Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8MU46 (SMTL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Smoothelin-like protein 1
Gene names
Name:SMTNL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity By similarity.

Subunit structure

Interacts with PPP1R12A By similarity.

Subcellular location

Cytoplasmmyofibril. CytoplasmmyofibrilsarcomereI band By similarity. CytoplasmmyofibrilsarcomereM line By similarity. Nucleus By similarity. Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm By similarity. Phosphorylation at Ser-301 promotes translocation to the nucleus By similarity. Ref.2

Tissue specificity

Expressed in striated muscles, specifically in type 2a fibers (at protein level). Ref.2 Ref.3

Post-translational modification

Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine By similarity.

Sequence similarities

Belongs to the smoothelin family.

Contains 1 CH (calponin-homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Smoothelin-like protein 1
PRO_0000317275

Regions

Domain341 – 444104CH
Region439 – 45719Calmodulin-binding By similarity
Coiled coil123 – 14523 Potential
Compositional bias44 – 245202Glu-rich

Amino acid modifications

Modified residue2991Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A8MU46 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 54C5DC43EECC3C66

FASTA45748,953
        10         20         30         40         50         60 
MEQKEGKLSE DGTTVSPAAD NPEMSGGGAP AEETKGTAGK AINEGPPTES GKQEKAPAED 

        70         80         90        100        110        120 
GMSAELQGEA NGLDEVKVES QREAGGKEDA EAELKKEDGE KEETTVGSQE MTGRKEETKS 

       130        140        150        160        170        180 
EPKEAEEKES TLASEKQKAE EKEAKPESGQ KADANDRDKP EPKATVEEED AKTASQEETV 

       190        200        210        220        230        240 
VEDEAKAEPK EPDGKEEAKH GAKEEADEPG SPSEEQEQDV EKEPEGGAGV IPSSPEEWPE 

       250        260        270        280        290        300 
SPTGEGHNLS TDGLGPDCVA SGQTSPSASE SSPSDVPQSP PESPSSGEKK EKAPERRVSA 

       310        320        330        340        350        360 
PARPRGPRAQ NRKAIVDKFG GAASGPTALF RNTKAAGAAI GGVKNMLLEW CRAMTKKYEH 

       370        380        390        400        410        420 
VDIQNFSSSW SSGMAFCALI HKFFPDAFDY AELDPAKRRH NFTLAFSTAE KLADCAQLLD 

       430        440        450 
VDDMVRLAVP DSKCVYTYIQ ELYRSLVQKG LVKTKKK 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle."
Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A.
J. Biol. Chem. 283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]"Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy."
Lontay B., Bodoor K., Weitzel D.H., Loiselle D., Fortner C., Lengyel S., Zheng D., Devente J., Hickner R., Haystead T.A.
J. Biol. Chem. 285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP002893 Genomic DNA. No translation available.
UniGeneHs.68756.

3D structure databases

ProteinModelPortalA8MU46.
SMRA8MU46. Positions 342-457.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000406485.

Proteomic databases

PaxDbA8MU46.
PRIDEA8MU46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399154; ENSP00000382108; ENSG00000214872.

Organism-specific databases

GeneCardsGC11P057309.
HGNCHGNC:32394. SMTNL1.
HPAHPA040264.
MIM613664. gene.
neXtProtNX_A8MU46.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5069.
HOGENOMHOG000154352.
HOVERGENHBG095368.
InParanoidA8MU46.
PhylomeDBA8MU46.

Gene expression databases

ArrayExpressA8MU46.
BgeeA8MU46.
CleanExHS_SMTNL1.
GenevestigatorA8MU46.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
InterProIPR001715. CH-domain.
[Graphical view]
PfamPF00307. CH. 1 hit.
[Graphical view]
SMARTSM00033. CH. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
PROSITEPS50021. CH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA8MU46.
SOURCESearch...

Entry information

Entry nameSMTL1_HUMAN
AccessionPrimary (citable) accession number: A8MU46
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM