Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8MTY7 (KRA97_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 9-7
Gene names
Name:KRTAP9-7
Synonyms:KAP9.7, KRTAP9.7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.

Subunit structure

Interacts with hair keratins By similarity.

Sequence similarities

Belongs to the KRTAP type 9 family.

Ontologies

Keywords
   Cellular componentKeratin
   Coding sequence diversityPolymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Keratin-associated protein 9-7
PRO_0000332259

Regions

Repeat8 – 1251
Repeat13 – 1752
Repeat32 – 3653
Repeat37 – 4154
Repeat46 – 5055
Repeat51 – 5556
Repeat56 – 6057
Repeat61 – 6558
Repeat75 – 7959
Repeat80 – 84510
Repeat85 – 89511
Repeat90 – 94512
Repeat100 – 104513
Repeat139 – 143514
Repeat144 – 148515
Repeat149 – 153516
Repeat163 – 167517
Region8 – 16716017 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]

Natural variations

Natural variant231T → I.
Corresponds to variant rs4890107 [ dbSNP | Ensembl ].
VAR_042995
Natural variant1301S → N.
Corresponds to variant rs12948628 [ dbSNP | Ensembl ].
VAR_042996

Sequences

Sequence LengthMass (Da)Tools
A8MTY7 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 17320FA5E5159495

FASTA16917,793
        10         20         30         40         50         60 
MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT 

        70         80         90        100        110        120 
CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC CQPSSCAPIY CRRTCYHPTS 

       130        140        150        160 
VYLPGCLNQS CGSSCCQPCC RPACCETTCC RTTCFQPTCV TSCCQPACC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006070 Genomic DNA. No translation available.
CCDSCCDS59287.1.
RefSeqNP_001264261.1. NM_001277332.1.

3D structure databases

ProteinModelPortalA8MTY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000375149.

Proteomic databases

PaxDbA8MTY7.
PRIDEA8MTY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391354; ENSP00000375149; ENSG00000180386.
ENST00000573531; ENSP00000460369; ENSG00000262221.
GeneID100505724.
KEGGhsa:100505724.
UCSCuc031rah.1. human.

Organism-specific databases

CTD100505724.
GeneCardsGC17P039431.
HGNCHGNC:18915. KRTAP9-7.
HPAHPA042482.
neXtProtNX_A8MTY7.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG4726.
HOGENOMHOG000234030.
InParanoidA8MTY7.
OMACRRACYH.
OrthoDBEOG7WMCNT.
PhylomeDBA8MTY7.
TreeFamTF351356.

Gene expression databases

GenevestigatorA8MTY7.

Family and domain databases

InterProIPR002494. KAP.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
PfamPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi100505724.
NextBio34053914.
PROA8MTY7.

Entry information

Entry nameKRA97_HUMAN
AccessionPrimary (citable) accession number: A8MTY7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM