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Protein

Carcinoembryonic antigen-related cell adhesion molecule 18

Gene

CEACAM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 18
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31949. CEACAM18.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 384354Carcinoembryonic antigen-related cell adhesion molecule 18PRO_0000339378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 296PROSITE-ProRule annotation
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiA8MTB9.
PaxDbiA8MTB9.
PeptideAtlasiA8MTB9.
PRIDEiA8MTB9.

PTM databases

PhosphoSiteiA8MTB9.

Expressioni

Gene expression databases

CleanExiHS_CEACAM18.

Organism-specific databases

HPAiHPA059487.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000402203.

Structurei

3D structure databases

ProteinModelPortaliA8MTB9.
SMRiA8MTB9. Positions 49-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 31488Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410JB7I. Eukaryota.
ENOG4111BYI. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000111529.
HOVERGENiHBG107644.
InParanoidiA8MTB9.
OMAiSQVEMEC.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MTB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD
60 70 80 90 100
KVPEDVQEYS WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL
110 120 130 140 150
LIRPTALNDT GNYTVRVVAG NETQRATGWL EVLELGSNLG ISVNASSLVE
160 170 180 190 200
NMDSVAADCL TNVTNITWYV NDVPTSSSDR MTISPDGKTL VILRVSRYDR
210 220 230 240 250
TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN GIVTAEIGSQ
260 270 280 290 300
VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN
310 320 330 340 350
PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW
360 370 380
SPDPCSDQPL LNQDKSGSMS VHPRPEDKTR RASR
Length:384
Mass (Da):43,320
Last modified:May 1, 2013 - v4
Checksum:iB7D3DDB65B282C3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti160 – 1601L → H.
Corresponds to variant rs8106673 [ dbSNP | Ensembl ].
VAR_043976
Natural varianti161 – 1611T → A.
Corresponds to variant rs12610545 [ dbSNP | Ensembl ].
VAR_043977

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020914 Genomic DNA. No translation available.
UniGeneiHs.653111.

Genome annotation databases

EnsembliENST00000396477; ENSP00000379738; ENSG00000213822.
UCSCiuc061bxs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020914 Genomic DNA. No translation available.
UniGeneiHs.653111.

3D structure databases

ProteinModelPortaliA8MTB9.
SMRiA8MTB9. Positions 49-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402203.

PTM databases

PhosphoSiteiA8MTB9.

Proteomic databases

EPDiA8MTB9.
PaxDbiA8MTB9.
PeptideAtlasiA8MTB9.
PRIDEiA8MTB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396477; ENSP00000379738; ENSG00000213822.
UCSCiuc061bxs.1. human.

Organism-specific databases

GeneCardsiCEACAM18.
HGNCiHGNC:31949. CEACAM18.
HPAiHPA059487.
neXtProtiNX_A8MTB9.
PharmGKBiPA142672132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB7I. Eukaryota.
ENOG4111BYI. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000111529.
HOVERGENiHBG107644.
InParanoidiA8MTB9.
OMAiSQVEMEC.
TreeFamiTF336859.

Miscellaneous databases

PROiA8MTB9.

Gene expression databases

CleanExiHS_CEACAM18.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCEA18_HUMAN
AccessioniPrimary (citable) accession number: A8MTB9
Secondary accession number(s): C9JN24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2013
Last modified: July 6, 2016
This is version 67 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.