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Protein

Zinc finger B-box domain-containing protein 1

Gene

ZBBX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 17547B box-type; atypicalAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger B-box domain-containing protein 1
Gene namesi
Name:ZBBX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26245. ZBBX.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409400.

Polymorphism and mutation databases

BioMutaiZBBX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 800800Zinc finger B-box domain-containing protein 1PRO_0000325813Add
BLAST

Proteomic databases

PaxDbiA8MT70.
PRIDEiA8MT70.

PTM databases

iPTMnetiA8MT70.
PhosphoSiteiA8MT70.

Expressioni

Gene expression databases

BgeeiA8MT70.
CleanExiHS_ZBBX.
ExpressionAtlasiA8MT70. baseline and differential.
GenevisibleiA8MT70. HS.

Organism-specific databases

HPAiHPA036327.
HPA036328.

Interactioni

Protein-protein interaction databases

BioGridi122853. 25 interactions.

Structurei

3D structure databases

ProteinModelPortaliA8MT70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 6444Sequence analysisAdd
BLAST
Coiled coili693 – 72028Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi641 – 67434Ser-richAdd
BLAST
Compositional biasi780 – 7834Poly-Glu

Sequence similaritiesi

Contains 1 B box-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 17547B box-type; atypicalAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVIG. Eukaryota.
ENOG4111KT9. LUCA.
GeneTreeiENSGT00390000018298.
HOGENOMiHOG000136319.
HOVERGENiHBG106618.
InParanoidiA8MT70.
OMAiHRRTPQE.
OrthoDBiEOG7F7W8Q.
PhylomeDBiA8MT70.
TreeFamiTF337517.

Family and domain databases

InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MT70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRKDFVVLP WGKPGNSVKL KYRNAQELRM EKVQLEFENQ EMEKKLQEFR
60 70 80 90 100
STRNKEKEDR ESSEYYWKSG KVGKLVNQSY MMSQNKGNVV KFSAGKVKLK
110 120 130 140 150
LLKEQIQEPV KPTVNYKMAN SSECEKPKIN GKVCGQCENK AALLVCLECG
160 170 180 190 200
EDYCSGCFAK VHQKGALKLH RTTLLQAKSQ ILFNVLDVAH QFIKDVNPDE
210 220 230 240 250
PKEENNSTKE TSKIQHKPKS VLLQRSSSEV EITTMKRAQR TKPRKSLLCE
260 270 280 290 300
GSFDEEASAQ SFQEVLSQWR TGNHDDNKKQ NLHAAVKDSL EECEVQTNLK
310 320 330 340 350
IWREPLNIEL KEDILSYMEK LWLKKHRRTP QEQLFKMLPD TFPHPHETTG
360 370 380 390 400
DAQCSQNEND EDSDGEETKV QHTALLLPVE TLNIERPEPS LKIVELDDTY
410 420 430 440 450
EEEFEEAENI VPYKVKLADA DSQRSCAFHD CQKNSFPYEN GIHQHHVFDK
460 470 480 490 500
GKRDFLNLCL RNSSTYYKDN SKAETSNTDF DNIVDPDVYS SDIEKIEEST
510 520 530 540 550
SFERNLKEKN IGLESNQKSD DSCVSLESKD TLLGRDLEKA PIEEKLSQDI
560 570 580 590 600
KESLELSNLY KRPSFEESKT TKSSLLLQEI ACRSKPITKQ YQGLERFFIF
610 620 630 640 650
DTNERLNLLP SHRLECNNSS TRITLAGQKS QRPSTANFPL SNSVKESSSC
660 670 680 690 700
LSSSHPRSRS AAAQSSSRAA SEISEIEYID ITDQNELSLD DTTDQHTLDN
710 720 730 740 750
LEKELQVLRS LADTSEKLYS LTSEEFPDFS SQSLNISQIS TDFLKTSHVR
760 770 780 790 800
GPCGVEELSC SGRDTKIQSL LSLSESSTDE EEEDFLNKQH VITLPWSKST
Note: No experimental confirmation available.
Length:800
Mass (Da):91,426
Last modified:October 14, 2008 - v3
Checksum:iD008D3C3D4DE00C3
GO
Isoform 3 (identifier: A8MT70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.
Show »
Length:771
Mass (Da):87,999
Checksum:iDA50F4C1E52A1733
GO
Isoform 2 (identifier: A8MT70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-626: A → AEDREWIPDHSLSEYADNAIVLGVLQGAQSPSSSRKQQKM

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):95,780
Checksum:i2D736A0DA7314002
GO

Sequence cautioni

The sequence BAB15532.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731N → K in BAB15532 (PubMed:14702039).Curated
Sequence conflicti339 – 3391P → S in BAB15532 (PubMed:14702039).Curated
Sequence conflicti576 – 5761L → S in BAG52683 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141P → T.
Corresponds to variant rs10936535 [ dbSNP | Ensembl ].
VAR_048400
Natural varianti160 – 1601K → N.
Corresponds to variant rs4619784 [ dbSNP | Ensembl ].
VAR_048401
Natural varianti178 – 1781K → R.
Corresponds to variant rs11923054 [ dbSNP | Ensembl ].
VAR_048402
Natural varianti346 – 3461H → R.
Corresponds to variant rs34465133 [ dbSNP | Ensembl ].
VAR_061040
Natural varianti473 – 4731A → G.1 Publication
Corresponds to variant rs13096767 [ dbSNP | Ensembl ].
VAR_048403
Natural varianti511 – 5111I → T.
Corresponds to variant rs35190925 [ dbSNP | Ensembl ].
VAR_048404
Natural varianti555 – 5551E → K.
Corresponds to variant rs35864545 [ dbSNP | Ensembl ].
VAR_048405
Natural varianti636 – 6361A → G.1 Publication
Corresponds to variant rs12638625 [ dbSNP | Ensembl ].
VAR_046955

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 3. CuratedVSP_054851Add
BLAST
Alternative sequencei626 – 6261A → AEDREWIPDHSLSEYADNAI VLGVLQGAQSPSSSRKQQKM in isoform 2. 1 PublicationVSP_035573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107311 Genomic DNA. No translation available.
AC117463 Genomic DNA. No translation available.
AK026702 mRNA. Translation: BAB15532.1. Different initiation.
AK093296 mRNA. Translation: BAG52683.1.
CCDSiCCDS3199.2. [A8MT70-1]
CCDS56295.1. [A8MT70-3]
CCDS56296.1. [A8MT70-2]
RefSeqiNP_078963.2. NM_024687.3. [A8MT70-1]
UniGeneiHs.478143.

Genome annotation databases

EnsembliENST00000307529; ENSP00000305065; ENSG00000169064. [A8MT70-2]
ENST00000392764; ENSP00000376517; ENSG00000169064. [A8MT70-3]
ENST00000392766; ENSP00000376519; ENSG00000169064. [A8MT70-1]
ENST00000392767; ENSP00000376520; ENSG00000169064. [A8MT70-3]
ENST00000455345; ENSP00000390232; ENSG00000169064. [A8MT70-2]
GeneIDi79740.
UCSCiuc003fep.4. human. [A8MT70-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107311 Genomic DNA. No translation available.
AC117463 Genomic DNA. No translation available.
AK026702 mRNA. Translation: BAB15532.1. Different initiation.
AK093296 mRNA. Translation: BAG52683.1.
CCDSiCCDS3199.2. [A8MT70-1]
CCDS56295.1. [A8MT70-3]
CCDS56296.1. [A8MT70-2]
RefSeqiNP_078963.2. NM_024687.3. [A8MT70-1]
UniGeneiHs.478143.

3D structure databases

ProteinModelPortaliA8MT70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122853. 25 interactions.

PTM databases

iPTMnetiA8MT70.
PhosphoSiteiA8MT70.

Polymorphism and mutation databases

BioMutaiZBBX.

Proteomic databases

PaxDbiA8MT70.
PRIDEiA8MT70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307529; ENSP00000305065; ENSG00000169064. [A8MT70-2]
ENST00000392764; ENSP00000376517; ENSG00000169064. [A8MT70-3]
ENST00000392766; ENSP00000376519; ENSG00000169064. [A8MT70-1]
ENST00000392767; ENSP00000376520; ENSG00000169064. [A8MT70-3]
ENST00000455345; ENSP00000390232; ENSG00000169064. [A8MT70-2]
GeneIDi79740.
UCSCiuc003fep.4. human. [A8MT70-1]

Organism-specific databases

CTDi79740.
GeneCardsiZBBX.
HGNCiHGNC:26245. ZBBX.
HPAiHPA036327.
HPA036328.
neXtProtiNX_A8MT70.
PharmGKBiPA162409400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVIG. Eukaryota.
ENOG4111KT9. LUCA.
GeneTreeiENSGT00390000018298.
HOGENOMiHOG000136319.
HOVERGENiHBG106618.
InParanoidiA8MT70.
OMAiHRRTPQE.
OrthoDBiEOG7F7W8Q.
PhylomeDBiA8MT70.
TreeFamiTF337517.

Miscellaneous databases

GenomeRNAii79740.
NextBioi69142.
PROiA8MT70.

Gene expression databases

BgeeiA8MT70.
CleanExiHS_ZBBX.
ExpressionAtlasiA8MT70. baseline and differential.
GenevisibleiA8MT70. HS.

Family and domain databases

InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-800 (ISOFORM 2), VARIANTS GLY-473 AND GLY-636.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiZBBX_HUMAN
AccessioniPrimary (citable) accession number: A8MT70
Secondary accession number(s): A8MV69
, B3KSC1, B5MDJ6, F2Z370, Q9H5T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 14, 2008
Last modified: March 16, 2016
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.