
OrthoDBiEOG091G0XCQ.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MUP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSQTMTQAG VSFRHSVRAA QCHTRVPNTW PRATRPYASC RRSPRLRGRW
60 70 80 90 100
PGSAGQGAGG RAPRAGWRAG DVTGSAIETQ SSSSEEIVPS PPSPPPLPRI
110 120 130 140 150
YKPCFVCQDK SSGYHYGVSA CEGCKGFFRR SIQKNMVYTC HRDKNCIINK
160 170 180 190 200
VTRNRCQYCR LQKCFEVGMS KESVRNDRNK KKKEVPKPEC SESYTLTPEV
210 220 230 240 250
GELIEKVRKA HQETFPALCQ LGKYTTNNSS EQRVSLDIDL WDKFSELSTK
260 270 280 290 300
CIIKTVEFAK QLPGFTTLTI ADQITLLKAA CLDILILRIC TRYTPEQDTM
310 320 330 340 350
TFSDGLTLNR TQMHNAGFGP LTDLVFAFAN QLLPLEMDDA ETGLLSAICL
360 370 380 390 400
ICGDRQDLEQ PDRVDMLQEP LLEALKVYVR KRRPSRPHMF PKMLMKITDL
410 420 430 440 450
RSISAKGAER VITLKMEIPG SMPPLIQEML ENSEGLDTLS GQPGGGGRDG
460 470
GGLAPPPGSC SPSLSPSSNR SSPATHSP
Length:478
Mass (Da):52,907
Last modified:December 4, 2007 - v1
Checksum:i82F4371E70732E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC080112 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60657.1.
RefSeqiXP_005257609.1. XM_005257552.4.
UniGeneiHs.654583.

Genome annotation databases

EnsembliENST00000394086; ENSP00000377648; ENSG00000131759.
GeneIDi5914.
UCSCiuc060eyj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC080112 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60657.1.
RefSeqiXP_005257609.1. XM_005257552.4.
UniGeneiHs.654583.

3D structure databases

ProteinModelPortaliA8MUP8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA8MUP8.
PRIDEiA8MUP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394086; ENSP00000377648; ENSG00000131759.
GeneIDi5914.
UCSCiuc060eyj.1. human.

Organism-specific databases

CTDi5914.
HGNCiHGNC:9864. RARA.
OpenTargetsiENSG00000131759.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00870000136372.
HOGENOMiHOG000010312.
HOVERGENiHBG005606.
OrthoDBiEOG091G0XCQ.

Miscellaneous databases

ChiTaRSiRARA. human.
GenomeRNAii5914.

Gene expression databases

BgeeiENSG00000131759.
ExpressionAtlasiA8MUP8. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA8MUP8_HUMAN
AccessioniPrimary (citable) accession number: A8MUP8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: March 15, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.