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Protein

Zinc finger protein 724

Gene

ZNF724

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33505-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 724Curated
Gene namesi
Name:ZNF724Imported
Synonyms:ZNF724PImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32460. ZNF724.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322831 – 619Zinc finger protein 724Add BLAST619

Proteomic databases

MaxQBiA8MTY0.
PaxDbiA8MTY0.
B4DVU0.
PRIDEiA8MTY0.

PTM databases

iPTMnetiA8MTY0.
PhosphoSitePlusiA8MTY0.

Expressioni

Gene expression databases

BgeeiENSG00000196081.
ExpressionAtlasiA8MTY0. baseline and differential.

Organism-specific databases

HPAiCAB015400.
CAB034021.

Interactioni

Protein-protein interaction databases

IntActiA8MTY0. 1 interactor.
STRINGi9606.ENSP00000413411.

Structurei

3D structure databases

ProteinModelPortaliA8MTY0.
SMRiA8MTY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MTY0.
OMAiYVKDFHK.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MTY0.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MTY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLTFMDVA IEFSVEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQGK EPWNMERHEM VAKPPGMCCY FAQDLRPEQS IKASLQRIIL
110 120 130 140 150
RKYEKCGHHN LQLKKGYKSV DEYKVHKGSY NGFNQCLTTT QSKIFQCDKY
160 170 180 190 200
VKDFHKFSNS NRHKTEKNPF KCKECGKSFC VLSHLTQHKR IHTTVNSYKL
210 220 230 240 250
EECGKAFNVS STLSQHKRIH TGQKHYKCEE CGIAFNKSSH LNTHKIIHTG
260 270 280 290 300
EKSYKREECG KAFNISSHLT THKIIHTGEN AYKCKECGKA FNQSSTLTRH
310 320 330 340 350
KIIHAGEKPY ICEHCGRAFN QSSNLTKHKR IHTGDKPYKC EECGKAFNVS
360 370 380 390 400
STLTQHKRIH TGEKPYKCEE CGKAFNVSST LTQHKRIHTG EKPYKCEECG
410 420 430 440 450
KAFNTSSHLT THKRIHTGEK PYKCEECGKA FNQFSQLTTH KIIHTGEKPY
460 470 480 490 500
KCKECGKAFK RSSNLTEHRI IHTGEKPYKC EECGKAFNLS SHLTTHKKIH
510 520 530 540 550
TGEKPYKCKE CGKAFNQSST LARHKIIHAG EKPYKCEECG KAFYQYSNLT
560 570 580 590 600
QHKIIHTGEK PYKCEECGKA FNWSSTLTKH KVIHTGEKPY KCKECGKAFN
610
QCSNLTTHKK IHAVEKSDK
Length:619
Mass (Da):71,172
Last modified:December 15, 2009 - v3
Checksum:i7E1F76A81721C9B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti525K → R in BAG62802 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301230 mRNA. Translation: BAG62802.1.
AC092329 Genomic DNA. No translation available.
UniGeneiHs.675814.

Genome annotation databases

EnsembliENST00000418100; ENSP00000413411; ENSG00000196081.
UCSCiuc060wjr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301230 mRNA. Translation: BAG62802.1.
AC092329 Genomic DNA. No translation available.
UniGeneiHs.675814.

3D structure databases

ProteinModelPortaliA8MTY0.
SMRiA8MTY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA8MTY0. 1 interactor.
STRINGi9606.ENSP00000413411.

PTM databases

iPTMnetiA8MTY0.
PhosphoSitePlusiA8MTY0.

Proteomic databases

MaxQBiA8MTY0.
PaxDbiA8MTY0.
B4DVU0.
PRIDEiA8MTY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418100; ENSP00000413411; ENSG00000196081.
UCSCiuc060wjr.1. human.

Organism-specific databases

GeneCardsiZNF724P.
HGNCiHGNC:32460. ZNF724.
HPAiCAB015400.
CAB034021.
neXtProtiNX_A8MTY0.
OpenTargetsiENSG00000196081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA8MTY0.
OMAiYVKDFHK.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MTY0.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:G66-33505-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Gene expression databases

BgeeiENSG00000196081.
ExpressionAtlasiA8MTY0. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN724_HUMAN
AccessioniPrimary (citable) accession number: A8MTY0
Secondary accession number(s): B4DVU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2009
Last modified: November 2, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.