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A8MQ27

- NEU1B_HUMAN

UniProt

A8MQ27 - NEU1B_HUMAN

Protein

E3 ubiquitin-protein ligase NEURL1B

Gene

NEURL1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri503 – 54341RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. Notch signaling pathway Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Notch signaling pathway, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1B (EC:6.3.2.-)
    Alternative name(s):
    Neuralized-2
    Short name:
    NEUR2
    Neuralized-like protein 1B
    Neuralized-like protein 3
    Gene namesi
    Name:NEURL1B
    Synonyms:NEURL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:35422. NEURL1B.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164723819.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555E3 ubiquitin-protein ligase NEURL1BPRO_0000349382Add
    BLAST

    Proteomic databases

    PaxDbiA8MQ27.
    PRIDEiA8MQ27.

    PTM databases

    PhosphoSiteiA8MQ27.

    Expressioni

    Tissue specificityi

    Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.1 Publication

    Gene expression databases

    BgeeiA8MQ27.
    GenevestigatoriA8MQ27.

    Organism-specific databases

    HPAiHPA037612.

    Interactioni

    Subunit structurei

    Interacts with JAG1, DLL1 and DLL4.1 Publication

    Protein-protein interaction databases

    BioGridi119989. 2 interactions.
    STRINGi9606.ENSP00000358815.

    Structurei

    3D structure databases

    ProteinModelPortaliA8MQ27.
    SMRiA8MQ27. Positions 40-194, 280-427, 503-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 194157NHR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 433155NHR 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi252 – 2587Poly-Ala
    Compositional biasi437 – 49155Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 NHR (neuralized homology repeat) domains.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri503 – 54341RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG145384.
    HOGENOMiHOG000233742.
    InParanoidiA8MQ27.
    KOiK01931.
    OMAiAIPCGPR.
    OrthoDBiEOG7C2R0S.
    PhylomeDBiA8MQ27.
    TreeFamiTF314368.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR006573. Neu_Z.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF07177. Neuralized. 2 hits.
    [Graphical view]
    SMARTiSM00588. NEUZ. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS51065. NHR. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A8MQ27-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV    50
    RLDGHSRRAT RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG 100
    FTAHDPSLMS AQDIPKYACP DLVTRPGYWA KALPENLALR DTVLAYWADR 150
    HGRVFYSVND GEPVLFHCGV AVGGPLWALI DVYGITDEVQ LLESAFADTL 200
    TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH LALGRAPGPP 250
    PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC 300
    APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL 350
    RPNELPADPD ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING 400
    RPRGRLLCVD TTQALWAFFA VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG 450
    SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS PLSPPVSPVF SPPEPAGIKN 500
    GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP ICRRPIKDVI 550
    KIYRP 555
    Length:555
    Mass (Da):59,270
    Last modified:December 4, 2007 - v1
    Checksum:i228B459336279423
    GO
    Isoform 2 (identifier: A8MQ27-2) [UniParc]FASTAAdd to Basket

    Also known as: delta-NHR1

    The sequence of this isoform differs from the canonical sequence as follows:
         11-192: Missing.

    Show »
    Length:373
    Mass (Da):39,058
    Checksum:i2EA7D029C5E62A91
    GO
    Isoform 3 (identifier: A8MQ27-3) [UniParc]FASTAAdd to Basket

    Also known as: delta-NHR2

    The sequence of this isoform differs from the canonical sequence as follows:
         191-430: Missing.

    Show »
    Length:315
    Mass (Da):34,230
    Checksum:iC7AC47D5CBD9B54B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 192182Missing in isoform 2. 1 PublicationVSP_044404Add
    BLAST
    Alternative sequencei191 – 430240Missing in isoform 3. 1 PublicationVSP_044405Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ414757 mRNA. Translation: ACV53563.1.
    GQ414758 mRNA. Translation: ACV53564.1.
    GQ414759 mRNA. Translation: ACV53565.1.
    AC027309 Genomic DNA. No translation available.
    CCDSiCCDS47342.1. [A8MQ27-1]
    RefSeqiNP_001136123.1. NM_001142651.1. [A8MQ27-1]
    UniGeneiHs.91521.

    Genome annotation databases

    EnsembliENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1]
    ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3]
    ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2]
    GeneIDi54492.
    KEGGihsa:54492.
    UCSCiuc003mbt.3. human. [A8MQ27-1]
    uc021yhs.1. human. [A8MQ27-2]
    uc021yht.1. human. [A8MQ27-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ414757 mRNA. Translation: ACV53563.1 .
    GQ414758 mRNA. Translation: ACV53564.1 .
    GQ414759 mRNA. Translation: ACV53565.1 .
    AC027309 Genomic DNA. No translation available.
    CCDSi CCDS47342.1. [A8MQ27-1 ]
    RefSeqi NP_001136123.1. NM_001142651.1. [A8MQ27-1 ]
    UniGenei Hs.91521.

    3D structure databases

    ProteinModelPortali A8MQ27.
    SMRi A8MQ27. Positions 40-194, 280-427, 503-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119989. 2 interactions.
    STRINGi 9606.ENSP00000358815.

    PTM databases

    PhosphoSitei A8MQ27.

    Proteomic databases

    PaxDbi A8MQ27.
    PRIDEi A8MQ27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369800 ; ENSP00000358815 ; ENSG00000214357 . [A8MQ27-1 ]
    ENST00000520919 ; ENSP00000429797 ; ENSG00000214357 . [A8MQ27-3 ]
    ENST00000522853 ; ENSP00000430001 ; ENSG00000214357 . [A8MQ27-2 ]
    GeneIDi 54492.
    KEGGi hsa:54492.
    UCSCi uc003mbt.3. human. [A8MQ27-1 ]
    uc021yhs.1. human. [A8MQ27-2 ]
    uc021yht.1. human. [A8MQ27-3 ]

    Organism-specific databases

    CTDi 54492.
    GeneCardsi GC05P172068.
    HGNCi HGNC:35422. NEURL1B.
    HPAi HPA037612.
    neXtProti NX_A8MQ27.
    PharmGKBi PA164723819.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145384.
    HOGENOMi HOG000233742.
    InParanoidi A8MQ27.
    KOi K01931.
    OMAi AIPCGPR.
    OrthoDBi EOG7C2R0S.
    PhylomeDBi A8MQ27.
    TreeFami TF314368.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi NEURL1B. human.
    GenomeRNAii 54492.
    NextBioi 35484036.
    PROi A8MQ27.

    Gene expression databases

    Bgeei A8MQ27.
    Genevestigatori A8MQ27.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR006573. Neu_Z.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF07177. Neuralized. 2 hits.
    [Graphical view ]
    SMARTi SM00588. NEUZ. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS51065. NHR. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands."
      Rullinkov G., Tamme R., Sarapuu A., Lauren J., Sepp M., Palm K., Timmusk T.
      Biochem. Biophys. Res. Commun. 389:420-425(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH DLL1 AND DLL4, TISSUE SPECIFICITY.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNEU1B_HUMAN
    AccessioniPrimary (citable) accession number: A8MQ27
    Secondary accession number(s): C9DQJ5, C9DQJ6, C9DQJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3