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A8MU46

- SMTL1_HUMAN

UniProt

A8MU46 - SMTL1_HUMAN

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Protein

Smoothelin-like protein 1

Gene

SMTNL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).By similarity

GO - Biological processi

  1. negative regulation of vasodilation Source: UniProtKB
  2. positive regulation of vasoconstriction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothelin-like protein 1
Gene namesi
Name:SMTNL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:32394. SMTNL1.

Subcellular locationi

Cytoplasmmyofibril 1 Publication. CytoplasmmyofibrilsarcomereI band By similarity. CytoplasmmyofibrilsarcomereM line By similarity. Nucleus By similarity
Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity).By similarity

GO - Cellular componenti

  1. contractile fiber Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Smoothelin-like protein 1PRO_0000317275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991PhosphoserineBy similarity

Post-translational modificationi

Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA8MU46.
PaxDbiA8MU46.
PRIDEiA8MU46.

Expressioni

Tissue specificityi

Expressed in striated muscles, specifically in type 2a fibers (at protein level).2 Publications

Gene expression databases

BgeeiA8MU46.
CleanExiHS_SMTNL1.
ExpressionAtlasiA8MU46. baseline and differential.
GenevestigatoriA8MU46.

Organism-specific databases

HPAiHPA040264.

Interactioni

Subunit structurei

Interacts with PPP1R12A.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000406485.

Structurei

3D structure databases

ProteinModelPortaliA8MU46.
SMRiA8MU46. Positions 342-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 444104CHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni439 – 45719Calmodulin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili123 – 14523Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 245202Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the smoothelin family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000154352.
HOVERGENiHBG095368.
InParanoidiA8MU46.
PhylomeDBiA8MU46.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MU46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQKEGKLSE DGTTVSPAAD NPEMSGGGAP AEETKGTAGK AINEGPPTES
60 70 80 90 100
GKQEKAPAED GMSAELQGEA NGLDEVKVES QREAGGKEDA EAELKKEDGE
110 120 130 140 150
KEETTVGSQE MTGRKEETKS EPKEAEEKES TLASEKQKAE EKEAKPESGQ
160 170 180 190 200
KADANDRDKP EPKATVEEED AKTASQEETV VEDEAKAEPK EPDGKEEAKH
210 220 230 240 250
GAKEEADEPG SPSEEQEQDV EKEPEGGAGV IPSSPEEWPE SPTGEGHNLS
260 270 280 290 300
TDGLGPDCVA SGQTSPSASE SSPSDVPQSP PESPSSGEKK EKAPERRVSA
310 320 330 340 350
PARPRGPRAQ NRKAIVDKFG GAASGPTALF RNTKAAGAAI GGVKNMLLEW
360 370 380 390 400
CRAMTKKYEH VDIQNFSSSW SSGMAFCALI HKFFPDAFDY AELDPAKRRH
410 420 430 440 450
NFTLAFSTAE KLADCAQLLD VDDMVRLAVP DSKCVYTYIQ ELYRSLVQKG

LVKTKKK
Length:457
Mass (Da):48,953
Last modified:December 4, 2007 - v1
Checksum:i54C5DC43EECC3C66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002893 Genomic DNA. No translation available.
UniGeneiHs.68756.

Genome annotation databases

EnsembliENST00000399154; ENSP00000382108; ENSG00000214872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002893 Genomic DNA. No translation available.
UniGenei Hs.68756.

3D structure databases

ProteinModelPortali A8MU46.
SMRi A8MU46. Positions 342-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000406485.

Proteomic databases

MaxQBi A8MU46.
PaxDbi A8MU46.
PRIDEi A8MU46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399154 ; ENSP00000382108 ; ENSG00000214872 .

Organism-specific databases

GeneCardsi GC11P057309.
HGNCi HGNC:32394. SMTNL1.
HPAi HPA040264.
MIMi 613664. gene.
neXtProti NX_A8MU46.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5069.
GeneTreei ENSGT00760000118856.
HOGENOMi HOG000154352.
HOVERGENi HBG095368.
InParanoidi A8MU46.
PhylomeDBi A8MU46.

Miscellaneous databases

PROi A8MU46.
SOURCEi Search...

Gene expression databases

Bgeei A8MU46.
CleanExi HS_SMTNL1.
ExpressionAtlasi A8MU46. baseline and differential.
Genevestigatori A8MU46.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
InterProi IPR001715. CH-domain.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
PROSITEi PS50021. CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle."
    Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A.
    J. Biol. Chem. 283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy."
    Lontay B., Bodoor K., Weitzel D.H., Loiselle D., Fortner C., Lengyel S., Zheng D., Devente J., Hickner R., Haystead T.A.
    J. Biol. Chem. 285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSMTL1_HUMAN
AccessioniPrimary (citable) accession number: A8MU46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3