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Protein
Submitted name:

Rap guanine nucleotide exchange factor 5

Gene

RAPGEF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rap guanine nucleotide exchange factor 5Imported
Gene namesi
Name:RAPGEF5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136237.18
HGNCiHGNC:16862 RAPGEF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136237

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500272412418 – 730Sequence analysisAdd BLAST713

Proteomic databases

EPDiA8MQ07
MaxQBiA8MQ07
PeptideAtlasiA8MQ07
PRIDEiA8MQ07

PTM databases

iPTMnetiA8MQ07

Expressioni

Gene expression databases

BgeeiENSG00000136237
ExpressionAtlasiA8MQ07 baseline and differential
GenevisibleiA8MQ07 HS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA8MQ07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 351N-terminal Ras-GEFInterPro annotationAdd BLAST134
Domaini495 – 729Ras-GEFInterPro annotationAdd BLAST235

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2378 Eukaryota
ENOG410XPX9 LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000230545
HOVERGENiHBG056985
KOiK08019
OMAiDMGIMSS
OrthoDBiEOG091G0HKG
PhylomeDBiA8MQ07
TreeFamiTF313184

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48366 SSF48366, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

A8MQ07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIGVWQLLL DMGIMLSVDQ HLYFQDTYVF YQFSSDECSY LYCEFEREEE
60 70 80 90 100
WQNGVKLLLQ LVPLIPARGG ICELSHQKIE DSEESSDEIL VRLTSAVQRE
110 120 130 140 150
LAAVIALKAR KSAIEQDEEN NDKHVAVTEA ESVPDSQAGV MCKLQERDEI
160 170 180 190 200
GRIELVQKLA KENYQFLQTD KKEQEKSEHQ DDEVTTVQVK EQDQSVLVLK
210 220 230 240 250
KVQCCGPAPT AGSAESHWRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET
260 270 280 290 300
LLDDFLLTYT VFMTTDDLCQ ALLRHYSAKK YQGKEENSDV PRRKRKVLHL
310 320 330 340 350
VSQWIALYKD WLPEDEHSKM FLKTIYRNVL DDVYEYPILE KELKEFQKIL
360 370 380 390 400
GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT
410 420 430 440 450
EHSYVSVKAK VSSIAQEILK VVAEKIQYAE EDLALVAITF SGEKHELQPN
460 470 480 490 500
DLVISKSLEA SGRIYVYRKD LADTLNPFAE NEESQQRSMR ILGMNTWDLA
510 520 530 540 550
LELMNFDWSL FNSIHEQELI YFTFSRQGSG EHTANLSLLL QRCNEVQLWV
560 570 580 590 600
ATEILLCSQL GKRVQLVKKF IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR
610 620 630 640 650
LSQTWEKIPG KFKKLFSELE SLTDPSLNHK AYRDAFKKMK PPKIPFMPLL
660 670 680 690 700
LKDVTFIHEG NKTFLDNLVN FEKLHMIADT VRTLRHCRTN QFGDLSPKEH
710 720 730
QELKSYVNHL YVIDSQQALF ELSHRIEPRV
Length:730
Mass (Da):84,730
Last modified:June 28, 2011 - v3
Checksum:i62F175B2DCD9A8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005079 Genomic DNA No translation available.
KF458405 Genomic DNA No translation available.
KF458410 Genomic DNA No translation available.
KF510287 Genomic DNA No translation available.
RefSeqiNP_036426.3, NM_012294.3
XP_005249973.1, XM_005249916.1
UniGeneiHs.174768
Hs.713217

Genome annotation databases

EnsembliENST00000344041; ENSP00000343656; ENSG00000136237
GeneIDi9771
KEGGihsa:9771
UCSCiuc003svg.4 human

Similar proteinsi

Entry informationi

Entry nameiA8MQ07_HUMAN
AccessioniPrimary (citable) accession number: A8MQ07
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 96 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health