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Protein

Putative PDZ domain-containing protein PDZK1P1

Gene

PDZK1P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative PDZ domain-containing protein PDZK1P1Curated
Alternative name(s):
PDZ domain-containing 1 pseudogene 1Imported
PDZ domain-containing 1 pseudogene 2Imported
Gene namesi
Name:PDZK1P1Imported
Synonyms:PDZK1P2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31974. PDZK1P1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003443681 – 402Putative PDZ domain-containing protein PDZK1P1Add BLAST402

Proteomic databases

MaxQBiA8MUH7.
PaxDbiA8MUH7.
PRIDEiA8MUH7.

PTM databases

iPTMnetiA8MUH7.
PhosphoSitePlusiA8MUH7.

Expressioni

Organism-specific databases

HPAiHPA005755.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342143.

Structurei

3D structure databases

ProteinModelPortaliA8MUH7.
SMRiA8MUH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 93PDZ 1PROSITE-ProRule annotationAdd BLAST82
Domaini121 – 206PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini261 – 341PDZ 3PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the NHER family.Curated
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410ITAE. Eukaryota.
ENOG410ZYGE. LUCA.
HOVERGENiHBG082115.
InParanoidiA8MUH7.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 3 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MUH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGGVQTWTQ PRLCYLVKEG GSHGFSLKTV QGKKGVYMTD ITPQGVAMRA
60 70 80 90 100
GVLADDHLIE VNGENVEDAS HEEVVEKVKK SGSRVMFLLV DKETDKRHVE
110 120 130 140 150
QKIQFKRETA SLKLLPHQPR IVEMKKGSNG YGFYLRAGSE QKGWGRVGQI
160 170 180 190 200
IKDIDSGSPA EEAGLKNNDL VVAVNGESVE TLDHDSVVEM IRKGGDQTSL
210 220 230 240 250
LVVDKETDNM YRLAHFSPFL YYQSQELPNG SVKEAPAPTP TSLEVSSPPD
260 270 280 290 300
TTEEEDHKPK LCRLAKGENG YGFHLNAIRG LPGSFIKEVQ KGGPADLAGL
310 320 330 340 350
EDEDVIIEVN GVNVLDEPYE KVVDRIQSSG KNVTLLVCGK KAYDYFQAKK
360 370 380 390 400
IPIVSSLADP LDTPPDSKEG IVVESKHDSH MAKERAHSTA SHSSSNSEDT

EM
Length:402
Mass (Da):44,056
Last modified:July 22, 2008 - v2
Checksum:i1D111B3817DA9925
GO
Isoform 2 (identifier: A8MUH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-147: Missing.
     268-273: ENGYGF → TEGRSC
     274-402: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,541
Checksum:iDEF9233B27B634E6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034752143 – 147Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_034753268 – 273ENGYGF → TEGRSC in isoform 2. 1 Publication6
Alternative sequenceiVSP_034754274 – 402Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126719 mRNA. No translation available.
AL356004 Genomic DNA. No translation available.
BX537254 Genomic DNA. No translation available.
UniGeneiHs.696575.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126719 mRNA. No translation available.
AL356004 Genomic DNA. No translation available.
BX537254 Genomic DNA. No translation available.
UniGeneiHs.696575.

3D structure databases

ProteinModelPortaliA8MUH7.
SMRiA8MUH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342143.

PTM databases

iPTMnetiA8MUH7.
PhosphoSitePlusiA8MUH7.

Proteomic databases

MaxQBiA8MUH7.
PaxDbiA8MUH7.
PRIDEiA8MUH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPDZK1P1.
HGNCiHGNC:31974. PDZK1P1.
HPAiHPA005755.
neXtProtiNX_A8MUH7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITAE. Eukaryota.
ENOG410ZYGE. LUCA.
HOVERGENiHBG082115.
InParanoidiA8MUH7.

Enzyme and pathway databases

BioCyciZFISH:G66-31918-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 3 hits.
[Graphical view]
SMARTiSM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 3 hits.
PROSITEiPS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDZ1P_HUMAN
AccessioniPrimary (citable) accession number: A8MUH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Putative protein with similarity to PDZK1 C-terminus.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.