Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8MU46

- SMTL1_HUMAN

UniProt

A8MU46 - SMTL1_HUMAN

Protein

Smoothelin-like protein 1

Gene

SMTNL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity By similarity.By similarity

    GO - Biological processi

    1. negative regulation of vasodilation Source: UniProtKB
    2. positive regulation of vasoconstriction Source: UniProtKB

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Smoothelin-like protein 1
    Gene namesi
    Name:SMTNL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:32394. SMTNL1.

    Subcellular locationi

    Cytoplasmmyofibril 1 Publication. CytoplasmmyofibrilsarcomereI band By similarity. CytoplasmmyofibrilsarcomereM line By similarity. Nucleus By similarity
    Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm By similarity. Phosphorylation at Ser-301 promotes translocation to the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. contractile fiber Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. I band Source: UniProtKB-SubCell
    4. M band Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Smoothelin-like protein 1PRO_0000317275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei299 – 2991PhosphoserineBy similarity

    Post-translational modificationi

    Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA8MU46.
    PaxDbiA8MU46.
    PRIDEiA8MU46.

    Expressioni

    Tissue specificityi

    Expressed in striated muscles, specifically in type 2a fibers (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiA8MU46.
    BgeeiA8MU46.
    CleanExiHS_SMTNL1.
    GenevestigatoriA8MU46.

    Organism-specific databases

    HPAiHPA040264.

    Interactioni

    Subunit structurei

    Interacts with PPP1R12A.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000406485.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MU46.
    SMRiA8MU46. Positions 342-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini341 – 444104CHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni439 – 45719Calmodulin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili123 – 14523Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 245202Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the smoothelin family.Curated
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5069.
    HOGENOMiHOG000154352.
    HOVERGENiHBG095368.
    InParanoidiA8MU46.
    PhylomeDBiA8MU46.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    InterProiIPR001715. CH-domain.
    [Graphical view]
    PfamiPF00307. CH. 1 hit.
    [Graphical view]
    SMARTiSM00033. CH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    PROSITEiPS50021. CH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MU46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQKEGKLSE DGTTVSPAAD NPEMSGGGAP AEETKGTAGK AINEGPPTES    50
    GKQEKAPAED GMSAELQGEA NGLDEVKVES QREAGGKEDA EAELKKEDGE 100
    KEETTVGSQE MTGRKEETKS EPKEAEEKES TLASEKQKAE EKEAKPESGQ 150
    KADANDRDKP EPKATVEEED AKTASQEETV VEDEAKAEPK EPDGKEEAKH 200
    GAKEEADEPG SPSEEQEQDV EKEPEGGAGV IPSSPEEWPE SPTGEGHNLS 250
    TDGLGPDCVA SGQTSPSASE SSPSDVPQSP PESPSSGEKK EKAPERRVSA 300
    PARPRGPRAQ NRKAIVDKFG GAASGPTALF RNTKAAGAAI GGVKNMLLEW 350
    CRAMTKKYEH VDIQNFSSSW SSGMAFCALI HKFFPDAFDY AELDPAKRRH 400
    NFTLAFSTAE KLADCAQLLD VDDMVRLAVP DSKCVYTYIQ ELYRSLVQKG 450
    LVKTKKK 457
    Length:457
    Mass (Da):48,953
    Last modified:December 4, 2007 - v1
    Checksum:i54C5DC43EECC3C66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002893 Genomic DNA. No translation available.
    UniGeneiHs.68756.

    Genome annotation databases

    EnsembliENST00000399154; ENSP00000382108; ENSG00000214872.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002893 Genomic DNA. No translation available.
    UniGenei Hs.68756.

    3D structure databases

    ProteinModelPortali A8MU46.
    SMRi A8MU46. Positions 342-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000406485.

    Proteomic databases

    MaxQBi A8MU46.
    PaxDbi A8MU46.
    PRIDEi A8MU46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399154 ; ENSP00000382108 ; ENSG00000214872 .

    Organism-specific databases

    GeneCardsi GC11P057309.
    HGNCi HGNC:32394. SMTNL1.
    HPAi HPA040264.
    MIMi 613664. gene.
    neXtProti NX_A8MU46.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5069.
    HOGENOMi HOG000154352.
    HOVERGENi HBG095368.
    InParanoidi A8MU46.
    PhylomeDBi A8MU46.

    Miscellaneous databases

    PROi A8MU46.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A8MU46.
    Bgeei A8MU46.
    CleanExi HS_SMTNL1.
    Genevestigatori A8MU46.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    InterProi IPR001715. CH-domain.
    [Graphical view ]
    Pfami PF00307. CH. 1 hit.
    [Graphical view ]
    SMARTi SM00033. CH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    PROSITEi PS50021. CH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle."
      Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A.
      J. Biol. Chem. 283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. "Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy."
      Lontay B., Bodoor K., Weitzel D.H., Loiselle D., Fortner C., Lengyel S., Zheng D., Devente J., Hickner R., Haystead T.A.
      J. Biol. Chem. 285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSMTL1_HUMAN
    AccessioniPrimary (citable) accession number: A8MU46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3