A8MT82 (CTLFB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative centaurin-gamma-like family member 11P

Gene names

Name:

CTGLF11P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of the chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular_function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 671	671	Putative centaurin-gamma-like family member 11P		PRO_0000348941
Regions
	Domain	267 – 428	162	PH
	Domain	449 – 569	121	Arf-GAP
	Repeat	608 – 637	30	ANK 1
	Repeat	641 – 670	30	ANK 2
	Zinc finger	464 – 487	24	C4-type

Sequences

	Sequence		Length	Mass (Da)
	A8MT82 [UniParc]. Last modified September 2, 2008. Version 2. Checksum: DFC4E5F84EC3B25F	FASTA	671	74,058
	10 20 30 40 50 60 MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAKDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STERFSQQYS 130 140 150 160 170 180 SCSTIFLDDS TASQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLTH LRHSSFCSTQ 190 200 210 220 230 240 VSTVHITKNR NGGGSLNNYS SSIPSTPSTS QEDPQFSVPP TANTPTPVCK WSMCWSNLFT 250 260 270 280 290 300 SEKGSHPDKE RKAPENHADT IGSSRAIPIK QGMLLKRSGK WLKTWKKKYV TLCSNGVLTY 310 320 330 340 350 360 YSSLGDYMKN IHKKEIDLRT STIKVPGKWP SLATSACAPI SSSKSNGLSK DMDTGLGDSI 370 380 390 400 410 420 CFSPSISSTT SPKLNLPPSP HANKKKHLKK KSTNNFMIVS ATGQTWHFEA TTYEERDAWV 430 440 450 460 470 480 QAIQSQIVAS LQSCESSKSK SQLTSQSEAM ALQSIQNMRG NAHCVDCETQ NPKWASLNLG 490 500 510 520 530 540 VLMCIECSGI HCSLGTRLSR VRSLELDDWP VELRKVMSSI GNDLANSIWE GSSQGQTKPS 550 560 570 580 590 600 VKSTREEKER WIRSKYEKKL FLAPLPCTEL SLGQHLLRAT ADEDLQTAIL LLAHGSREEV 610 620 630 640 650 660 NETCGEGDGC TALHLACRKG NVVLAQLLIW YRVDVMARDA HGNTALTYAR QASSQECINV 670 LLQYGCPDEC V

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL603965 Genomic DNA. No translation available.
IPI	IPI00873461.
3D structure databases
ProteinModelPortal	A8MT82.
ModBase	Search...
Proteomic databases
PRIDE	A8MT82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC10P047708.
HGNC	HGNC:23660. CTGLF11P.
HPA	HPA042490.
neXtProt	NX_A8MT82.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG054045.
InParanoid	A8MT82.
Gene expression databases
Genevestigator	A8MT82.
Family and domain databases
Gene3D	1.25.40.20. 1 hit. 2.30.29.30. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTLFB_HUMAN

Accession

Primary (citable) accession number: A8MT82

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.