Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8MTY7

- KRA97_HUMAN

UniProt

A8MTY7 - KRA97_HUMAN

Protein

Keratin-associated protein 9-7

Gene

KRTAP9-7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 9-7
    Gene namesi
    Name:KRTAP9-7
    Synonyms:KAP9.7, KRTAP9.7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18915. KRTAP9-7.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Keratin-associated protein 9-7PRO_0000332259Add
    BLAST

    Proteomic databases

    PaxDbiA8MTY7.
    PRIDEiA8MTY7.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MTY7.

    Organism-specific databases

    HPAiHPA042482.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000375149.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MTY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati8 – 1251
    Repeati13 – 1752
    Repeati32 – 3653
    Repeati37 – 4154
    Repeati46 – 5055
    Repeati51 – 5556
    Repeati56 – 6057
    Repeati61 – 6558
    Repeati75 – 7959
    Repeati80 – 84510
    Repeati85 – 89511
    Repeati90 – 94512
    Repeati100 – 104513
    Repeati139 – 143514
    Repeati144 – 148515
    Repeati149 – 153516
    Repeati163 – 167517

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 16716017 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]Add
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 9 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiKOG4726.
    HOGENOMiHOG000234030.
    InParanoidiA8MTY7.
    OMAiCRRACYH.
    OrthoDBiEOG7WMCNT.
    PhylomeDBiA8MTY7.
    TreeFamiTF351356.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.
    PfamiPF13885. Keratin_B2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MTY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT    50
    CCQNTCCRTT CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC 100
    CQPSSCAPIY CRRTCYHPTS VYLPGCLNQS CGSSCCQPCC RPACCETTCC 150
    RTTCFQPTCV TSCCQPACC 169
    Length:169
    Mass (Da):17,793
    Last modified:December 4, 2007 - v1
    Checksum:i17320FA5E5159495
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231T → I.
    Corresponds to variant rs4890107 [ dbSNP | Ensembl ].
    VAR_042995
    Natural varianti130 – 1301S → N.
    Corresponds to variant rs12948628 [ dbSNP | Ensembl ].
    VAR_042996

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSiCCDS59287.1.
    RefSeqiNP_001264261.1. NM_001277332.1.

    Genome annotation databases

    EnsembliENST00000391354; ENSP00000375149; ENSG00000180386.
    ENST00000573531; ENSP00000460369; ENSG00000262221.
    GeneIDi100505724.
    KEGGihsa:100505724.
    UCSCiuc031rah.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006070 Genomic DNA. No translation available.
    CCDSi CCDS59287.1.
    RefSeqi NP_001264261.1. NM_001277332.1.

    3D structure databases

    ProteinModelPortali A8MTY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000375149.

    Proteomic databases

    PaxDbi A8MTY7.
    PRIDEi A8MTY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391354 ; ENSP00000375149 ; ENSG00000180386 .
    ENST00000573531 ; ENSP00000460369 ; ENSG00000262221 .
    GeneIDi 100505724.
    KEGGi hsa:100505724.
    UCSCi uc031rah.1. human.

    Organism-specific databases

    CTDi 100505724.
    GeneCardsi GC17P039431.
    HGNCi HGNC:18915. KRTAP9-7.
    HPAi HPA042482.
    neXtProti NX_A8MTY7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi KOG4726.
    HOGENOMi HOG000234030.
    InParanoidi A8MTY7.
    OMAi CRRACYH.
    OrthoDBi EOG7WMCNT.
    PhylomeDBi A8MTY7.
    TreeFami TF351356.

    Miscellaneous databases

    GenomeRNAii 100505724.
    NextBioi 34053914.
    PROi A8MTY7.

    Gene expression databases

    Genevestigatori A8MTY7.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    Pfami PF13885. Keratin_B2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKRA97_HUMAN
    AccessioniPrimary (citable) accession number: A8MTY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3