ID   A8MRB1_HUMAN            Unreviewed;        94 AA.
AC   A8MRB1;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=S100 calcium binding protein B {ECO:0000313|EMBL:ALQ33778.1, ECO:0000313|Ensembl:ENSP00000356038.4};
GN   Name=S100B {ECO:0000313|EMBL:ALQ33778.1,
GN   ECO:0000313|Ensembl:ENSP00000356038.4};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356038.4, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356038.4, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|EMBL:ALQ33778.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26871637; DOI=10.1016/j.cell.2016.01.029;
RA   Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T.,
RA   Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K.,
RA   Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q.,
RA   Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D.,
RA   Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J.,
RA   Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P.,
RA   Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.;
RT   "Widespread Expansion of Protein Interaction Capabilities by Alternative
RT   Splicing.";
RL   Cell 164:805-817(2016).
RN   [3] {ECO:0000313|Ensembl:ENSP00000356038.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- INTERACTION:
CC       A8MRB1; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-16432654, EBI-11522760;
CC       A8MRB1; Q96B96: LDAF1; NbExp=3; IntAct=EBI-16432654, EBI-7055862;
CC       A8MRB1; Q969L2: MAL2; NbExp=3; IntAct=EBI-16432654, EBI-944295;
CC       A8MRB1; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-16432654, EBI-712367;
CC       A8MRB1; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-16432654, EBI-11528917;
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DR   EMBL; AP000339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KU178320; ALQ33778.1; -; mRNA.
DR   IntAct; A8MRB1; 5.
DR   ProteomicsDB; 1957; -.
DR   Antibodypedia; 3474; 2022 antibodies from 45 providers.
DR   Ensembl; ENST00000367071.4; ENSP00000356038.4; ENSG00000160307.10.
DR   UCSC; uc002zjv.2; human.
DR   HGNC; HGNC:10500; S100B.
DR   VEuPathDB; HostDB:ENSG00000160307; -.
DR   GeneTree; ENSGT00940000161997; -.
DR   HOGENOM; CLU_184875_0_0_1; -.
DR   ChiTaRS; S100B; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000160307; Expressed in C1 segment of cervical spinal cord and 159 other cell types or tissues.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   PANTHER; PTHR11639:SF134; PROTEIN S100-A1-RELATED; 1.
DR   PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:A8MRB1,
KW   ECO:0007829|MaxQB:A8MRB1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          4..46
FT                   /note="S100/CaBP-9k-type calcium binding subdomain"
FT                   /evidence="ECO:0000259|SMART:SM01394"
FT   REGION          71..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   94 AA;  10343 MW;  ADDC888C374E35C6 CRC64;
     MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLERWSL PMLPRLVSNF
     LCSSYPPALA SQSAGITGNQ RAGGCGQSHG NTGQ
//