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Protein
Submitted name:

Afadin

Gene

AFDN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
AfadinImported
Gene namesi
Name:AFDNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000130396.20
HGNCiHGNC:7137 AFDN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130396

PTM / Processingi

Proteomic databases

EPDiA8MQ02
PeptideAtlasiA8MQ02
PRIDEiA8MQ02

Expressioni

Gene expression databases

BgeeiENSG00000130396
ExpressionAtlasiA8MQ02 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA8MQ02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92Ras-associatingInterPro annotationAdd BLAST92
Domaini205 – 307Ras-associatingInterPro annotationAdd BLAST103
Domaini627 – 867DiluteInterPro annotationAdd BLAST241
Domaini966 – 1052PDZInterPro annotationAdd BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili106 – 142Sequence analysisAdd BLAST37
Coiled coili1371 – 1402Sequence analysisAdd BLAST32
Coiled coili1485 – 1505Sequence analysisAdd BLAST21
Coiled coili1553 – 1620Sequence analysisAdd BLAST68

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1892 Eukaryota
ENOG410XR0S LUCA
GeneTreeiENSGT00390000010033
HOGENOMiHOG000008041
HOVERGENiHBG050463
KOiK05702

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15471 Myo5p-like_CBD_afadin, 1 hit
InterProiView protein in InterPro
IPR028842 Afadin
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10398 PTHR10398, 1 hit
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00498 FHA, 1 hit
PF00595 PDZ, 1 hit
PF00788 RA, 2 hits
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00240 FHA, 1 hit
SM00228 PDZ, 1 hit
SM00314 RA, 2 hits
SUPFAMiSSF49879 SSF49879, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50106 PDZ, 1 hit
PS50200 RA, 2 hits

Sequencei

Sequence statusi: Complete.

A8MQ02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFYFQDKAA GNFATKCIRV SSTATTQDVI ETLAEKFRPD MRMLSSPKYS
60 70 80 90 100
LYEVHVSGEE RRLDIDEKPL VVQLNWNKDD REGRFVLKNE NDAIPPKKAQ
110 120 130 140 150
SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS DKDDRPFQGE
160 170 180 190 200
DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD
210 220 230 240 250
GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN
260 270 280 290 300
PKDYCIARVM LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF
310 320 330 340 350
QLKRRPPDHI PKKTKKHLEG KTPKGKERAD GSGYGSTLPP EKLPYLVELS
360 370 380 390 400
PGRRNHFAYY NYHTYEDGSD SRDKPKLYRL QLSVTEVGTE KLDDNSIQLF
410 420 430 440 450
GPGIQPHHCD LTNMDGVVTV TPRSMDAETY VEGQRISETT MLQSGMKVQF
460 470 480 490 500
GASHVFKFVD PSQDHALAKR SVDGGLMVKG PRHKPGIVQE TTFDLGGDIH
510 520 530 540 550
SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ PDYRRQESRT
560 570 580 590 600
QDASGPELIL PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA
610 620 630 640 650
CRYVLSNQYR PDISPTERTH KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW
660 670 680 690 700
MANASELLNF IKQDRDLSRI TLDAQDVLAH LVQMAFKYLV HCLQSELNNY
710 720 730 740 750
MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA LTIQLFSQLF
760 770 780 790 800
HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE KQGLELAADC
810 820 830 840 850
HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL LQNYHCAPDE
860 870 880 890 900
PFIPTDLIEN VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS
910 920 930 940 950
CDVVRNIPNG LQEFLDPLCQ RGFCRLIPHT RSPGTWTIYF EGADYESHLL
960 970 980 990 1000
RENTELAQPL RKEPEIITVT LKKQNGMGLS IVAAKGAGQD KLGIYVKSVV
1010 1020 1030 1040 1050
KGGAADVDGR LAAGDQLLSV DGRSLVGLSQ ERAAELMTRT SSVVTLEVAK
1060 1070 1080 1090 1100
QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK PRPKSEGFEL YNNSTQNGSP
1110 1120 1130 1140 1150
ESPQLPWAEY SEPKKLPGDD RLMKNRADHR SSPNVANQPP SPGGKSAYAS
1160 1170 1180 1190 1200
GTTAKITSVS TGNLCTEEQT PPPRPEAYPI PTQTYTREYF TFPASKSQDR
1210 1220 1230 1240 1250
MAPPQNQWPN YEEKPHMHTD SNHSSIAIQR VTRSQEELRE DKAYQLERHR
1260 1270 1280 1290 1300
IEAAMDRKSD SDMWINQSSS LDSSTSSQEH LNHSSKSVTP ASTLTKSGPG
1310 1320 1330 1340 1350
RWKTPAAIPA TPVAVSQPIR TDLPPPPPPP PVHYAGDFDG MSMDLPLPPP
1360 1370 1380 1390 1400
PSANQIGLPS AQVAAAERRK REEHQRWYEK EKARLEEERE RKRREQERKL
1410 1420 1430 1440 1450
GQMRTQSLNP APFSPLTAQQ MKPEKPSTLQ RPQETVIREL QPQQQPRTIE
1460 1470 1480 1490 1500
RRDLQYITVS KEELSSGDSL SPDPWKRDAK EKLEKQQQMH IVDMLSKEIQ
1510 1520 1530 1540 1550
ELQSKPDRSA EESDRLRKLM LEWQFQKRLQ ESKQKDEDDE EEEDDDVDTM
1560 1570 1580 1590 1600
LIMQRLEAER RARDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK
1610 1620 1630 1640 1650
RDAEEKRRQE EGYYSRLEAE RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE
1660 1670 1680 1690 1700
PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD SLFTAKFVAY NEEEEEEDCS
1710 1720 1730 1740 1750
LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS GAPENLTFKE
1760 1770 1780
RQRLFSQGQD VSNKVKASRK LTELENELNT K
Length:1,781
Mass (Da):201,806
Last modified:October 29, 2014 - v2
Checksum:iF68F525A0822AD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009178 Genomic DNA No translation available.
AL049698 Genomic DNA No translation available.
AL731868 Genomic DNA No translation available.
KF458344 Genomic DNA No translation available.
RefSeqiNP_001278893.1, NM_001291964.1
UniGeneiHs.614974
Hs.728849
Hs.741785

Genome annotation databases

EnsembliENST00000366806; ENSP00000355771; ENSG00000130396
GeneIDi4301
KEGGihsa:4301
UCSCiuc021zik.2 human

Similar proteinsi

Entry informationi

Entry nameiA8MQ02_HUMAN
AccessioniPrimary (citable) accession number: A8MQ02
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: October 29, 2014
Last modified: April 25, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health