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Protein
Submitted name:

Afadin

Gene

MLLT4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
AfadinImported
Gene namesi
Name:MLLT4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7137. MLLT4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiA8MQ02.
PaxDbiA8MQ02.
PRIDEiA8MQ02.

Expressioni

Gene expression databases

BgeeiA8MQ02.
ExpressionAtlasiA8MQ02. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375956.

Structurei

3D structure databases

ProteinModelPortaliA8MQ02.
SMRiA8MQ02. Positions 208-307, 333-462, 960-1055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292Ras-associatingInterPro annotationAdd
BLAST
Domaini205 – 307103Ras-associatingInterPro annotationAdd
BLAST
Domaini627 – 867241DiluteInterPro annotationAdd
BLAST
Domaini966 – 105287PDZ (DHR)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 14237Sequence analysisAdd
BLAST
Coiled coili1371 – 140232Sequence analysisAdd
BLAST
Coiled coili1553 – 162068Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1892. Eukaryota.
ENOG410XR0S. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000008041.
HOVERGENiHBG050463.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000253. FHA_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR008984. SMAD_FHA_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00498. FHA. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 2 hits.
[Graphical view]
SMARTiSM01132. DIL. 1 hit.
SM00240. FHA. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 2 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8MQ02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS
60 70 80 90 100
LYEVHVSGEE RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ
110 120 130 140 150
SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS DKDDRPFQGE
160 170 180 190 200
DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD
210 220 230 240 250
GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN
260 270 280 290 300
PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF
310 320 330 340 350
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS
360 370 380 390 400
PGRRNHFAYY NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF
410 420 430 440 450
GPGIQPHHCD LTNMDGVVTV TPRSMDAETY VEGQRISETT MLQSGMKVQF
460 470 480 490 500
GASHVFKFVD PSQDHALAKR SVDGGLMVKG PRHKPGIVQE TTFDLGGDIH
510 520 530 540 550
SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ PDYRRQESRT
560 570 580 590 600
QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA
610 620 630 640 650
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW
660 670 680 690 700
MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY
710 720 730 740 750
MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF
760 770 780 790 800
HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE KQGLELAADC
810 820 830 840 850
HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL LQNYHCAPDE
860 870 880 890 900
PFIPTDLIEN VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS
910 920 930 940 950
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL
960 970 980 990 1000
RENTELAQPL RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV
1010 1020 1030 1040 1050
KGGAADVDGR LAAGDQLLSV DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK
1060 1070 1080 1090 1100
QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK PRPKSEGFEL YNNSTQNGSP
1110 1120 1130 1140 1150
ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP SPGGKSAYAS
1160 1170 1180 1190 1200
GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR
1210 1220 1230 1240 1250
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR
1260 1270 1280 1290 1300
IEAAMDRKSD SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG
1310 1320 1330 1340 1350
RWKTPAAIPA TPVAVSQPIR TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP
1360 1370 1380 1390 1400
PSANQIGLPS AQVAAAERRK REEHQRWYEK EKARLEEERE RKRREQERKL
1410 1420 1430 1440 1450
GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL QPQQQPRTIE
1460 1470 1480 1490 1500
RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ
1510 1520 1530 1540 1550
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM
1560 1570 1580 1590 1600
LIMQRLEAER RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK
1610 1620 1630 1640 1650
RDAEEKRRQE EGYYSRLEAE RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE
1660 1670 1680 1690 1700
PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD SLFTAKFVAY NEEEEEEDCS
1710 1720 1730 1740 1750
LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS GAPENLTFKE
1760 1770 1780
RQRLFSQGQD VSNKVKASRK LTELENELNT K
Length:1,781
Mass (Da):201,806
Last modified:October 29, 2014 - v2
Checksum:iF68F525A0822AD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009178 Genomic DNA. No translation available.
AL049698 Genomic DNA. No translation available.
AL731868 Genomic DNA. No translation available.
KF458344 Genomic DNA. No translation available.
RefSeqiNP_001278893.1. NM_001291964.1.
UniGeneiHs.614974.
Hs.728849.
Hs.741785.

Genome annotation databases

EnsembliENST00000366806; ENSP00000355771; ENSG00000130396.
GeneIDi4301.
UCSCiuc021zik.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009178 Genomic DNA. No translation available.
AL049698 Genomic DNA. No translation available.
AL731868 Genomic DNA. No translation available.
KF458344 Genomic DNA. No translation available.
RefSeqiNP_001278893.1. NM_001291964.1.
UniGeneiHs.614974.
Hs.728849.
Hs.741785.

3D structure databases

ProteinModelPortaliA8MQ02.
SMRiA8MQ02. Positions 208-307, 333-462, 960-1055.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375956.

Proteomic databases

EPDiA8MQ02.
PaxDbiA8MQ02.
PRIDEiA8MQ02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366806; ENSP00000355771; ENSG00000130396.
GeneIDi4301.
UCSCiuc021zik.2. human.

Organism-specific databases

CTDi4301.
HGNCiHGNC:7137. MLLT4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1892. Eukaryota.
ENOG410XR0S. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000008041.
HOVERGENiHBG050463.

Miscellaneous databases

ChiTaRSiMLLT4. human.
GenomeRNAii4301.
NextBioi35464802.

Gene expression databases

BgeeiA8MQ02.
ExpressionAtlasiA8MQ02. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000253. FHA_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR008984. SMAD_FHA_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00498. FHA. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 2 hits.
[Graphical view]
SMARTiSM01132. DIL. 1 hit.
SM00240. FHA. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 2 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
    Tang L.Y., Deng N., Wang L.S., Dai J., Wang Z.L., Jiang X.S., Li S.J., Li L., Sheng Q.H., Wu D.Q., Li L., Zeng R.
    Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA8MQ02_HUMAN
AccessioniPrimary (citable) accession number: A8MQ02
Entry historyi
Integrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: October 29, 2014
Last modified: May 11, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.