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Protein

Keratin-associated protein 9-7

Gene

KRTAP9-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:G66-33788-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-7
Gene namesi
Name:KRTAP9-7
Synonyms:KAP9.7, KRTAP9.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18915. KRTAP9-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180386.
ENSG00000262221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322591 – 169Keratin-associated protein 9-7Add BLAST169

Proteomic databases

PaxDbiA8MTY7.
PRIDEiA8MTY7.

Expressioni

Organism-specific databases

HPAiCAB016268.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

BioGridi124441. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA8MTY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1215
Repeati13 – 1725
Repeati32 – 3635
Repeati37 – 4145
Repeati46 – 5055
Repeati51 – 5565
Repeati56 – 6075
Repeati61 – 6585
Repeati75 – 7995
Repeati80 – 84105
Repeati85 – 89115
Repeati90 – 94125
Repeati100 – 104135
Repeati139 – 143145
Repeati144 – 148155
Repeati149 – 153165
Repeati163 – 167175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 16717 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]Add BLAST160

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiA8MTY7.
OMAiCRTACCQ.
PhylomeDBiA8MTY7.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MTY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT
60 70 80 90 100
CCQNTCCRTT CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC
110 120 130 140 150
CQPSSCAPIY CRRTCYHPTS VYLPGCLNQS CGSSCCQPCC RPACCETTCC
160
RTTCFQPTCV TSCCQPACC
Length:169
Mass (Da):17,793
Last modified:December 4, 2007 - v1
Checksum:i17320FA5E5159495
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04299523T → I.Corresponds to variant rs4890107dbSNPEnsembl.1
Natural variantiVAR_042996130S → N.Corresponds to variant rs12948628dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS59287.1.
RefSeqiNP_001264261.1. NM_001277332.1.

Genome annotation databases

EnsembliENST00000391354; ENSP00000375149; ENSG00000180386.
ENST00000573531; ENSP00000460369; ENSG00000262221.
GeneIDi100505724.
KEGGihsa:100505724.
UCSCiuc031rah.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS59287.1.
RefSeqiNP_001264261.1. NM_001277332.1.

3D structure databases

ProteinModelPortaliA8MTY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124441. 1 interactor.

Proteomic databases

PaxDbiA8MTY7.
PRIDEiA8MTY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391354; ENSP00000375149; ENSG00000180386.
ENST00000573531; ENSP00000460369; ENSG00000262221.
GeneIDi100505724.
KEGGihsa:100505724.
UCSCiuc031rah.2. human.

Organism-specific databases

CTDi100505724.
GeneCardsiKRTAP9-7.
HGNCiHGNC:18915. KRTAP9-7.
HPAiCAB016268.
neXtProtiNX_A8MTY7.
OpenTargetsiENSG00000180386.
ENSG00000262221.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JE2D. Eukaryota.
ENOG41118YY. LUCA.
GeneTreeiENSGT00810000125514.
HOGENOMiHOG000234030.
InParanoidiA8MTY7.
OMAiCRTACCQ.
PhylomeDBiA8MTY7.
TreeFamiTF351356.

Enzyme and pathway databases

BioCyciZFISH:G66-33788-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii100505724.
PROiA8MTY7.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA97_HUMAN
AccessioniPrimary (citable) accession number: A8MTY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.