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Protein

RING finger protein 212B

Gene

RNF212B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 4035RING-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 212B
Gene namesi
Name:RNF212B
Synonyms:C14orf164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20438. RNF212B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300RING finger protein 212BPRO_0000349181Add
BLAST

Proteomic databases

PaxDbiA8MTL3.
PRIDEiA8MTL3.

PTM databases

PhosphoSiteiA8MTL3.

Expressioni

Gene expression databases

BgeeiA8MTL3.
ExpressionAtlasiA8MTL3. baseline and differential.
GenevestigatoriA8MTL3.

Organism-specific databases

HPAiHPA053574.

Structurei

3D structure databases

ProteinModelPortaliA8MTL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 12438Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 4035RING-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG122049.
GeneTreeiENSGT00740000115581.
HOGENOMiHOG000155629.
HOVERGENiHBG097206.
InParanoidiA8MTL3.
OMAiPRDSYNE.
OrthoDBiEOG776SRM.
PhylomeDBiA8MTL3.
TreeFamiTF319600.

Family and domain databases

InterProiIPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF14634. zf-RING_5. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MTL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWFHCNQCF RKDGAHFFVT SCGHIFCKKC VTLEKCAVCG TACKHLALSD
60 70 80 90 100
NLKPQEKMFF KSPVETALQY FSHISQVWSF QKKQTDLLIA FYKHRITKLE
110 120 130 140 150
TAMQEAQQAL VSQDKELSVL RKENGELKKF LAILKESPSR YQGSRSITPR
160 170 180 190 200
PVGITSPSQS VTPRPSFQHS SQVVSRSSSA ESIPYREAGF GSLGQGGRGL
210 220 230 240 250
QGRRTPRDSY NETPSPASTH SLSYRTSSAS SGQGIFSFRP SPNGHSGHTR
260 270 280 290 300
VLTPNNFAQR ESTTTLESLP SFQLPVLQTL YQQRRHMGLP SGREAWTTSR
Length:300
Mass (Da):33,570
Last modified:December 4, 2007 - v1
Checksum:iA064DB5E3DCE0DFE
GO

Sequence cautioni

The sequence EB710205 differs from that shown. Reason: Frameshift at position 40. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271S → T in EB710205 (Ref. 3) Curated
Sequence conflicti234 – 2341G → E in EB710205 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117258 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66180.1.
EB710205 mRNA. No translation available.
CCDSiCCDS61401.1.
RefSeqiNP_001269251.1. NM_001282322.1.

Genome annotation databases

EnsembliENST00000399910; ENSP00000382794; ENSG00000215277.
ENST00000430154; ENSP00000397830; ENSG00000215277.
GeneIDi100507650.
KEGGihsa:100507650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117258 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66180.1.
EB710205 mRNA. No translation available.
CCDSiCCDS61401.1.
RefSeqiNP_001269251.1. NM_001282322.1.

3D structure databases

ProteinModelPortaliA8MTL3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA8MTL3.

Proteomic databases

PaxDbiA8MTL3.
PRIDEiA8MTL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399910; ENSP00000382794; ENSG00000215277.
ENST00000430154; ENSP00000397830; ENSG00000215277.
GeneIDi100507650.
KEGGihsa:100507650.

Organism-specific databases

CTDi100507650.
GeneCardsiGC14P023786.
HGNCiHGNC:20438. RNF212B.
HPAiHPA053574.
neXtProtiNX_A8MTL3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG122049.
GeneTreeiENSGT00740000115581.
HOGENOMiHOG000155629.
HOVERGENiHBG097206.
InParanoidiA8MTL3.
OMAiPRDSYNE.
OrthoDBiEOG776SRM.
PhylomeDBiA8MTL3.
TreeFamiTF319600.

Gene expression databases

BgeeiA8MTL3.
ExpressionAtlasiA8MTL3. baseline and differential.
GenevestigatoriA8MTL3.

Family and domain databases

InterProiIPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF14634. zf-RING_5. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-250.

Entry informationi

Entry nameiR212B_HUMAN
AccessioniPrimary (citable) accession number: A8MTL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.