A8MTY7 (KRA97_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 9-7

Gene names

Name:	KRTAP9-7
Synonyms:	KAP9.7, KRTAP9.7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins By similarity.
Subunit structure	Interacts with hair keratins By similarity.
Sequence similarities	Belongs to the KRTAP type 9 family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Keratin-associated protein 9-7		PRO_0000332259
Regions
	Repeat	8 – 12	5	1
	Repeat	13 – 17	5	2
	Repeat	32 – 36	5	3
	Repeat	37 – 41	5	4
	Repeat	46 – 50	5	5
	Repeat	51 – 55	5	6
	Repeat	56 – 60	5	7
	Repeat	61 – 65	5	8
	Repeat	75 – 79	5	9
	Repeat	80 – 84	5	10
	Repeat	85 – 89	5	11
	Repeat	90 – 94	5	12
	Repeat	100 – 104	5	13
	Repeat	139 – 143	5	14
	Repeat	144 – 148	5	15
	Repeat	149 – 153	5	16
	Repeat	163 – 167	5	17
	Region	8 – 167	160	17 X 5 AA repeats of C-C-[VGSREQH]-[SQTPN]-[STPAI]
Natural variations
	Natural variant	23	1	T → I. Corresponds to variant rs4890107 [ dbSNP | Ensembl ].		VAR_042995
	Natural variant	130	1	S → N. Corresponds to variant rs12948628 [ dbSNP | Ensembl ].		VAR_042996

Sequences

	Sequence		Length	Mass (Da)
	A8MTY7 [UniParc]. Last modified December 4, 2007. Version 1. Checksum: 17320FA5E5159495	FASTA	169	17,793
	10 20 30 40 50 60 MTHCCSPCCQ PTCCRTTCWK PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT 70 80 90 100 110 120 CCQPTCVTSC CQPSCCSTPC CQPICCGSSC CGQTSCGSSC CQPSSCAPIY CRRTCYHPTS 130 140 150 160 VYLPGCLNQS CGSSCCQPCC RPACCETTCC RTTCFQPTCV TSCCQPACC

References

[1]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC006070 Genomic DNA. No translation available.
IPI	IPI00787309.
RefSeq	XP_003118786.1. XM_003118738.1. XP_003119715.1. XM_003119667.1. XP_003846531.1. XM_003846483.1.
3D structure databases
ProteinModelPortal	A8MTY7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000375149.
Proteomic databases
PaxDb	A8MTY7.
PRIDE	A8MTY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391354; ENSP00000375149; ENSG00000180386. ENST00000573531; ENSP00000460369; ENSG00000262221.
GeneID	100505724.
KEGG	hsa:100505724.
Organism-specific databases
CTD	100505724.
GeneCards	GC17P039431.
HGNC	HGNC:18915. KRTAP9-7.
neXtProt	NX_A8MTY7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG4726.
HOGENOM	HOG000234030.
InParanoid	A8MTY7.
OMA	SESSCCG.
OrthoDB	EOG4MKNJ2.
Gene expression databases
Genevestigator	A8MTY7.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	100505724.
NextBio	34053914.

Entry information

Entry name

KRA97_HUMAN

Accession

Primary (citable) accession number: A8MTY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 4, 2007
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.