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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 14

Gene

AGAP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative GTPase-activating protein.Curated

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of the chromosome 10.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri478 – 501C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 14Curated
Alternative name(s):
ArfGAP with GTPase domain, ankyrin repeat and PH domain 14 pseudogene
Centaurin-gamma-like family member 11 pseudogeneImported
Gene namesi
Name:AGAP14Imported
Synonyms:AGAP14P, CTGLF11PImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23660. AGAP14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489411 – 685Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 14Add BLAST685

Proteomic databases

PRIDEiA8MT82.

Expressioni

Organism-specific databases

HPAiHPA042490.

Structurei

3D structure databases

ProteinModelPortaliA8MT82.
SMRiA8MT82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 442PHPROSITE-ProRule annotationAdd BLAST162
Domaini463 – 583Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati622 – 651ANK 1Add BLAST30
Repeati655 – 684ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri478 – 501C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG054045.
InParanoidiA8MT82.
OMAiLQRNSQT.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PRINTSiPR00405. REVINTRACTNG.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MT82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHVRDR EMPEALEFNL SANPEASTIL QRNSQTDALE
110 120 130 140 150
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL
160 170 180 190 200
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LSFAVSTVHI
210 220 230 240 250
TKNRNGGGSL NNYSSSIPST PSTSQEDPQF SVPPTANTPT PVCKRSMCWS
260 270 280 290 300
NLFTSEKGSH PDKERKAPEN HADTIGSSRA IPIKQGMLLK RSGKWLKTWK
310 320 330 340 350
KKYVTLCSNG VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP GKWPSLATSA
360 370 380 390 400
SAPISSSKSN GLSKDMDTGL GDSICFSPSI SSTTSPKLNL PPSPHANKKK
410 420 430 440 450
HLKKKSTNNF MIVSATGQTW HFEATTYEER DAWVQAIQSQ IVASLQSCES
460 470 480 490 500
SKSKSQLTSQ SEAMALQSIQ NMRGNAHCVD CETQNPKWAS LNLGVLMCIE
510 520 530 540 550
CSGIHCSLGT RLSRVRSLEL DDWPVELRKV MSSIGNDLAN SIWEGSSQGQ
560 570 580 590 600
TKPSVKSTRE EKERWIRSKY EKKLFLAPLP CTELSLGQHL LRATADEDLQ
610 620 630 640 650
TAILLLAHGS REEVNETCGE GDGCTALHLA CRKGNVVLAQ LLIWYRVDVM
660 670 680
ARDAHGNTAL TYARQASSQE CINVLLQYGC PDECV
Length:685
Mass (Da):75,435
Last modified:March 15, 2017 - v3
Checksum:i99BA0498C3FCA1B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244230 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244230 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA8MT82.
SMRiA8MT82.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA8MT82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

HGNCiHGNC:23660. AGAP14.
HPAiHPA042490.
neXtProtiNX_A8MT82.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG054045.
InParanoidiA8MT82.
OMAiLQRNSQT.

Miscellaneous databases

PROiPR:A8MT82.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PRINTSiPR00405. REVINTRACTNG.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGP14_HUMAN
AccessioniPrimary (citable) accession number: A8MT82
Secondary accession number(s): A0A096LNP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.