A8MT70 (ZBBX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger B-box domain-containing protein 1

Gene names

Name:

ZBBX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	800 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 B box-type zinc finger.
Sequence caution	The sequence BAB15532.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A8MT70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: A8MT70-2)

The sequence of this isoform differs from the canonical sequence as follows:
     626-626: A → AEDREWIPDHSLSEYADNAIVLGVLQGAQSPSSSRKQQKM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 800	800	Zinc finger B-box domain-containing protein 1		PRO_0000325813
Regions
	Zinc finger	129 – 175	47	B box-type; atypical
	Coiled coil	21 – 64	44	Potential
	Coiled coil	693 – 720	28	Potential
	Compositional bias	641 – 674	34	Ser-rich
	Compositional bias	780 – 783	4	Poly-Glu
Natural variations
	Alternative sequence	626	1	A → AEDREWIPDHSLSEYADNAI VLGVLQGAQSPSSSRKQQKM in isoform 2.		VSP_035573
	Natural variant	14	1	P → T. Corresponds to variant rs10936535 [ dbSNP | Ensembl ].		VAR_048400
	Natural variant	160	1	K → N. Corresponds to variant rs4619784 [ dbSNP | Ensembl ].		VAR_048401
	Natural variant	178	1	K → R. Corresponds to variant rs11923054 [ dbSNP | Ensembl ].		VAR_048402
	Natural variant	346	1	H → R. Corresponds to variant rs34465133 [ dbSNP | Ensembl ].		VAR_061040
	Natural variant	473	1	A → G. Ref.2 Corresponds to variant rs13096767 [ dbSNP | Ensembl ].		VAR_048403
	Natural variant	511	1	I → T. Corresponds to variant rs35190925 [ dbSNP | Ensembl ].		VAR_048404
	Natural variant	555	1	E → K. Corresponds to variant rs35864545 [ dbSNP | Ensembl ].		VAR_048405
	Natural variant	636	1	A → G. Ref.2 Corresponds to variant rs12638625 [ dbSNP | Ensembl ].		VAR_046955
Experimental info
	Sequence conflict	273	1	N → K in BAB15532. Ref.2
	Sequence conflict	339	1	P → S in BAB15532. Ref.2
	Sequence conflict	576	1	L → S in BAG52683. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: D008D3C3D4DE00C3	FASTA	800	91,426
	10 20 30 40 50 60 MNRKDFVVLP WGKPGNSVKL KYRNAQELRM EKVQLEFENQ EMEKKLQEFR STRNKEKEDR 70 80 90 100 110 120 ESSEYYWKSG KVGKLVNQSY MMSQNKGNVV KFSAGKVKLK LLKEQIQEPV KPTVNYKMAN 130 140 150 160 170 180 SSECEKPKIN GKVCGQCENK AALLVCLECG EDYCSGCFAK VHQKGALKLH RTTLLQAKSQ 190 200 210 220 230 240 ILFNVLDVAH QFIKDVNPDE PKEENNSTKE TSKIQHKPKS VLLQRSSSEV EITTMKRAQR 250 260 270 280 290 300 TKPRKSLLCE GSFDEEASAQ SFQEVLSQWR TGNHDDNKKQ NLHAAVKDSL EECEVQTNLK 310 320 330 340 350 360 IWREPLNIEL KEDILSYMEK LWLKKHRRTP QEQLFKMLPD TFPHPHETTG DAQCSQNEND 370 380 390 400 410 420 EDSDGEETKV QHTALLLPVE TLNIERPEPS LKIVELDDTY EEEFEEAENI VPYKVKLADA 430 440 450 460 470 480 DSQRSCAFHD CQKNSFPYEN GIHQHHVFDK GKRDFLNLCL RNSSTYYKDN SKAETSNTDF 490 500 510 520 530 540 DNIVDPDVYS SDIEKIEEST SFERNLKEKN IGLESNQKSD DSCVSLESKD TLLGRDLEKA 550 560 570 580 590 600 PIEEKLSQDI KESLELSNLY KRPSFEESKT TKSSLLLQEI ACRSKPITKQ YQGLERFFIF 610 620 630 640 650 660 DTNERLNLLP SHRLECNNSS TRITLAGQKS QRPSTANFPL SNSVKESSSC LSSSHPRSRS 670 680 690 700 710 720 AAAQSSSRAA SEISEIEYID ITDQNELSLD DTTDQHTLDN LEKELQVLRS LADTSEKLYS 730 740 750 760 770 780 LTSEEFPDFS SQSLNISQIS TDFLKTSHVR GPCGVEELSC SGRDTKIQSL LSLSESSTDE 790 800 EEEDFLNKQH VITLPWSKST
	Isoform 2 [UniParc]. Checksum: 2D736A0DA7314002	FASTA	839	95,780
	10 20 30 40 50 60 MNRKDFVVLP WGKPGNSVKL KYRNAQELRM EKVQLEFENQ EMEKKLQEFR STRNKEKEDR 70 80 90 100 110 120 ESSEYYWKSG KVGKLVNQSY MMSQNKGNVV KFSAGKVKLK LLKEQIQEPV KPTVNYKMAN 130 140 150 160 170 180 SSECEKPKIN GKVCGQCENK AALLVCLECG EDYCSGCFAK VHQKGALKLH RTTLLQAKSQ 190 200 210 220 230 240 ILFNVLDVAH QFIKDVNPDE PKEENNSTKE TSKIQHKPKS VLLQRSSSEV EITTMKRAQR 250 260 270 280 290 300 TKPRKSLLCE GSFDEEASAQ SFQEVLSQWR TGNHDDNKKQ NLHAAVKDSL EECEVQTNLK 310 320 330 340 350 360 IWREPLNIEL KEDILSYMEK LWLKKHRRTP QEQLFKMLPD TFPHPHETTG DAQCSQNEND 370 380 390 400 410 420 EDSDGEETKV QHTALLLPVE TLNIERPEPS LKIVELDDTY EEEFEEAENI VPYKVKLADA 430 440 450 460 470 480 DSQRSCAFHD CQKNSFPYEN GIHQHHVFDK GKRDFLNLCL RNSSTYYKDN SKAETSNTDF 490 500 510 520 530 540 DNIVDPDVYS SDIEKIEEST SFERNLKEKN IGLESNQKSD DSCVSLESKD TLLGRDLEKA 550 560 570 580 590 600 PIEEKLSQDI KESLELSNLY KRPSFEESKT TKSSLLLQEI ACRSKPITKQ YQGLERFFIF 610 620 630 640 650 660 DTNERLNLLP SHRLECNNSS TRITLAEDRE WIPDHSLSEY ADNAIVLGVL QGAQSPSSSR 670 680 690 700 710 720 KQQKMGQKSQ RPSTANFPLS NSVKESSSCL SSSHPRSRSA AAQSSSRAAS EISEIEYIDI 730 740 750 760 770 780 TDQNELSLDD TTDQHTLDNL EKELQVLRSL ADTSEKLYSL TSEEFPDFSS QSLNISQIST 790 800 810 820 830 DFLKTSHVRG PCGVEELSCS GRDTKIQSLL SLSESSTDEE EEDFLNKQHV ITLPWSKST

