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A8MTJ6 (FOXI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein I3
Gene names
Name:FOXI3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible transcriptional factor By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Forkhead box protein I3
PRO_0000341225

Regions

DNA binding145 – 23995Fork-head
Compositional bias15 – 126112Pro-rich
Compositional bias21 – 124104Ala-rich
Compositional bias242 – 400159Ser-rich

Sequences

Sequence LengthMass (Da)Tools
A8MTJ6 [UniParc].

Last modified March 24, 2009. Version 3.
Checksum: 4531A9DA62B322E7

FASTA42043,326
        10         20         30         40         50         60 
MALYCGDNFG VYSQPGLPPP AATAAAPGAP PAARAPYGLA DYAAPPAAAA NPYLWLNGPG 

        70         80         90        100        110        120 
VGGPPSAAAA AAAAYLGAPP PPPPPGAAAG PFLQPPPAAG TFGCSQRPFA QPAPAAPASP 

       130        140        150        160        170        180 
AAPAGPGELG WLSMASREDL MKMVRPPYSY SALIAMAIQS APERKLTLSH IYQFVADSFP 

       190        200        210        220        230        240 
FYQRSKAGWQ NSIRHNLSLN DCFKKVPRDE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR 

       250        260        270        280        290        300 
RSEASNGSTV AAGTSKSEEG LSSGLGSGVG GKPEEESPST LLRPSHSPEP PEGTKSTASS 

       310        320        330        340        350        360 
PGGPMLTSTP CLNTFFSSLS SLSVSSSVST QRALPGSRHL GIQGAQLPSS GVFSPTSISE 

       370        380        390        400        410        420 
ASADTLQLSN STSNSTGQRS SYYSPFPAST SGGQSSPFSS PFHNFSMVNS LIYPREGSEV 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"A mutation in hairless dogs implicates FOXI3 in ectodermal development."
Droegemueller C., Karlsson E.K., Hytoenen M.K., Perloski M., Dolf G., Sainio K., Lohi H., Lindblad-Toh K., Leeb T.
Science 321:1462-1462(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC012671 Genomic DNA. No translation available.
BN001221 Genomic DNA. Translation: CAR63508.1.
BN001222 mRNA. Translation: CAR63509.1.
RefSeqNP_001129121.1. NM_001135649.1.
UniGeneHs.716722.

3D structure databases

ProteinModelPortalA8MTJ6.
SMRA8MTJ6. Positions 143-234.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA8MTJ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID344167.
KEGGhsa:344167.
UCSCuc010ytq.1. human.

Organism-specific databases

CTD344167.
GeneCardsGC02M088747.
HGNCHGNC:35123. FOXI3.
MIM612351. gene.
neXtProtNX_A8MTJ6.
PharmGKBPA164720107.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG067944.
InParanoidA8MTJ6.
KOK09401.
PhylomeDBA8MTJ6.

Gene expression databases

GenevestigatorA8MTJ6.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi344167.
NextBio98650.
PROA8MTJ6.
SOURCESearch...

Entry information

Entry nameFOXI3_HUMAN
AccessionPrimary (citable) accession number: A8MTJ6
Secondary accession number(s): B5RI09
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM