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A8MTL3

- R212B_HUMAN

UniProt

A8MTL3 - R212B_HUMAN

Protein

RING finger protein 212B

Gene

RNF212B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 4035RING-typeAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 212B
    Gene namesi
    Name:RNF212B
    Synonyms:C14orf164
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20438. RNF212B.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300RING finger protein 212BPRO_0000349181Add
    BLAST

    Proteomic databases

    PaxDbiA8MTL3.
    PRIDEiA8MTL3.

    PTM databases

    PhosphoSiteiA8MTL3.

    Expressioni

    Gene expression databases

    ArrayExpressiA8MTL3.
    BgeeiA8MTL3.
    GenevestigatoriA8MTL3.

    Organism-specific databases

    HPAiHPA053574.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MTL3.
    SMRiA8MTL3. Positions 4-46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili87 – 12438Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 4035RING-typeAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG122049.
    HOGENOMiHOG000155629.
    HOVERGENiHBG097206.
    InParanoidiA8MTL3.
    OMAiYQQRQMG.
    OrthoDBiEOG776SRM.
    PhylomeDBiA8MTL3.
    TreeFamiTF319600.

    Family and domain databases

    InterProiIPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF14634. zf-RING_5. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MTL3-1 [UniParc]FASTAAdd to Basket

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    MDWFHCNQCF RKDGAHFFVT SCGHIFCKKC VTLEKCAVCG TACKHLALSD    50
    NLKPQEKMFF KSPVETALQY FSHISQVWSF QKKQTDLLIA FYKHRITKLE 100
    TAMQEAQQAL VSQDKELSVL RKENGELKKF LAILKESPSR YQGSRSITPR 150
    PVGITSPSQS VTPRPSFQHS SQVVSRSSSA ESIPYREAGF GSLGQGGRGL 200
    QGRRTPRDSY NETPSPASTH SLSYRTSSAS SGQGIFSFRP SPNGHSGHTR 250
    VLTPNNFAQR ESTTTLESLP SFQLPVLQTL YQQRRHMGLP SGREAWTTSR 300
    Length:300
    Mass (Da):33,570
    Last modified:December 4, 2007 - v1
    Checksum:iA064DB5E3DCE0DFE
    GO

    Sequence cautioni

    The sequence EB710205 differs from that shown. Reason: Frameshift at position 40.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271S → T in EB710205. 1 PublicationCurated
    Sequence conflicti234 – 2341G → E in EB710205. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117258 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66180.1.
    EB710205 mRNA. No translation available.
    CCDSiCCDS61401.1.
    RefSeqiNP_001269251.1. NM_001282322.1.

    Genome annotation databases

    EnsembliENST00000399910; ENSP00000382794; ENSG00000215277.
    ENST00000430154; ENSP00000397830; ENSG00000215277.
    GeneIDi100507650.
    KEGGihsa:100507650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117258 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66180.1 .
    EB710205 mRNA. No translation available.
    CCDSi CCDS61401.1.
    RefSeqi NP_001269251.1. NM_001282322.1.

    3D structure databases

    ProteinModelPortali A8MTL3.
    SMRi A8MTL3. Positions 4-46.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A8MTL3.

    Proteomic databases

    PaxDbi A8MTL3.
    PRIDEi A8MTL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399910 ; ENSP00000382794 ; ENSG00000215277 .
    ENST00000430154 ; ENSP00000397830 ; ENSG00000215277 .
    GeneIDi 100507650.
    KEGGi hsa:100507650.

    Organism-specific databases

    CTDi 100507650.
    GeneCardsi GC14P023657.
    HGNCi HGNC:20438. RNF212B.
    HPAi HPA053574.
    neXtProti NX_A8MTL3.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122049.
    HOGENOMi HOG000155629.
    HOVERGENi HBG097206.
    InParanoidi A8MTL3.
    OMAi YQQRQMG.
    OrthoDBi EOG776SRM.
    PhylomeDBi A8MTL3.
    TreeFami TF319600.

    Gene expression databases

    ArrayExpressi A8MTL3.
    Bgeei A8MTL3.
    Genevestigatori A8MTL3.

    Family and domain databases

    InterProi IPR001841. Znf_RING.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF14634. zf-RING_5. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
      Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-250.

    Entry informationi

    Entry nameiR212B_HUMAN
    AccessioniPrimary (citable) accession number: A8MTL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3