A8MTB9 (CEA18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 18

Gene names

Name:

CEACAM18

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 384	354	Carcinoembryonic antigen-related cell adhesion molecule 18		PRO_0000339378
Regions
	Domain	227 – 314	88	Ig-like C2-type
Amino acid modifications
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	270	1	N-linked (GlcNAc...) Potential
	Disulfide bond	255 ↔ 296		By similarity
Natural variations
	Natural variant	160	1	L → H. Corresponds to variant rs8106673 [ dbSNP | Ensembl ].		VAR_043976
	Natural variant	161	1	T → A. Corresponds to variant rs12610545 [ dbSNP | Ensembl ].		VAR_043977

Sequences

	Sequence		Length	Mass (Da)
	A8MTB9 [UniParc]. Last modified May 1, 2013. Version 4. Checksum: B7D3DDB65B282C3B	FASTA	384	43,320
	10 20 30 40 50 60 MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD KVPEDVQEYS 70 80 90 100 110 120 WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL LIRPTALNDT GNYTVRVVAG 130 140 150 160 170 180 NETQRATGWL EVLELGSNLG ISVNASSLVE NMDSVAADCL TNVTNITWYV NDVPTSSSDR 190 200 210 220 230 240 MTISPDGKTL VILRVSRYDR TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN 250 260 270 280 290 300 GIVTAEIGSQ VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN 310 320 330 340 350 360 PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW SPDPCSDQPL 370 380 LNQDKSGSMS VHPRPEDKTR RASR

References

[1]

"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020914 Genomic DNA. No translation available.
IPI	IPI00893126.
RefSeq	NP_001073874.1. NM_001080405.1.
UniGene	Hs.653111.
3D structure databases
ProteinModelPortal	A8MTB9.
SMR	A8MTB9. Positions 102-288.
ModBase	Search...
PTM databases
PhosphoSite	A8MTB9.
Proteomic databases
PaxDb	A8MTB9.
PRIDE	A8MTB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000451626; ENSP00000402203; ENSG00000213822.
GeneID	729767.
KEGG	hsa:729767.
UCSC	uc002pwv.1. human.
Organism-specific databases
CTD	729767.
GeneCards	GC19P051979.
HGNC	HGNC:31949. CEACAM18.
neXtProt	NX_A8MTB9.
PharmGKB	PA142672132.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44627.
HOGENOM	HOG000111529.
HOVERGEN	HBG107644.
InParanoid	A8MTB9.
KO	K06499.
Gene expression databases
ArrayExpress	A8MTB9.
CleanEx	HS_CEACAM18.
Genevestigator	A8MTB9.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	131287.

Entry information

Entry name

CEA18_HUMAN

Accession

Primary (citable) accession number: A8MTB9
Secondary accession number(s): C9JN24

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	May 1, 2013
Last modified:	May 1, 2013
This is version 42 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.