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A8MTY7

- KRA97_HUMAN

UniProt

A8MTY7 - KRA97_HUMAN

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Protein
Keratin-associated protein 9-7
Gene
KRTAP9-7, KAP9.7, KRTAP9.7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-7
Gene namesi
Synonyms:KAP9.7, KRTAP9.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18915. KRTAP9-7.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Keratin-associated protein 9-7
PRO_0000332259Add
BLAST

Proteomic databases

PaxDbiA8MTY7.
PRIDEiA8MTY7.

Expressioni

Gene expression databases

GenevestigatoriA8MTY7.

Organism-specific databases

HPAiHPA042482.

Interactioni

Subunit structurei

Interacts with hair keratins By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000375149.

Structurei

3D structure databases

ProteinModelPortaliA8MTY7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 1251
Repeati13 – 1752
Repeati32 – 3653
Repeati37 – 4154
Repeati46 – 5055
Repeati51 – 5556
Repeati56 – 6057
Repeati61 – 6558
Repeati75 – 7959
Repeati80 – 84510
Repeati85 – 89511
Repeati90 – 94512
Repeati100 – 104513
Repeati139 – 143514
Repeati144 – 148515
Repeati149 – 153516
Repeati163 – 167517

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 16716017 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]
Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 9 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726.
HOGENOMiHOG000234030.
InParanoidiA8MTY7.
OMAiCRRACYH.
OrthoDBiEOG7WMCNT.
PhylomeDBiA8MTY7.
TreeFamiTF351356.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiPF13885. Keratin_B2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MTY7-1 [UniParc]FASTAAdd to Basket

« Hide

MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT    50
CCQNTCCRTT CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC 100
CQPSSCAPIY CRRTCYHPTS VYLPGCLNQS CGSSCCQPCC RPACCETTCC 150
RTTCFQPTCV TSCCQPACC 169
Length:169
Mass (Da):17,793
Last modified:December 4, 2007 - v1
Checksum:i17320FA5E5159495
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231T → I.
Corresponds to variant rs4890107 [ dbSNP | Ensembl ].
VAR_042995
Natural varianti130 – 1301S → N.
Corresponds to variant rs12948628 [ dbSNP | Ensembl ].
VAR_042996

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSiCCDS59287.1.
RefSeqiNP_001264261.1. NM_001277332.1.

Genome annotation databases

EnsembliENST00000391354; ENSP00000375149; ENSG00000180386.
ENST00000573531; ENSP00000460369; ENSG00000262221.
GeneIDi100505724.
KEGGihsa:100505724.
UCSCiuc031rah.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006070 Genomic DNA. No translation available.
CCDSi CCDS59287.1.
RefSeqi NP_001264261.1. NM_001277332.1.

3D structure databases

ProteinModelPortali A8MTY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375149.

Proteomic databases

PaxDbi A8MTY7.
PRIDEi A8MTY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391354 ; ENSP00000375149 ; ENSG00000180386 .
ENST00000573531 ; ENSP00000460369 ; ENSG00000262221 .
GeneIDi 100505724.
KEGGi hsa:100505724.
UCSCi uc031rah.1. human.

Organism-specific databases

CTDi 100505724.
GeneCardsi GC17P039431.
HGNCi HGNC:18915. KRTAP9-7.
HPAi HPA042482.
neXtProti NX_A8MTY7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi KOG4726.
HOGENOMi HOG000234030.
InParanoidi A8MTY7.
OMAi CRRACYH.
OrthoDBi EOG7WMCNT.
PhylomeDBi A8MTY7.
TreeFami TF351356.

Miscellaneous databases

GenomeRNAii 100505724.
NextBioi 34053914.
PROi A8MTY7.

Gene expression databases

Genevestigatori A8MTY7.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
Pfami PF13885. Keratin_B2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKRA97_HUMAN
AccessioniPrimary (citable) accession number: A8MTY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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