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Protein
Submitted name:

Rap guanine nucleotide exchange factor 5

Gene

RAPGEF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factor 5Imported
Gene namesi
Name:RAPGEF5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16862. RAPGEF5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 730713Sequence analysisPRO_5002724124Add
BLAST

Proteomic databases

MaxQBiA8MQ07.
PaxDbiA8MQ07.
PRIDEiA8MQ07.

PTM databases

iPTMnetiA8MQ07.

Expressioni

Gene expression databases

BgeeiA8MQ07.
ExpressionAtlasiA8MQ07. baseline and differential.
GenevisibleiA8MQ07. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343656.

Structurei

3D structure databases

ProteinModelPortaliA8MQ07.
SMRiA8MQ07. Positions 2-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 351134N-terminal Ras-GEFInterPro annotationAdd
BLAST
Domaini495 – 729235Ras-GEFInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
KOiK08019.
OMAiCHVYVTM.
PhylomeDBiA8MQ07.
TreeFamiTF313184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIGVWQLLL DMGIMLSVDQ HLYFQDTYVF YQFSSDECSY LYCEFEREEE
60 70 80 90 100
WQNGVKLLLQ LVPLIPARGG ICELSHQKIE DSEESSDEIL VRLTSAVQRE
110 120 130 140 150
LAAVIALKAR KSAIEQDEEN NDKHVAVTEA ESVPDSQAGV MCKLQERDEI
160 170 180 190 200
GRIELVQKLA KENYQFLQTD KKEQEKSEHQ DDEVTTVQVK EQDQSVLVLK
210 220 230 240 250
KVQCCGPAPT AGSAESHWRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET
260 270 280 290 300
LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL
310 320 330 340 350
VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL
360 370 380 390 400
GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT
410 420 430 440 450
EHSYVSVKAK VSSIAQEILK VVAEKIQYAE EDLALVAITF SGEKHELQPN
460 470 480 490 500
DLVISKSLEA SGRIYVYRKD LADTLNPFAE NEESQQRSMR ILGMNTWDLA
510 520 530 540 550
LELMNFDWSL FNSIHEQELI YFTFSRQGSG EHTANLSLLL QRCNEVQLWV
560 570 580 590 600
ATEILLCSQL GKRVQLVKKF IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR
610 620 630 640 650
LSQTWEKIPG KFKKLFSELE SLTDPSLNHK AYRDAFKKMK PPKIPFMPLL
660 670 680 690 700
LKDVTFIHEG NKTFLDNLVN FEKLHMIADT VRTLRHCRTN QFGDLSPKEH
710 720 730
QELKSYVNHL YVIDSQQALF ELSHRIEPRV
Length:730
Mass (Da):84,730
Last modified:June 28, 2011 - v3
Checksum:i62F175B2DCD9A8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005079 Genomic DNA. No translation available.
KF458405 Genomic DNA. No translation available.
KF458410 Genomic DNA. No translation available.
KF510287 Genomic DNA. No translation available.
RefSeqiNP_036426.3. NM_012294.3.
XP_005249973.1. XM_005249916.1.
UniGeneiHs.174768.
Hs.713217.

Genome annotation databases

EnsembliENST00000344041; ENSP00000343656; ENSG00000136237.
GeneIDi9771.
KEGGihsa:9771.
UCSCiuc003svg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005079 Genomic DNA. No translation available.
KF458405 Genomic DNA. No translation available.
KF458410 Genomic DNA. No translation available.
KF510287 Genomic DNA. No translation available.
RefSeqiNP_036426.3. NM_012294.3.
XP_005249973.1. XM_005249916.1.
UniGeneiHs.174768.
Hs.713217.

3D structure databases

ProteinModelPortaliA8MQ07.
SMRiA8MQ07. Positions 2-729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343656.

PTM databases

iPTMnetiA8MQ07.

Proteomic databases

MaxQBiA8MQ07.
PaxDbiA8MQ07.
PRIDEiA8MQ07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344041; ENSP00000343656; ENSG00000136237.
GeneIDi9771.
KEGGihsa:9771.
UCSCiuc003svg.4. human.

Organism-specific databases

CTDi9771.
HGNCiHGNC:16862. RAPGEF5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00810000125357.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
KOiK08019.
OMAiCHVYVTM.
PhylomeDBiA8MQ07.
TreeFamiTF313184.

Miscellaneous databases

ChiTaRSiRAPGEF5. human.
GenomeRNAii9771.
NextBioi36780.

Gene expression databases

BgeeiA8MQ07.
ExpressionAtlasiA8MQ07. baseline and differential.
GenevisibleiA8MQ07. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA8MQ07_HUMAN
AccessioniPrimary (citable) accession number: A8MQ07
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: June 28, 2011
Last modified: May 11, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.