References

[1]

"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-800 (ISOFORM 2), VARIANTS GLY-473 AND GLY-636. Tissue: Lung and Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC107311 Genomic DNA. No translation available. AC117463 Genomic DNA. No translation available. AK026702 mRNA. Translation: BAB15532.1. Different initiation. AK093296 mRNA. Translation: BAG52683.1.
IPI	IPI00002975. IPI00796568.
RefSeq	NP_078963.2. NM_024687.3.
UniGene	Hs.478143.
3D structure databases
ProteinModelPortal	A8MT70.
ModBase	Search...
Proteomic databases
PRIDE	A8MT70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000392766; ENSP00000376519; ENSG00000169064. ENST00000392767; ENSP00000376520; ENSG00000169064.
GeneID	79740.
KEGG	hsa:79740.
UCSC	uc003feo.1. human.
Organism-specific databases
CTD	79740.
GeneCards	GC03M166958.
HGNC	HGNC:26245. ZBBX.
HPA	HPA036327.
neXtProt	NX_A8MT70.
PharmGKB	PA162409400.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18065.
HOVERGEN	HBG106618.
InParanoid	A8MT70.
OMA	DVAHQFI.
OrthoDB	EOG479F6T.
Gene expression databases
Bgee	A8MT70.
CleanEx	HS_ZBBX.
Genevestigator	A8MT70.
Family and domain databases
InterPro	IPR000315. Znf_B-box. [Graphical view]
Pfam	PF00643. zf-B_box. 1 hit. [Graphical view]
PROSITE	PS50119. ZF_BBOX. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZBBX_HUMAN

Accession

Primary (citable) accession number: A8MT70
Secondary accession number(s): A8MV69 , B3KSC1, B5MDJ6, Q9H5T8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.