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A8MQ27 (NEU1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase NEURL1B

EC=6.3.2.-
Alternative name(s):
Neuralized-2
Short name=NEUR2
Neuralized-like protein 1B
Neuralized-like protein 3
Gene names
Name:NEURL1B
Synonyms:NEURL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. Ref.1

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with JAG1, DLL1 and DLL4. Ref.1

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe. Ref.1

Sequence similarities

Contains 2 NHR (neuralized homology repeat) domains.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processNotch signaling pathway
Ubl conjugation pathway
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A8MQ27-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A8MQ27-2)

Also known as: delta-NHR1;

The sequence of this isoform differs from the canonical sequence as follows:
     11-192: Missing.
Isoform 3 (identifier: A8MQ27-3)

Also known as: delta-NHR2;

The sequence of this isoform differs from the canonical sequence as follows:
     191-430: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555E3 ubiquitin-protein ligase NEURL1B
PRO_0000349382

Regions

Domain38 – 194157NHR 1
Domain279 – 433155NHR 2
Zinc finger503 – 54341RING-type
Compositional bias252 – 2587Poly-Ala
Compositional bias437 – 49155Ser-rich

Natural variations

Alternative sequence11 – 192182Missing in isoform 2.
VSP_044404
Alternative sequence191 – 430240Missing in isoform 3.
VSP_044405

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 4, 2007. Version 1.
Checksum: 228B459336279423

FASTA55559,270
        10         20         30         40         50         60 
MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV RLDGHSRRAT 

        70         80         90        100        110        120 
RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP 

       130        140        150        160        170        180 
DLVTRPGYWA KALPENLALR DTVLAYWADR HGRVFYSVND GEPVLFHCGV AVGGPLWALI 

       190        200        210        220        230        240 
DVYGITDEVQ LLESAFADTL TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH 

       250        260        270        280        290        300 
LALGRAPGPP PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC 

       310        320        330        340        350        360 
APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL RPNELPADPD 

       370        380        390        400        410        420 
ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING RPRGRLLCVD TTQALWAFFA 

       430        440        450        460        470        480 
VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS 

       490        500        510        520        530        540 
PLSPPVSPVF SPPEPAGIKN GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP 

       550 
ICRRPIKDVI KIYRP 

« Hide

Isoform 2 (delta-NHR1) [UniParc].

Checksum: 2EA7D029C5E62A91
Show »

FASTA37339,058
Isoform 3 (delta-NHR2) [UniParc].

Checksum: C7AC47D5CBD9B54B
Show »

FASTA31534,230

References

« Hide 'large scale' references
[1]"Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands."
Rullinkov G., Tamme R., Sarapuu A., Lauren J., Sepp M., Palm K., Timmusk T.
Biochem. Biophys. Res. Commun. 389:420-425(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH DLL1 AND DLL4, TISSUE SPECIFICITY.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GQ414757 mRNA. Translation: ACV53563.1.
GQ414758 mRNA. Translation: ACV53564.1.
GQ414759 mRNA. Translation: ACV53565.1.
AC027309 Genomic DNA. No translation available.
CCDSCCDS47342.1. [A8MQ27-1]
RefSeqNP_001136123.1. NM_001142651.1. [A8MQ27-1]
UniGeneHs.91521.

3D structure databases

ProteinModelPortalA8MQ27.
SMRA8MQ27. Positions 40-194, 280-427, 503-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119989. 2 interactions.
STRING9606.ENSP00000358815.

PTM databases

PhosphoSiteA8MQ27.

Proteomic databases

PaxDbA8MQ27.
PRIDEA8MQ27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1]
ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3]
ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2]
GeneID54492.
KEGGhsa:54492.
UCSCuc003mbt.3. human. [A8MQ27-1]
uc021yhs.1. human. [A8MQ27-2]
uc021yht.1. human. [A8MQ27-3]

Organism-specific databases

CTD54492.
GeneCardsGC05P172068.
HGNCHGNC:35422. NEURL1B.
HPAHPA037612.
neXtProtNX_A8MQ27.
PharmGKBPA164723819.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145384.
HOGENOMHOG000233742.
InParanoidA8MQ27.
KOK01931.
OMAAIPCGPR.
OrthoDBEOG7C2R0S.
PhylomeDBA8MQ27.
TreeFamTF314368.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
UniPathwayUPA00143.

Gene expression databases

BgeeA8MQ27.
GenevestigatorA8MQ27.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTSM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEURL1B. human.
GenomeRNAi54492.
NextBio35484036.
PROA8MQ27.

Entry information

Entry nameNEU1B_HUMAN
AccessionPrimary (citable) accession number: A8MQ27
Secondary accession number(s): C9DQJ5, C9DQJ6, C9DQJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM