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A8MQ27

- NEU1B_HUMAN

UniProt

A8MQ27 - NEU1B_HUMAN

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Protein

E3 ubiquitin-protein ligase NEURL1B

Gene
NEURL1B, NEURL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri503 – 54341RING-typeAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase NEURL1B (EC:6.3.2.-)
Alternative name(s):
Neuralized-2
Short name:
NEUR2
Neuralized-like protein 1B
Neuralized-like protein 3
Gene namesi
Name:NEURL1B
Synonyms:NEURL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:35422. NEURL1B.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555E3 ubiquitin-protein ligase NEURL1BPRO_0000349382Add
BLAST

Proteomic databases

PaxDbiA8MQ27.
PRIDEiA8MQ27.

PTM databases

PhosphoSiteiA8MQ27.

Expressioni

Tissue specificityi

Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.1 Publication

Gene expression databases

BgeeiA8MQ27.
GenevestigatoriA8MQ27.

Organism-specific databases

HPAiHPA037612.

Interactioni

Subunit structurei

Interacts with JAG1, DLL1 and DLL4.1 Publication

Protein-protein interaction databases

BioGridi119989. 2 interactions.
STRINGi9606.ENSP00000358815.

Structurei

3D structure databases

ProteinModelPortaliA8MQ27.
SMRiA8MQ27. Positions 40-194, 280-427, 503-553.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 194157NHR 1Add
BLAST
Domaini279 – 433155NHR 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi252 – 2587Poly-Ala
Compositional biasi437 – 49155Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG145384.
HOGENOMiHOG000233742.
InParanoidiA8MQ27.
KOiK01931.
OMAiAIPCGPR.
OrthoDBiEOG7C2R0S.
PhylomeDBiA8MQ27.
TreeFamiTF314368.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTiSM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A8MQ27-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV    50
RLDGHSRRAT RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG 100
FTAHDPSLMS AQDIPKYACP DLVTRPGYWA KALPENLALR DTVLAYWADR 150
HGRVFYSVND GEPVLFHCGV AVGGPLWALI DVYGITDEVQ LLESAFADTL 200
TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH LALGRAPGPP 250
PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC 300
APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL 350
RPNELPADPD ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING 400
RPRGRLLCVD TTQALWAFFA VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG 450
SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS PLSPPVSPVF SPPEPAGIKN 500
GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP ICRRPIKDVI 550
KIYRP 555
Length:555
Mass (Da):59,270
Last modified:December 4, 2007 - v1
Checksum:i228B459336279423
GO
Isoform 2 (identifier: A8MQ27-2) [UniParc]FASTAAdd to Basket

Also known as: delta-NHR1

The sequence of this isoform differs from the canonical sequence as follows:
     11-192: Missing.

Show »
Length:373
Mass (Da):39,058
Checksum:i2EA7D029C5E62A91
GO
Isoform 3 (identifier: A8MQ27-3) [UniParc]FASTAAdd to Basket

Also known as: delta-NHR2

The sequence of this isoform differs from the canonical sequence as follows:
     191-430: Missing.

Show »
Length:315
Mass (Da):34,230
Checksum:iC7AC47D5CBD9B54B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 192182Missing in isoform 2. VSP_044404Add
BLAST
Alternative sequencei191 – 430240Missing in isoform 3. VSP_044405Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ414757 mRNA. Translation: ACV53563.1.
GQ414758 mRNA. Translation: ACV53564.1.
GQ414759 mRNA. Translation: ACV53565.1.
AC027309 Genomic DNA. No translation available.
CCDSiCCDS47342.1. [A8MQ27-1]
RefSeqiNP_001136123.1. NM_001142651.1. [A8MQ27-1]
UniGeneiHs.91521.

Genome annotation databases

EnsembliENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1]
ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3]
ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2]
GeneIDi54492.
KEGGihsa:54492.
UCSCiuc003mbt.3. human. [A8MQ27-1]
uc021yhs.1. human. [A8MQ27-2]
uc021yht.1. human. [A8MQ27-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GQ414757 mRNA. Translation: ACV53563.1 .
GQ414758 mRNA. Translation: ACV53564.1 .
GQ414759 mRNA. Translation: ACV53565.1 .
AC027309 Genomic DNA. No translation available.
CCDSi CCDS47342.1. [A8MQ27-1 ]
RefSeqi NP_001136123.1. NM_001142651.1. [A8MQ27-1 ]
UniGenei Hs.91521.

3D structure databases

ProteinModelPortali A8MQ27.
SMRi A8MQ27. Positions 40-194, 280-427, 503-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119989. 2 interactions.
STRINGi 9606.ENSP00000358815.

PTM databases

PhosphoSitei A8MQ27.

Proteomic databases

PaxDbi A8MQ27.
PRIDEi A8MQ27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369800 ; ENSP00000358815 ; ENSG00000214357 . [A8MQ27-1 ]
ENST00000520919 ; ENSP00000429797 ; ENSG00000214357 . [A8MQ27-3 ]
ENST00000522853 ; ENSP00000430001 ; ENSG00000214357 . [A8MQ27-2 ]
GeneIDi 54492.
KEGGi hsa:54492.
UCSCi uc003mbt.3. human. [A8MQ27-1 ]
uc021yhs.1. human. [A8MQ27-2 ]
uc021yht.1. human. [A8MQ27-3 ]

Organism-specific databases

CTDi 54492.
GeneCardsi GC05P172068.
HGNCi HGNC:35422. NEURL1B.
HPAi HPA037612.
neXtProti NX_A8MQ27.
PharmGKBi PA164723819.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145384.
HOGENOMi HOG000233742.
InParanoidi A8MQ27.
KOi K01931.
OMAi AIPCGPR.
OrthoDBi EOG7C2R0S.
PhylomeDBi A8MQ27.
TreeFami TF314368.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi NEURL1B. human.
GenomeRNAii 54492.
NextBioi 35484036.
PROi A8MQ27.

Gene expression databases

Bgeei A8MQ27.
Genevestigatori A8MQ27.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF07177. Neuralized. 2 hits.
[Graphical view ]
SMARTi SM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands."
    Rullinkov G., Tamme R., Sarapuu A., Lauren J., Sepp M., Palm K., Timmusk T.
    Biochem. Biophys. Res. Commun. 389:420-425(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH DLL1 AND DLL4, TISSUE SPECIFICITY.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNEU1B_HUMAN
AccessioniPrimary (citable) accession number: A8MQ27
Secondary accession number(s): C9DQJ5, C9DQJ6, C9DQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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