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Protein

Homeobox protein notochord

Gene

NOTO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 215HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein notochord
Gene namesi
Name:NOTO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000214513.3
HGNCiHGNC:31839 NOTO
neXtProtiNX_A8MTQ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214513
PharmGKBiPA134895171

Polymorphism and mutation databases

BioMutaiNOTO

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432231 – 251Homeobox protein notochordAdd BLAST251

Proteomic databases

PaxDbiA8MTQ0
PRIDEiA8MTQ0

PTM databases

iPTMnetiA8MTQ0
PhosphoSitePlusiA8MTQ0

Expressioni

Gene expression databases

BgeeiENSG00000214513
CleanExiHS_NOTO

Organism-specific databases

HPAiHPA034660

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381486

Structurei

3D structure databases

ProteinModelPortaliA8MTQ0
SMRiA8MTQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 68Pro-richAdd BLAST67

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843 Eukaryota
ENOG4111SRW LUCA
GeneTreeiENSGT00910000144043
HOGENOMiHOG000082431
HOVERGENiHBG108196
InParanoidiA8MTQ0
OMAiYPVPGPR
OrthoDBiEOG091G0M18
PhylomeDBiA8MTQ0
TreeFamiTF326858

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8MTQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPRPRGSP PPAPSGSRVR PPRSGRSPAP RSPTGPNTPR APGRFESPFS
60 70 80 90 100
VEAILARPDP CAPAASQPSG SACVHPAFWT AASLCATGGL PWACPTSWLP
110 120 130 140 150
AYLSVGFYPV PGPRVAPVCG LLGFGVTGLE LAHCSGLWAF PDWAPTEDLQ
160 170 180 190 200
DTERQQKRVR TMFNLEQLEE LEKVFAKQHN LVGKKRAQLA ARLKLTENQV
210 220 230 240 250
RVWFQNRRVK YQKQQKLRAA VTSAEAASLD EPSSSSIASI QSDDAESGVD

G
Length:251
Mass (Da):27,003
Last modified:July 1, 2008 - v2
Checksum:i56BBB3E0E6B5B092
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0593535R → T. Corresponds to variant dbSNP:rs1864492Ensembl.1
Natural variantiVAR_059354164N → K. Corresponds to variant dbSNP:rs13418681Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295936 mRNA Translation: BAG58721.1
AK316410 mRNA Translation: BAH14781.1
AC010913 Genomic DNA No translation available.
CCDSiCCDS46335.1
RefSeqiNP_001127934.1, NM_001134462.1
UniGeneiHs.694384

Genome annotation databases

EnsembliENST00000398468; ENSP00000381486; ENSG00000214513
GeneIDi344022
KEGGihsa:344022
UCSCiuc010yrd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOTO_HUMAN
AccessioniPrimary (citable) accession number: A8MTQ0
Secondary accession number(s): B4DJ59, B7ZAU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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