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Protein

Protein FAM166B

Gene

FAM166B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM166B
Gene namesi
Name:FAM166B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000215187.9.
HGNCiHGNC:34242. FAM166B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215187.
PharmGKBiPA162387040.

Polymorphism and mutation databases

BioMutaiFAM166B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003423831 – 275Protein FAM166BAdd BLAST275

Proteomic databases

PaxDbiA8MTA8.
PRIDEiA8MTA8.
TopDownProteomicsiA8MTA8-2. [A8MTA8-2]

PTM databases

iPTMnetiA8MTA8.
PhosphoSitePlusiA8MTA8.

Expressioni

Gene expression databases

BgeeiENSG00000215187.
CleanExiHS_FAM166B.
ExpressionAtlasiA8MTA8. baseline and differential.
GenevisibleiA8MTA8. HS.

Organism-specific databases

HPAiHPA045540.

Interactioni

Protein-protein interaction databases

BioGridi610500. 1 interactor.
IntActiA8MTA8. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliA8MTA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0605 family.Curated

Phylogenomic databases

eggNOGiENOG410IPQ1. Eukaryota.
ENOG4111J2F. LUCA.
GeneTreeiENSGT00730000111299.
HOGENOMiHOG000231525.
HOVERGENiHBG070076.
InParanoidiA8MTA8.
OMAiTYPQNLG.
OrthoDBiEOG091G0B21.
PhylomeDBiA8MTA8.
TreeFamiTF325739.

Family and domain databases

InterProiView protein in InterPro
IPR018902. UPF0573/UPF0605.
PfamiView protein in Pfam
PF10629. DUF2475. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MTA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVASTFIPG LNPQNPHYIP GYTGHCPLLR FSVGQTYGQV TGQLLRGPPG
60 70 80 90 100
LAWPPVHRTL LPPIRPPRSP EVPRESLPVR RGQERLSSSM IPGYTGFVPR
110 120 130 140 150
AQFIFAKNCS QVWAEALSDF THLHEKQGSE ELPKEAKGRK DTEKDQVPEP
160 170 180 190 200
EGQLEEPTLE VVEQASPYSM DDRDPRKFFM SGFTGYVPCA RFLFGSSFPV
210 220 230 240 250
LTNQALQEFG QKHSPGSAQD PKHLPPLPRT YPQNLGLLPN YGGYVPGYKF
260 270
QFGHTFGHLT HDALGLSTFQ KQLLA
Length:275
Mass (Da):30,575
Last modified:December 4, 2007 - v1
Checksum:iFF307EA7A191945F
GO
Isoform 2 (identifier: A8MTA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-239: FTGYVPCARF...TYPQNLGLLP → TAGIWAEALTRQCPGPQTSPPTSQNIPSEPGSFT
     240-275: Missing.

Show »
Length:216
Mass (Da):23,839
Checksum:iAA30258DEC259FC5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034438183 – 239FTGYV…LGLLP → TAGIWAEALTRQCPGPQTSP PTSQNIPSEPGSFT in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034439240 – 275Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133476 Genomic DNA. No translation available.
BC129999 mRNA. Translation: AAI30000.1.
BC146928 mRNA. Translation: AAI46929.1.
BC146933 mRNA. Translation: AAI46934.1.
CCDSiCCDS47963.1. [A8MTA8-2]
CCDS56572.1. [A8MTA8-1]
RefSeqiNP_001093421.1. NM_001099951.3. [A8MTA8-2]
NP_001157782.1. NM_001164310.2. [A8MTA8-1]
NP_001274168.1. NM_001287239.1.
UniGeneiHs.98959.

Genome annotation databases

EnsembliENST00000399742; ENSP00000382646; ENSG00000215187. [A8MTA8-1]
ENST00000447837; ENSP00000412746; ENSG00000215187. [A8MTA8-2]
ENST00000639789; ENSP00000492818; ENSG00000215187. [A8MTA8-2]
GeneIDi730112.
KEGGihsa:730112.
UCSCiuc003zwy.4. human. [A8MTA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF166B_HUMAN
AccessioniPrimary (citable) accession number: A8MTA8
Secondary accession number(s): A1L3B2, B7ZBJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 4, 2007
Last modified: September 27, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries