ID A8MRW9_ARATH Unreviewed; 393 AA. AC A8MRW9; DT 04-DEC-2007, integrated into UniProtKB/TrEMBL. DT 04-DEC-2007, sequence version 1. DT 24-JAN-2024, entry version 104. DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007}; GN Name=HXK2 {ECO:0000313|EMBL:AEC06935.1, ECO:0000313|TAIR:AT2G19860}; GN Synonyms=ATHXK2 {ECO:0000313|EMBL:AEC06935.1}, HEXOKINASE 2 GN {ECO:0000313|EMBL:AEC06935.1}, hexokinase 2 GN {ECO:0000313|EMBL:AEC06935.1}; GN OrderedLocusNames=At2g19860 {ECO:0000313|Araport:AT2G19860, GN ECO:0000313|EMBL:AEC06935.1}; GN ORFNames=F6F22.11 {ECO:0000313|EMBL:AEC06935.1}, F6F22_11 GN {ECO:0000313|EMBL:AEC06935.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEC06935.1, ECO:0000313|Proteomes:UP000006548}; RN [1] {ECO:0000313|EMBL:AEC06935.1, ECO:0000313|Proteomes:UP000006548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S., Shea T.P., Benito M.I., Town C.D., RA Fujii C.Y., Mason T., Bowman C.L., Barnstead M., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J., Ronning C.M., Koo H.L., Moffat K.S., RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."; RL Nature 402:761-768(1999). RN [2] {ECO:0000313|Proteomes:UP000006548} RP GENOME REANNOTATION. RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548}; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|ARBA:ARBA00004888}. CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism. CC {ECO:0000256|ARBA:ARBA00005028}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002685; AEC06935.1; -; Genomic_DNA. DR RefSeq; NP_001077921.1; NM_001084452.2. DR AlphaFoldDB; A8MRW9; -. DR SMR; A8MRW9; -. DR ProteomicsDB; 194139; -. DR EnsemblPlants; AT2G19860.2; AT2G19860.2; AT2G19860. DR GeneID; 816505; -. DR Gramene; AT2G19860.2; AT2G19860.2; AT2G19860. DR Araport; AT2G19860; -. DR TAIR; AT2G19860; HXK2. DR HOGENOM; CLU_014393_5_1_1; -. DR UniPathway; UPA00109; UER00180. DR UniPathway; UPA00242; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; A8MRW9; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProt. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004340; F:glucokinase activity; IEA:UniProt. DR GO; GO:0005536; F:glucose binding; IEA:InterPro. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway. DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 1. DR Gene3D; 3.40.367.20; -; 1. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; HEXOKINASE; 1. DR PANTHER; PTHR19443:SF79; HEXOKINASE-2; 1. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PRINTS; PR00475; HEXOKINASE. DR SUPFAM; SSF53067; Actin-like ATPase domain; 2. DR PROSITE; PS00378; HEXOKINASE_1; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007}; KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU362007}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A8MRW9, KW ECO:0007829|ProteomicsDB:A8MRW9}; KW Reference proteome {ECO:0000313|Proteomes:UP000006548}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}. FT DOMAIN 2..131 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 138..378 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" SQ SEQUENCE 393 AA; 42926 MW; 2DFB7DB4A521D2FF CRC64; MRVLLGGKHD RVVKREFKEE SIPPHLMTGK SHELFDFIVD VLAKFVATEG EDFHLPPGRQ RELGFTFSFP VKQLSLSSGT LINWTKGFSI DDTVDKDVVG ELVKAMERVG LDMLVAALVN DTIGTLAGGR YTNPDVVVAV ILGTGTNAAY VERAHAIPKW HGLLPKSGEM VINMEWGNFR SSHLPLTEYD HSLDVDSLNP GEQILEKIIS GMYLGEILRR VLLKMAEEAA FFGDIVPPKL KIPFIIRTPN MSAMHSDTSP DLKVVGSKLK DILEVQTSSL KMRKVVISLC NIIASRGARL SAAGIYGILK KIGRDATKDG EAQKSVIAMD GGLFEHYTQF SESMKSSLKE LLGDEVSESV EVILSNDGSG VGAALLAASH SQYLELEDDS ETS //