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A8MTJ6

- FOXI3_HUMAN

UniProt

A8MTJ6 - FOXI3_HUMAN

Protein

Forkhead box protein I3

Gene

FOXI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 3 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Possible transcriptional factor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi145 – 23995Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein I3
    Gene namesi
    Name:FOXI3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:35123. FOXI3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164720107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Forkhead box protein I3PRO_0000341225Add
    BLAST

    Proteomic databases

    PRIDEiA8MTJ6.

    Expressioni

    Gene expression databases

    GenevestigatoriA8MTJ6.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MTJ6.
    SMRiA8MTJ6. Positions 143-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 126112Pro-richAdd
    BLAST
    Compositional biasi21 – 124104Ala-richAdd
    BLAST
    Compositional biasi242 – 400159Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG067944.
    InParanoidiA8MTJ6.
    KOiK09401.
    PhylomeDBiA8MTJ6.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8MTJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALYCGDNFG VYSQPGLPPP AATAAAPGAP PAARAPYGLA DYAAPPAAAA    50
    NPYLWLNGPG VGGPPSAAAA AAAAYLGAPP PPPPPGAAAG PFLQPPPAAG 100
    TFGCSQRPFA QPAPAAPASP AAPAGPGELG WLSMASREDL MKMVRPPYSY 150
    SALIAMAIQS APERKLTLSH IYQFVADSFP FYQRSKAGWQ NSIRHNLSLN 200
    DCFKKVPRDE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR RSEASNGSTV 250
    AAGTSKSEEG LSSGLGSGVG GKPEEESPST LLRPSHSPEP PEGTKSTASS 300
    PGGPMLTSTP CLNTFFSSLS SLSVSSSVST QRALPGSRHL GIQGAQLPSS 350
    GVFSPTSISE ASADTLQLSN STSNSTGQRS SYYSPFPAST SGGQSSPFSS 400
    PFHNFSMVNS LIYPREGSEV 420
    Length:420
    Mass (Da):43,326
    Last modified:March 24, 2009 - v3
    Checksum:i4531A9DA62B322E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012671 Genomic DNA. No translation available.
    BN001221 Genomic DNA. Translation: CAR63508.1.
    BN001222 mRNA. Translation: CAR63509.1.
    RefSeqiNP_001129121.1. NM_001135649.1.
    UniGeneiHs.716722.

    Genome annotation databases

    GeneIDi344167.
    KEGGihsa:344167.
    UCSCiuc010ytq.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012671 Genomic DNA. No translation available.
    BN001221 Genomic DNA. Translation: CAR63508.1 .
    BN001222 mRNA. Translation: CAR63509.1 .
    RefSeqi NP_001129121.1. NM_001135649.1.
    UniGenei Hs.716722.

    3D structure databases

    ProteinModelPortali A8MTJ6.
    SMRi A8MTJ6. Positions 143-234.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A8MTJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 344167.
    KEGGi hsa:344167.
    UCSCi uc010ytq.1. human.

    Organism-specific databases

    CTDi 344167.
    GeneCardsi GC02M088747.
    HGNCi HGNC:35123. FOXI3.
    MIMi 612351. gene.
    neXtProti NX_A8MTJ6.
    PharmGKBi PA164720107.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG067944.
    InParanoidi A8MTJ6.
    KOi K09401.
    PhylomeDBi A8MTJ6.

    Miscellaneous databases

    GenomeRNAii 344167.
    NextBioi 98650.
    PROi A8MTJ6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A8MTJ6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiFOXI3_HUMAN
    AccessioniPrimary (citable) accession number: A8MTJ6
    Secondary accession number(s): B5RI09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 55 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3