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Protein

Histone deacetylase

Gene

HD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107SubstrateUniRule annotation1
Active sitei149Proton acceptorUniRule annotation1
Binding sitei157Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi184Divalent metal cationUniRule annotation1
Metal bindingi186Divalent metal cationUniRule annotation1
Metal bindingi272Divalent metal cationUniRule annotation1
Binding sitei311SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:HD1Imported
Synonyms:ATHD1Imported, ATHDA19Imported, ATRPD3AImported, HDA1Imported, HDA19Imported, HISTONE DEACETYLASEImported, histone deacetylase 1Imported, HISTONE DEACETYLASE 19Imported, HISTONE DEACETYLASE19Imported, RPD3AImported
Ordered Locus Names:At4g38130Imported
ORF Names:F20D10.250Imported, F20D10_250Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G38130.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiA8MSD0.
PRIDEiA8MSD0.

PTM databases

iPTMnetiA8MSD0.

Expressioni

Gene expression databases

ExpressionAtlasiA8MSD0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA8MSD0.
SMRiA8MSD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 324Hist_deacetylInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

A8MSD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGGNSLAS GPDGVKRKVC YFYDPEVGNY YYGQGHPMKP HRIRMTHALL
60 70 80 90 100
AHYGLLQHMQ VLKPFPARDR DLCRFHADDY VSFLRSITPE TQQDQIRQLK
110 120 130 140 150
RFNVGEDCPV FDGLYSFCQT YAGGSVGGSV KLNHGLCDIA INWAGGLHHA
160 170 180 190 200
KKCEASGFCY VNDIVLAILE LLKQHERVLY VDIDIHHGDG VEEAFYATDR
210 220 230 240 250
VMTVSFHKFG DYFPGTGHIQ DIGYGSGKYY SLNVPLDDGI DDESYHLLFK
260 270 280 290 300
PIMGKVMEIF RPGAVVLQCG ADSLSGDRLG CFNLSIKGHA ECVKFMRSFN
310 320 330 340 350
VPLLLLGGGG YTIRNVARCW CYETGVALGV EVEDKMPEHE YYEYFGPDYT
360 370 380 390 400
LHVAPSNMEN KNSRQMLEEI RNDLLHNLSK LQHAPSVPFQ ERPPDTETPE
410 420 430 440 450
VDEDQEDGDK RWDPDSDMDV DDDRKPIPSR VKREAVEPDT KDKDGLKGIM
460
ERGKGCEVEV DESGSTKVK
Length:469
Mass (Da):52,780
Last modified:December 4, 2007 - v1
Checksum:i63AA007E54AD2328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA. Translation: AEE86882.1.
RefSeqiNP_001078511.1. NM_001085042.1.
UniGeneiAt.25069.

Genome annotation databases

EnsemblPlantsiAT4G38130.2; AT4G38130.2; AT4G38130.
GeneIDi829969.
GrameneiAT4G38130.2; AT4G38130.2; AT4G38130.

Similar proteinsi

Entry informationi

Entry nameiA8MSD0_ARATH
AccessioniPrimary (citable) accession number: A8MSD0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported