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Protein

Zinc finger protein 891

Gene

ZNF891

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 891
Gene namesi
Name:ZNF891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:38709. ZNF891.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491851 – 544Zinc finger protein 891Add BLAST544

Proteomic databases

MaxQBiA8MT65.
PaxDbiA8MT65.
PRIDEiA8MT65.

PTM databases

iPTMnetiA8MT65.
PhosphoSitePlusiA8MT65.

Expressioni

Gene expression databases

BgeeiENSG00000214029.
GenevisibleiA8MT65. HS.

Organism-specific databases

HPAiHPA040301.

Interactioni

Protein-protein interaction databases

BioGridi136313. 1 interactor.
STRINGi9606.ENSP00000380480.

Structurei

3D structure databases

ProteinModelPortaliA8MT65.
SMRiA8MT65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 113KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 342C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOVERGENiHBG018163.
InParanoidiA8MT65.
KOiK09228.
OMAiKHECNQC.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MT65.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MT65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV
60 70 80 90 100
EFTQEEWMML DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI
110 120 130 140 150
RNMKKRIPQA ICPDQKIQPK TKESTVQKIL WEEPSNAVKM IKLTMHNWSS
160 170 180 190 200
TLREDWECHK IRKQHKIPGG HWRQMIYAPK KTVPQELFRD YHELEENSKL
210 220 230 240 250
GSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI SEKLYESHEC
260 270 280 290 300
DTTLWHFQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
310 320 330 340 350
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC
360 370 380 390 400
KECGKVFNDS STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG
410 420 430 440 450
EKPYECNQCG KSFGTSSYLI VHKRIHTGEK LYECSECGKA FNTSSHLKVH
460 470 480 490 500
KKIHTGENVY ECSDCGKVFS GVSSLRMHIR THTGEKPYEC KECRKAFSVS
510 520 530 540
SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE RETL
Length:544
Mass (Da):63,592
Last modified:September 2, 2008 - v2
Checksum:iB8639429E306B007
GO

Sequence cautioni

The sequence BC017932 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026786 Genomic DNA. No translation available.
BC017932 mRNA. No translation available.
CCDSiCCDS59238.1.
RefSeqiNP_001264220.1. NM_001277291.1.
XP_016874155.1. XM_017018666.1.
XP_016874156.1. XM_017018667.1.
XP_016874157.1. XM_017018668.1.
UniGeneiHs.614816.

Genome annotation databases

EnsembliENST00000537226; ENSP00000437590; ENSG00000214029.
GeneIDi101060200.
KEGGihsa:101060200.
UCSCiuc031qkm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026786 Genomic DNA. No translation available.
BC017932 mRNA. No translation available.
CCDSiCCDS59238.1.
RefSeqiNP_001264220.1. NM_001277291.1.
XP_016874155.1. XM_017018666.1.
XP_016874156.1. XM_017018667.1.
XP_016874157.1. XM_017018668.1.
UniGeneiHs.614816.

3D structure databases

ProteinModelPortaliA8MT65.
SMRiA8MT65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136313. 1 interactor.
STRINGi9606.ENSP00000380480.

PTM databases

iPTMnetiA8MT65.
PhosphoSitePlusiA8MT65.

Proteomic databases

MaxQBiA8MT65.
PaxDbiA8MT65.
PRIDEiA8MT65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537226; ENSP00000437590; ENSG00000214029.
GeneIDi101060200.
KEGGihsa:101060200.
UCSCiuc031qkm.2. human.

Organism-specific databases

CTDi101060200.
GeneCardsiZNF891.
HGNCiHGNC:38709. ZNF891.
HPAiHPA040301.
neXtProtiNX_A8MT65.
OpenTargetsiENSG00000214029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOVERGENiHBG018163.
InParanoidiA8MT65.
KOiK09228.
OMAiKHECNQC.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MT65.
TreeFamiTF337055.

Miscellaneous databases

GenomeRNAii101060200.
PROiA8MT65.

Gene expression databases

BgeeiENSG00000214029.
GenevisibleiA8MT65. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN891_HUMAN
AccessioniPrimary (citable) accession number: A8MT65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.