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A8MTJ6

- FOXI3_HUMAN

UniProt

A8MTJ6 - FOXI3_HUMAN

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Protein

Forkhead box protein I3

Gene

FOXI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Possible transcriptional factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi145 – 23995Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I3
Gene namesi
Name:FOXI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:35123. FOXI3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Forkhead box protein I3PRO_0000341225Add
BLAST

Proteomic databases

PRIDEiA8MTJ6.

Expressioni

Gene expression databases

GenevestigatoriA8MTJ6.

Structurei

3D structure databases

ProteinModelPortaliA8MTJ6.
SMRiA8MTJ6. Positions 143-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 126112Pro-richAdd
BLAST
Compositional biasi21 – 124104Ala-richAdd
BLAST
Compositional biasi242 – 400159Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG067944.
InParanoidiA8MTJ6.
KOiK09401.
PhylomeDBiA8MTJ6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MTJ6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALYCGDNFG VYSQPGLPPP AATAAAPGAP PAARAPYGLA DYAAPPAAAA
60 70 80 90 100
NPYLWLNGPG VGGPPSAAAA AAAAYLGAPP PPPPPGAAAG PFLQPPPAAG
110 120 130 140 150
TFGCSQRPFA QPAPAAPASP AAPAGPGELG WLSMASREDL MKMVRPPYSY
160 170 180 190 200
SALIAMAIQS APERKLTLSH IYQFVADSFP FYQRSKAGWQ NSIRHNLSLN
210 220 230 240 250
DCFKKVPRDE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR RSEASNGSTV
260 270 280 290 300
AAGTSKSEEG LSSGLGSGVG GKPEEESPST LLRPSHSPEP PEGTKSTASS
310 320 330 340 350
PGGPMLTSTP CLNTFFSSLS SLSVSSSVST QRALPGSRHL GIQGAQLPSS
360 370 380 390 400
GVFSPTSISE ASADTLQLSN STSNSTGQRS SYYSPFPAST SGGQSSPFSS
410 420
PFHNFSMVNS LIYPREGSEV
Length:420
Mass (Da):43,326
Last modified:March 24, 2009 - v3
Checksum:i4531A9DA62B322E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012671 Genomic DNA. No translation available.
BN001221 Genomic DNA. Translation: CAR63508.1.
BN001222 mRNA. Translation: CAR63509.1.
RefSeqiNP_001129121.1. NM_001135649.1.
UniGeneiHs.716722.

Genome annotation databases

GeneIDi344167.
KEGGihsa:344167.
UCSCiuc010ytq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012671 Genomic DNA. No translation available.
BN001221 Genomic DNA. Translation: CAR63508.1 .
BN001222 mRNA. Translation: CAR63509.1 .
RefSeqi NP_001129121.1. NM_001135649.1.
UniGenei Hs.716722.

3D structure databases

ProteinModelPortali A8MTJ6.
SMRi A8MTJ6. Positions 143-234.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A8MTJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 344167.
KEGGi hsa:344167.
UCSCi uc010ytq.1. human.

Organism-specific databases

CTDi 344167.
GeneCardsi GC02M088747.
HGNCi HGNC:35123. FOXI3.
MIMi 612351. gene.
neXtProti NX_A8MTJ6.
PharmGKBi PA164720107.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG067944.
InParanoidi A8MTJ6.
KOi K09401.
PhylomeDBi A8MTJ6.

Miscellaneous databases

GenomeRNAii 344167.
NextBioi 98650.
PROi A8MTJ6.
SOURCEi Search...

Gene expression databases

Genevestigatori A8MTJ6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFOXI3_HUMAN
AccessioniPrimary (citable) accession number: A8MTJ6
Secondary accession number(s): B5RI09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3