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Protein

TNF receptor-associated factor homolog 1b

Gene

TRAF1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions redundantly with TRAF1A in the regulation of plant immune response. Contributes to the turnover of the nucleotide-binding domain and leucine-rich repeat-containing (NB-LRR) immune receptors SNC1 and RPS2. May associate with an E3 ubiquitin-protein ligase complex, which modulates ubiquitination and subsequent degradation of NB-LRR immune sensors to maintain their homeostasis (PubMed:26867179). Functions redundantly with TRAF1A in the regulation of autophagosome formation. Required for SINAT1- and SINAT2-mediated ubiquitination and destabilization of ATG6. Functions as molecular adapter that helps to regulate autophagy by modulating ATG6 stability (PubMed:28351989).2 Publications

GO - Biological processi

  • autophagosome organization Source: TAIR
  • innate immune response Source: TAIR

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor homolog 1bCurated
Alternative name(s):
Protein MUTANT SNC1-ENHANCING 131 Publication
Gene namesi
Name:TRAF1B1 Publication
Synonyms:MUSE131 Publication
Ordered Locus Names:At1g04300Imported
ORF Names:F19P19.26Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G04300
TAIRilocus:2018279 AT1G04300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but the double mutant plants traf1a and traf1b, or muse13 and muse14 are extremely dwarf when grown at room temperature.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004423542 – 1082TNF receptor-associated factor homolog 1bAdd BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA8MQL1

Expressioni

Gene expression databases

ExpressionAtlasiA8MQL1 baseline and differential

Interactioni

Subunit structurei

Forms homooligomers. Interacts with SNC1, RPS2 and CPR1/CPR30 (PubMed:26867179). Interacts with ATG6 (PubMed:28351989).2 Publications

Protein-protein interaction databases

STRINGi3702.AT1G04300.3

Structurei

3D structure databases

ProteinModelPortaliA8MQL1
SMRiA8MQL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 198MATHPROSITE-ProRule annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili446 – 507Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi792 – 910Ser-richPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE0P Eukaryota
ENOG410ZKXJ LUCA
HOGENOMiHOG000238326
InParanoidiA8MQL1
OMAiHYMARGP
OrthoDBiEOG09360CT3
PhylomeDBiA8MQL1

Family and domain databases

CDDicd00121 MATH, 1 hit
Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR008974 TRAF-like
PfamiView protein in Pfam
PF00917 MATH, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MQL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAVDEDSG VGRSLEESSN GQHSQAGEAL SEWRSSGQVE NGTPSTSPSY
60 70 80 90 100
WDIDDDDDYG LKPSELYGQY TWKIPKFSEI TKREHRSNVF EAGGYKWYIL
110 120 130 140 150
IYPQGCDVCN HLSLFLCVAN YDKLLPGSFA ILEAGWSQFA QFTISVLSQD
160 170 180 190 200
LKKSKFSDTL HRFWKKEHDW GWKKFMELPK LKDGFIDESG CLTIEAKVQV
210 220 230 240 250
IRERVDRPFR CLDCGYRREL VRVYFQNVEQ ICRRFVEEKR SKLGRLIEDK
260 270 280 290 300
ARWTSFGVFW LGMDQNSRRR MCREKVDVIL KGVVKHFFVE KEVSSTLVMD
310 320 330 340 350
SLYSGLKALE GQTKNMKARS RLLDAKQLPA PIVSVDKDMF VLVDDVLLLL
360 370 380 390 400
ERAALEPLPP KDEKGRQNRT KDGNDGEEVN KEADERDERR LTELGRRTVE
410 420 430 440 450
IFILSHIFST KIEVAHQEAI ALKRQEELIR EEEEAWLAET EQRAKRGAAE
460 470 480 490 500
REKKSKKKQA KQKRNKNKGK DKRKEEKVSF ATHAKDLEEN QNQNQNDEEE
510 520 530 540 550
KDSVTEKAQS SAEKPDTLGD VSDISDSVDG SADILQPDLE DRDSSSVLWD
560 570 580 590 600
TDALEIHPPS SEGSSRGRGI SISTPNGITE GKSHSTMDDS SSTCSNDSIR
610 620 630 640 650
SGVTNGSYQG NSLNFRNQKS PNKGKNQQVK AMTDAHSLAS ETDDQPSTLG
660 670 680 690 700
TDPKGQNYSS EASNVGESDW VVVSHIQEPE GSRNRIPVGR ERKTVQSIVN
710 720 730 740 750
SVDMDRPKEK STAVLSSPRN VAKNPSPLTQ TKPEKKSIST ADGIPNRKVL
760 770 780 790 800
ATGPPSSSQV VLPSDIQSQT VGLRADMQKL SAPKQPPATT ISRPSSAPII
810 820 830 840 850
PAMRPSPITV SSSVQTTTSL PRSVSSAGRL GPDPSLHNQQ TYTPQSYKNA
860 870 880 890 900
IVGNSLGSSS SSFNHHPSSH GVVPTTLPSS SYSQAPTSSY QSSFPYSQDG
910 920 930 940 950
LLWTGRSPSS VNMGMYNNTY SPAVTSNRSL NHMDVQIAQQ QAQSMMTDEF
960 970 980 990 1000
PHLDIINDLL EDEQCSNMVY NGSIFNPQPQ VFNGQYSSYH GELLSGGRTR
1010 1020 1030 1040 1050
SFGEEGLHYM ARGPYGTDGM MPRQWQMTNM DLSLPAMRSN GMEDGTSSAA
1060 1070 1080
NYHHSYFGLD ASNPSFTSGI NGYTEFRPSN GH
Length:1,082
Mass (Da):120,444
Last modified:December 4, 2007 - v1
Checksum:i95B9398A3BC750A3
GO
Isoform 2 (identifier: A8MQL1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: MAEAVDEDSG...CVANYDKLLP → MFVIISPCFS...LFSLWIPSHV

Show »
Length:997
Mass (Da):111,018
Checksum:i5D449EFBF920CB3C
GO

Sequence cautioni

The sequence AAB70446 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324D → G in BAF01316 (Ref. 3) Curated1
Sequence conflicti837H → R in BAF01316 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0592311 – 126MAEAV…DKLLP → MFVIISPCFSVLQIMINFFQ VSIIVHLSAWSLFSLWIPSH V in isoform 2. Add BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000104 Genomic DNA Translation: AAB70446.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27681.1
CP002684 Genomic DNA Translation: AEE27682.1
AK229458 mRNA Translation: BAF01316.1
PIRiE86174
RefSeqiNP_001077454.1, NM_001083985.1 [A8MQL1-2]
NP_001077455.1, NM_001083986.1 [A8MQL1-1]
UniGeneiAt.24558

Genome annotation databases

EnsemblPlantsiAT1G04300.2; AT1G04300.2; AT1G04300 [A8MQL1-2]
AT1G04300.3; AT1G04300.3; AT1G04300 [A8MQL1-1]
GeneIDi839551
GrameneiAT1G04300.2; AT1G04300.2; AT1G04300 [A8MQL1-2]
AT1G04300.3; AT1G04300.3; AT1G04300 [A8MQL1-1]
KEGGiath:AT1G04300

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRF1B_ARATH
AccessioniPrimary (citable) accession number: A8MQL1
Secondary accession number(s): F4I479
, P93826, P93827, Q0WNI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: December 4, 2007
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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