Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carcinoembryonic antigen-related cell adhesion molecule 18

Gene

CEACAM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 18
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31949. CEACAM18.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213822.
PharmGKBiPA142672132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000033937831 – 384Carcinoembryonic antigen-related cell adhesion molecule 18Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 296PROSITE-ProRule annotation
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA8MTB9.
PRIDEiA8MTB9.

Expressioni

Gene expression databases

CleanExiHS_CEACAM18.

Organism-specific databases

HPAiHPA059487.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000402203.

Structurei

3D structure databases

ProteinModelPortaliA8MTB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 314Ig-like C2-typeAdd BLAST88

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410JB7I. Eukaryota.
ENOG4111BYI. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000111529.
HOVERGENiHBG107644.
InParanoidiA8MTB9.
OMAiSQVEMEC.
OrthoDBiEOG091G0AAA.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8MTB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSRPRWSL WRRVFLMASL LACGICQASG QIFITQTLGI KGYRTVVALD
60 70 80 90 100
KVPEDVQEYS WYWGANDSAG NMIISHKPPS AQQPGPMYTG RERVNREGSL
110 120 130 140 150
LIRPTALNDT GNYTVRVVAG NETQRATGWL EVLELGSNLG ISVNASSLVE
160 170 180 190 200
NMDSVAADCL TNVTNITWYV NDVPTSSSDR MTISPDGKTL VILRVSRYDR
210 220 230 240 250
TIQCMIESFP EIFQRSERIS LTVAYGPDYV LLRSNPDDFN GIVTAEIGSQ
260 270 280 290 300
VEMECICYSF LDLKYHWIHN GSLLNFSDAK MNLSSLAWEQ MGRYRCTVEN
310 320 330 340 350
PVTQLIMYMD VRIQAPHEDL TCCPQRFLHL RIHGDVPHHA DSAGWRLHLW
360 370 380
SPDPCSDQPL LNQDKSGSMS VHPRPEDKTR RASR
Length:384
Mass (Da):43,320
Last modified:May 1, 2013 - v4
Checksum:iB7D3DDB65B282C3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043976160L → H.Corresponds to variant rs8106673dbSNPEnsembl.1
Natural variantiVAR_043977161T → A.Corresponds to variant rs12610545dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020914 Genomic DNA. No translation available.
UniGeneiHs.653111.

Genome annotation databases

EnsembliENST00000396477; ENSP00000379738; ENSG00000213822.
UCSCiuc061bxs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020914 Genomic DNA. No translation available.
UniGeneiHs.653111.

3D structure databases

ProteinModelPortaliA8MTB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402203.

Proteomic databases

PaxDbiA8MTB9.
PRIDEiA8MTB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396477; ENSP00000379738; ENSG00000213822.
UCSCiuc061bxs.1. human.

Organism-specific databases

GeneCardsiCEACAM18.
HGNCiHGNC:31949. CEACAM18.
HPAiHPA059487.
neXtProtiNX_A8MTB9.
OpenTargetsiENSG00000213822.
PharmGKBiPA142672132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB7I. Eukaryota.
ENOG4111BYI. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000111529.
HOVERGENiHBG107644.
InParanoidiA8MTB9.
OMAiSQVEMEC.
OrthoDBiEOG091G0AAA.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:G66-32624-MONOMER.

Miscellaneous databases

PROiA8MTB9.

Gene expression databases

CleanExiHS_CEACAM18.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEA18_HUMAN
AccessioniPrimary (citable) accession number: A8MTB9
Secondary accession number(s): C9JN24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 1, 2013
Last modified: November 2, 2016
This is version 70 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.