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Protein

Zinc finger protein 850

Gene

ZNF850

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri841 – 863C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri869 – 891C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri925 – 947C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri953 – 975C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri981 – 1003C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1009 – 1031C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1059C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1087C2H2-type 32PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 850
Gene namesi
Name:ZNF850
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27994. ZNF850.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000267041.

Polymorphism and mutation databases

BioMutaiZNF850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322691 – 1090Zinc finger protein 850Add BLAST1090

Proteomic databases

PaxDbiA8MQ14.
PRIDEiA8MQ14.

PTM databases

iPTMnetiA8MQ14.
PhosphoSitePlusiA8MQ14.

Expressioni

Gene expression databases

BgeeiENSG00000267041.
ExpressionAtlasiA8MQ14. baseline and differential.
GenevisibleiA8MQ14. HS.

Organism-specific databases

HPAiHPA029299.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000464976.

Structurei

3D structure databases

ProteinModelPortaliA8MQ14.
SMRiA8MQ14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 32 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 835C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri841 – 863C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri869 – 891C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri897 – 919C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri925 – 947C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri953 – 975C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri981 – 1003C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1009 – 1031C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1037 – 1059C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1065 – 1087C2H2-type 32PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOVERGENiHBG018163.
InParanoidiA8MQ14.
KOiK09228.
OMAiPCACKEY.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MQ14.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 34 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 30 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 29 hits.
PS50157. ZINC_FINGER_C2H2_2. 32 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MQ14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMEGLVMFQ DLSIDFSQEE WECLDAAQKD LYRDVMMENY SSLVSLGLSI
60 70 80 90 100
PKPDVISLLE QGKEPWMVSR DVLGGWCRDS EFRCKTKDSC LPKEIYEVTS
110 120 130 140 150
SQWVRMEKCH SLVGSSVRDD WECKGQFQHQ DINQERYLEK AIMTYETTPT
160 170 180 190 200
FCLQTSLTLH HRIHPGEKLY KSTECMAFKY GSELTQQQET HTGEKLYKCK
210 220 230 240 250
ECGKAFHHFS YLVKHQRIHT GEKPCACKEY GKAFISGSHL IQHQKMYTDE
260 270 280 290 300
RPHECQESVK AFRPSAHLIQ HWRIHTGDKP YECKECGKSF TSGSTLNQHQ
310 320 330 340 350
QIHTGEKPYH CKQCGKSFTV GSTLIRHQQI HTGEKPYDCK ECGKSFASGS
360 370 380 390 400
ALIRHQRIHT GEKPYDCKEC GKSFTFHSAL IRHQRIHTGE KPYDCKECGK
410 420 430 440 450
SFTFRSGLIG HQAIHTGEKP YDCKECGKSF TAGSTLIQHQ RIHTGEKPYD
460 470 480 490 500
CKECGKSFAS GSALLQHQRI HTGEKPYCCK ECGKSFTFRS TRNRHQRIHT
510 520 530 540 550
GEKPYNCKEC GKSFASGSAL LQHQRIHTGE KPYHCKECGK SFTFRSGLIG
560 570 580 590 600
HQAVHTGEKP YDCKECGKSF TSRSALIQHQ RIHTGEKPYH CKECGKSFTV
610 620 630 640 650
GSTLLQHQQI HTGEKPYDCK ECGKAFRLRL RLTQHQQIHT GEKPYQCQEC
660 670 680 690 700
GKAFVSVSGL TQHHRIHTGE KPYECPDCGK AFRQRTYLNQ HRRIHTGEKP
710 720 730 740 750
YECKECGKSF TFCSGLIQHQ QNHTDEKPYD GKECGKSFTS HSTLIQHQQI
760 770 780 790 800
HTGEKPYDCK ECGKSFTSHS TLIQHQQIHT GEKLYDCKEC GKSFTSHSTL
810 820 830 840 850
IQHQPLHTGE KPYHCKECGK SFTLRSALIQ HRPVHTGEKR YSCKECGKSF
860 870 880 890 900
TSRSTLIEHQ RIHTGEKPYH CKECGKSFAF RSAIIQHRRI HTGEKPYDCK
910 920 930 940 950
ECGKAFRRRS KLTQHQRIHT GEKPYRCHEC GKAFVRFSGL TKHHSIHTGE
960 970 980 990 1000
KPYECKTCGK SFRQRTHLTL HQRIHTGDRP YECKECGKSF TCGSELIRHQ
1010 1020 1030 1040 1050
RTHTGEKPYD CKECGKAFRC PSQLSQHKRI HTGEKTYQCP ECGKAFFYAS
1060 1070 1080 1090
GLSRHQSVHT GEKPYECKTC GKAFKQLTQL TRHQRIHDLT
Length:1,090
Mass (Da):125,431
Last modified:March 8, 2011 - v2
Checksum:i6A02205E3BFB8F30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020928 Genomic DNA. No translation available.
CCDSiCCDS59379.1.
RefSeqiNP_001180481.1. NM_001193552.1.
UniGeneiHs.406307.

Genome annotation databases

EnsembliENST00000591344; ENSP00000464976; ENSG00000267041.
GeneIDi342892.
KEGGihsa:342892.
UCSCiuc010efc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020928 Genomic DNA. No translation available.
CCDSiCCDS59379.1.
RefSeqiNP_001180481.1. NM_001193552.1.
UniGeneiHs.406307.

3D structure databases

ProteinModelPortaliA8MQ14.
SMRiA8MQ14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000464976.

PTM databases

iPTMnetiA8MQ14.
PhosphoSitePlusiA8MQ14.

Polymorphism and mutation databases

BioMutaiZNF850.

Proteomic databases

PaxDbiA8MQ14.
PRIDEiA8MQ14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591344; ENSP00000464976; ENSG00000267041.
GeneIDi342892.
KEGGihsa:342892.
UCSCiuc010efc.4. human.

Organism-specific databases

CTDi342892.
GeneCardsiZNF850.
HGNCiHGNC:27994. ZNF850.
HPAiHPA029299.
neXtProtiNX_A8MQ14.
OpenTargetsiENSG00000267041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOVERGENiHBG018163.
InParanoidiA8MQ14.
KOiK09228.
OMAiPCACKEY.
OrthoDBiEOG091G02KC.
PhylomeDBiA8MQ14.

Miscellaneous databases

GenomeRNAii342892.
PROiA8MQ14.

Gene expression databases

BgeeiENSG00000267041.
ExpressionAtlasiA8MQ14. baseline and differential.
GenevisibleiA8MQ14. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 34 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 30 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 29 hits.
PS50157. ZINC_FINGER_C2H2_2. 32 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN850_HUMAN
AccessioniPrimary (citable) accession number: A8MQ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.