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A8MSY0 (S72L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2

Short name=CTD phosphatase SSU72-like protein 2
EC=3.1.3.16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2
PRO_0000341199

Regions

Coiled coil160 – 18627 Potential

Sequences

Sequence LengthMass (Da)Tools
A8MSY0 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 705B07B3E111709D

FASTA19422,430
        10         20         30         40         50         60 
MLSSTLRVAV VCVSNVNRSM EAHSILRKKG LSVRSFGTES HVRLPGPRPN RPVVYDFATT 

        70         80         90        100        110        120 
YKEMYNDLLR KDRECYTRNG ILHILGRNER IKPGPERFQE CTDFFDVIFT CEESVYDTVV 

       130        140        150        160        170        180 
EDLCSREQQT FQPVHVINME IQDTLEDATL GAFLICEICQ CLQQSDDMED NLEELLLQME 

       190 
EKAGKSFLHT VCFY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC018793 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalA8MSY0.
SMRA8MSY0. Positions 6-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000391256.

PTM databases

PhosphoSiteA8MSY0.

Proteomic databases

PaxDbA8MSY0.
PRIDEA8MSY0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

neXtProtNX_A8MSY0.

Phylogenomic databases

eggNOGCOG5211.
HOGENOMHOG000183445.
HOVERGENHBG059831.
InParanoidA8MSY0.
PhylomeDBA8MSY0.

Gene expression databases

GenevestigatorA8MSY0.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry nameS72L2_HUMAN
AccessionPrimary (citable) accession number: A8MSY0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM