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Protein

Golgin subfamily A member 8B

Gene

GOLGA8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in maintaining Golgi structure.By similarity

Enzyme and pathway databases

BioCyciZFISH:G66-32540-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 8B
Alternative name(s):
Golgin-67
Gene namesi
Name:GOLGA8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:31973. GOLGA8B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi440270.
OpenTargetsiENSG00000215252.
PharmGKBiPA142671717.

Polymorphism and mutation databases

BioMutaiGOLGA8B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160911 – 603Golgin subfamily A member 8BAdd BLAST603

Proteomic databases

MaxQBiA8MQT2.
PaxDbiA8MQT2.
PRIDEiA8MQT2.

PTM databases

iPTMnetiA8MQT2.
PhosphoSitePlusiA8MQT2.

Expressioni

Tissue specificityi

Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000215252.
ExpressionAtlasiA8MQT2. baseline and differential.
GenevisibleiA8MQT2. HS.

Organism-specific databases

HPAiHPA051808.

Structurei

3D structure databases

ProteinModelPortaliA8MQT2.
SMRiA8MQT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni491 – 603Golgi-targeting domainAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili82 – 173Sequence analysisAdd BLAST92
Coiled coili212 – 440Sequence analysisAdd BLAST229

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOVERGENiHBG051752.
InParanoidiA8MQT2.
PhylomeDBiA8MQT2.
TreeFamiTF316990.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MQT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEETGQSKL AAAKKKFKEY WQRNRPGVPA AAKRNTKANG SSPETAASGG
60 70 80 90 100
CHSSEASSSA SSSLHARQSP CQEQAAVLNS RSIKISRLND TIKSLKQQKK
110 120 130 140 150
QVEHQLEEEK KANNEKQKAE RELEGQIQRL NTEKKKLNTD LYHMKHSLRY
160 170 180 190 200
FEEESKDLAG RLQRSSQRIG ELEWSLCAVA ATQKKKPDGF SSRSKALLKR
210 220 230 240 250
QLEQSIREQI LLKGHVTQLK ESLKEVQLER DQYAEQIKGE RAQWQQRMRK
260 270 280 290 300
MSQEVCTLKE EKKHDTHRVE ELERSLSRLK NQMAEPLPPD APAVSSEVEL
310 320 330 340 350
QDLRKELERV AGELQAQVEN NQCISLLNRG QKERLREQEE RLQEQQERLR
360 370 380 390 400
EREKRLQQLA EPQSDLEELK HENKSALQLE QQVKELQEKL GQVMETLTSA
410 420 430 440 450
EKEPEAAVPA SGTGGESSGL MDLLEEKADL REHVEKLELG FIQYRRERCH
460 470 480 490 500
QKVHRLLTEP GDSAKDASPG GGHHQAGPGQ GGEEGEAAGA AGDGVAACGS
510 520 530 540 550
YSEGHGKFLA AARNPAAEPS PGAPAPQELG AADKHGDLCE ASLTNSVEPA
560 570 580 590 600
QGEAREGSSQ DNPTAQPVLQ LLGEMQDHQE HPGLGSNCCV PCFCWAWLPR

RRR
Length:603
Mass (Da):67,278
Last modified:January 15, 2008 - v2
Checksum:iE314724D662AC0E4
GO
Isoform 2 (identifier: A8MQT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:460
Mass (Da):51,408
Checksum:i528FAE1BD8341C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181A → T in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti352R → Q in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti352R → Q in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti352R → Q in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti360A → S in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti370Missing in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti394M → T in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti394M → T in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti394M → T in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti428A → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti428A → V in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti452K → N in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti468S → A in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti480Q → R in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti480Q → R in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti480Q → R in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti488A → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti488A → V in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti488A → V in AAI04801 (PubMed:15489334).Curated1
Sequence conflicti493D → N in AAF34136 (PubMed:10660574).Curated1
Sequence conflicti569L → V in AAF40308 (PubMed:10677249).Curated1
Sequence conflicti569L → V in AAF34136 (PubMed:10660574).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0304961 – 143Missing in isoform 2. 2 PublicationsAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164622 mRNA. Translation: AAF40308.1.
AF163441 mRNA. Translation: AAF34136.1.
AC027139 Genomic DNA. No translation available.
BC104800 mRNA. Translation: AAI04801.1.
CCDSiCCDS45211.1. [A8MQT2-1]
RefSeqiNP_001018861.3. NM_001023567.4. [A8MQT2-1]
XP_011519898.1. XM_011521596.1. [A8MQT2-1]
XP_011519899.1. XM_011521597.1. [A8MQT2-1]
XP_016877699.1. XM_017022210.1. [A8MQT2-1]
XP_016877700.1. XM_017022211.1. [A8MQT2-1]
XP_016877701.1. XM_017022212.1. [A8MQT2-1]
XP_016877702.1. XM_017022213.1. [A8MQT2-1]
XP_016877704.1. XM_017022215.1. [A8MQT2-2]
XP_016877705.1. XM_017022216.1. [A8MQT2-2]
XP_016877706.1. XM_017022217.1. [A8MQT2-2]
XP_016877707.1. XM_017022218.1. [A8MQT2-2]
UniGeneiHs.182982.
Hs.720151.

Genome annotation databases

EnsembliENST00000342314; ENSP00000343064; ENSG00000215252. [A8MQT2-1]
GeneIDi440270.
KEGGihsa:440270.
UCSCiuc001ziq.4. human. [A8MQT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164622 mRNA. Translation: AAF40308.1.
AF163441 mRNA. Translation: AAF34136.1.
AC027139 Genomic DNA. No translation available.
BC104800 mRNA. Translation: AAI04801.1.
CCDSiCCDS45211.1. [A8MQT2-1]
RefSeqiNP_001018861.3. NM_001023567.4. [A8MQT2-1]
XP_011519898.1. XM_011521596.1. [A8MQT2-1]
XP_011519899.1. XM_011521597.1. [A8MQT2-1]
XP_016877699.1. XM_017022210.1. [A8MQT2-1]
XP_016877700.1. XM_017022211.1. [A8MQT2-1]
XP_016877701.1. XM_017022212.1. [A8MQT2-1]
XP_016877702.1. XM_017022213.1. [A8MQT2-1]
XP_016877704.1. XM_017022215.1. [A8MQT2-2]
XP_016877705.1. XM_017022216.1. [A8MQT2-2]
XP_016877706.1. XM_017022217.1. [A8MQT2-2]
XP_016877707.1. XM_017022218.1. [A8MQT2-2]
UniGeneiHs.182982.
Hs.720151.

3D structure databases

ProteinModelPortaliA8MQT2.
SMRiA8MQT2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA8MQT2.
PhosphoSitePlusiA8MQT2.

Polymorphism and mutation databases

BioMutaiGOLGA8B.

Proteomic databases

MaxQBiA8MQT2.
PaxDbiA8MQT2.
PRIDEiA8MQT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342314; ENSP00000343064; ENSG00000215252. [A8MQT2-1]
GeneIDi440270.
KEGGihsa:440270.
UCSCiuc001ziq.4. human. [A8MQT2-1]

Organism-specific databases

CTDi440270.
DisGeNETi440270.
GeneCardsiGOLGA8B.
H-InvDBHIX0026849.
HIX0026857.
HIX0172620.
HIX0172622.
HIX0172638.
HIX0172640.
HIX0172767.
HIX0193611.
HIX0193615.
HIX0193625.
HGNCiHGNC:31973. GOLGA8B.
HPAiHPA051808.
MIMi609619. gene.
neXtProtiNX_A8MQT2.
OpenTargetsiENSG00000215252.
PharmGKBiPA142671717.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725. Eukaryota.
ENOG410ZIE4. LUCA.
GeneTreeiENSGT00530000062932.
HOVERGENiHBG051752.
InParanoidiA8MQT2.
PhylomeDBiA8MQT2.
TreeFamiTF316990.

Enzyme and pathway databases

BioCyciZFISH:G66-32540-MONOMER.

Miscellaneous databases

ChiTaRSiGOLGA8B. human.
GenomeRNAii440270.
PROiA8MQT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215252.
ExpressionAtlasiA8MQT2. baseline and differential.
GenevisibleiA8MQT2. HS.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PfamiPF15070. GOLGA2L5. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8B_HUMAN
AccessioniPrimary (citable) accession number: A8MQT2
Secondary accession number(s): A6NLZ2
, O94937, Q2M3S9, Q9NZG8, Q9NZW0, Q9NZW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Caution

A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.