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A8MUK1

- U17L5_HUMAN

UniProt

A8MUK1 - U17L5_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 5

Gene

USP17L5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891NucleophilePROSITE-ProRule annotation
    Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 17-like protein 5
    Ubiquitin thioesterase 17-like protein 5
    Ubiquitin-specific-processing protease 17-like protein 5
    Gene namesi
    Name:USP17L5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:37177. USP17L5.

    Subcellular locationi

    Nucleus By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165664776.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 5PRO_0000331647Add
    BLAST

    Proteomic databases

    PRIDEiA8MUK1.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MUK1.

    Organism-specific databases

    HPAiHPA045642.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MUK1.
    SMRiA8MUK1. Positions 49-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 375296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000144638.
    HOVERGENiHBG007129.
    InParanoidiA8MUK1.
    KOiK11845.
    OMAiAKPEELN.
    OrthoDBiEOG73NG35.
    PhylomeDBiA8MUK1.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MUK1-1 [UniParc]FASTAAdd to Basket

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    MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD    50
    LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY 100
    TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA 150
    AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY 200
    WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL AKPEELNGEN 250
    AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC 300
    LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD 350
    DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD 400
    RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF 450
    NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM 500
    NTGTLASLRG RARRSKGKNK HSKRALLVCQ 530
    Length:530
    Mass (Da):59,683
    Last modified:April 29, 2008 - v2
    Checksum:i625A1B0A52EFE2FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC116655 Genomic DNA. No translation available.
    CCDSiCCDS59467.1.
    RefSeqiNP_001229258.1. NM_001242329.1.
    UniGeneiHs.740243.

    Genome annotation databases

    EnsembliENST00000507227; ENSP00000425955; ENSG00000227140.
    GeneIDi728386.
    KEGGihsa:728386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC116655 Genomic DNA. No translation available.
    CCDSi CCDS59467.1.
    RefSeqi NP_001229258.1. NM_001242329.1.
    UniGenei Hs.740243.

    3D structure databases

    ProteinModelPortali A8MUK1.
    SMRi A8MUK1. Positions 49-372.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A8MUK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507227 ; ENSP00000425955 ; ENSG00000227140 .
    GeneIDi 728386.
    KEGGi hsa:728386.

    Organism-specific databases

    CTDi 728386.
    GeneCardsi GC04P009342.
    HGNCi HGNC:37177. USP17L5.
    HPAi HPA045642.
    neXtProti NX_A8MUK1.
    PharmGKBi PA165664776.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000144638.
    HOVERGENi HBG007129.
    InParanoidi A8MUK1.
    KOi K11845.
    OMAi AKPEELN.
    OrthoDBi EOG73NG35.
    PhylomeDBi A8MUK1.
    TreeFami TF315281.

    Miscellaneous databases

    GenomeRNAii 728386.
    NextBioi 127023.
    PROi A8MUK1.

    Gene expression databases

    Genevestigatori A8MUK1.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."
      Burrows J.F., McGrattan M.J., Johnston J.A.
      Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.
    3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."
      Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.
      BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiU17L5_HUMAN
    AccessioniPrimary (citable) accession number: A8MUK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3