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Protein

E3 ubiquitin-protein ligase NEURL1B

Gene

NEURL1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 543RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2644606. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
R-HSA-2691232. Constitutive Signaling by NOTCH1 HD Domain Mutants.
R-HSA-2894862. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase NEURL1B (EC:6.3.2.-)
Alternative name(s):
Neuralized-2
Short name:
NEUR2
Neuralized-like protein 1B
Neuralized-like protein 3
Gene namesi
Name:NEURL1B
Synonyms:NEURL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:35422. NEURL1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214357.
PharmGKBiPA164723819.

Polymorphism and mutation databases

BioMutaiNEURL1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493821 – 555E3 ubiquitin-protein ligase NEURL1BAdd BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA8MQ27.
PRIDEiA8MQ27.

PTM databases

iPTMnetiA8MQ27.
PhosphoSitePlusiA8MQ27.

Expressioni

Tissue specificityi

Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.1 Publication

Gene expression databases

BgeeiENSG00000214357.
GenevisibleiA8MQ27. HS.

Organism-specific databases

HPAiHPA037612.
HPA057518.

Interactioni

Subunit structurei

Interacts with JAG1, DLL1 and DLL4.1 Publication

Protein-protein interaction databases

BioGridi119989. 2 interactors.
STRINGi9606.ENSP00000358815.

Structurei

3D structure databases

ProteinModelPortaliA8MQ27.
SMRiA8MQ27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 194NHR 1PROSITE-ProRule annotationAdd BLAST157
Domaini279 – 433NHR 2PROSITE-ProRule annotationAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 258Poly-Ala7
Compositional biasi437 – 491Ser-richAdd BLAST55

Sequence similaritiesi

Contains 2 NHR (neuralized homology repeat) domains.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 543RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4172. Eukaryota.
KOG4625. Eukaryota.
ENOG410ZMNG. LUCA.
GeneTreeiENSGT00530000063117.
HOGENOMiHOG000233742.
InParanoidiA8MQ27.
KOiK01931.
OMAiHHGWSGA.
OrthoDBiEOG091G04VO.
PhylomeDBiA8MQ27.
TreeFamiTF314368.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006573. NHR_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTiSM00588. NEUZ. 2 hits.
[Graphical view]
PROSITEiPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A8MQ27-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV
60 70 80 90 100
RLDGHSRRAT RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG
110 120 130 140 150
FTAHDPSLMS AQDIPKYACP DLVTRPGYWA KALPENLALR DTVLAYWADR
160 170 180 190 200
HGRVFYSVND GEPVLFHCGV AVGGPLWALI DVYGITDEVQ LLESAFADTL
210 220 230 240 250
TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH LALGRAPGPP
260 270 280 290 300
PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC
310 320 330 340 350
APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL
360 370 380 390 400
RPNELPADPD ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING
410 420 430 440 450
RPRGRLLCVD TTQALWAFFA VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG
460 470 480 490 500
SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS PLSPPVSPVF SPPEPAGIKN
510 520 530 540 550
GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP ICRRPIKDVI

KIYRP
Length:555
Mass (Da):59,270
Last modified:December 4, 2007 - v1
Checksum:i228B459336279423
GO
Isoform 2 (identifier: A8MQ27-2) [UniParc]FASTAAdd to basket
Also known as: delta-NHR1

The sequence of this isoform differs from the canonical sequence as follows:
     11-192: Missing.

Show »
Length:373
Mass (Da):39,058
Checksum:i2EA7D029C5E62A91
GO
Isoform 3 (identifier: A8MQ27-3) [UniParc]FASTAAdd to basket
Also known as: delta-NHR2

The sequence of this isoform differs from the canonical sequence as follows:
     191-430: Missing.

Show »
Length:315
Mass (Da):34,230
Checksum:iC7AC47D5CBD9B54B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04440411 – 192Missing in isoform 2. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_044405191 – 430Missing in isoform 3. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ414757 mRNA. Translation: ACV53563.1.
GQ414758 mRNA. Translation: ACV53564.1.
GQ414759 mRNA. Translation: ACV53565.1.
AC027309 Genomic DNA. No translation available.
CCDSiCCDS47342.1. [A8MQ27-1]
CCDS78085.1. [A8MQ27-3]
CCDS83042.1. [A8MQ27-2]
RefSeqiNP_001136123.1. NM_001142651.2. [A8MQ27-1]
NP_001295106.1. NM_001308177.1. [A8MQ27-2]
NP_001295107.1. NM_001308178.1. [A8MQ27-3]
UniGeneiHs.91521.

Genome annotation databases

EnsembliENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1]
ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3]
ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2]
GeneIDi54492.
KEGGihsa:54492.
UCSCiuc003mbt.4. human. [A8MQ27-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ414757 mRNA. Translation: ACV53563.1.
GQ414758 mRNA. Translation: ACV53564.1.
GQ414759 mRNA. Translation: ACV53565.1.
AC027309 Genomic DNA. No translation available.
CCDSiCCDS47342.1. [A8MQ27-1]
CCDS78085.1. [A8MQ27-3]
CCDS83042.1. [A8MQ27-2]
RefSeqiNP_001136123.1. NM_001142651.2. [A8MQ27-1]
NP_001295106.1. NM_001308177.1. [A8MQ27-2]
NP_001295107.1. NM_001308178.1. [A8MQ27-3]
UniGeneiHs.91521.

3D structure databases

ProteinModelPortaliA8MQ27.
SMRiA8MQ27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119989. 2 interactors.
STRINGi9606.ENSP00000358815.

PTM databases

iPTMnetiA8MQ27.
PhosphoSitePlusiA8MQ27.

Polymorphism and mutation databases

BioMutaiNEURL1B.

Proteomic databases

PaxDbiA8MQ27.
PRIDEiA8MQ27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1]
ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3]
ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2]
GeneIDi54492.
KEGGihsa:54492.
UCSCiuc003mbt.4. human. [A8MQ27-1]

Organism-specific databases

CTDi54492.
GeneCardsiNEURL1B.
HGNCiHGNC:35422. NEURL1B.
HPAiHPA037612.
HPA057518.
MIMi615893. gene.
neXtProtiNX_A8MQ27.
OpenTargetsiENSG00000214357.
PharmGKBiPA164723819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4172. Eukaryota.
KOG4625. Eukaryota.
ENOG410ZMNG. LUCA.
GeneTreeiENSGT00530000063117.
HOGENOMiHOG000233742.
InParanoidiA8MQ27.
KOiK01931.
OMAiHHGWSGA.
OrthoDBiEOG091G04VO.
PhylomeDBiA8MQ27.
TreeFamiTF314368.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2644606. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
R-HSA-2691232. Constitutive Signaling by NOTCH1 HD Domain Mutants.
R-HSA-2894862. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Miscellaneous databases

ChiTaRSiNEURL1B. human.
GenomeRNAii54492.
PROiA8MQ27.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214357.
GenevisibleiA8MQ27. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006573. NHR_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTiSM00588. NEUZ. 2 hits.
[Graphical view]
PROSITEiPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU1B_HUMAN
AccessioniPrimary (citable) accession number: A8MQ27
Secondary accession number(s): C9DQJ5, C9DQJ6, C9DQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.